Markers for Ongoing or Previous Hepatitis E Virus Infection Are as Common in Wild Ungulates as in Humans in Sweden
Hepatitis E virus (HEV) is a human pathogen with zoonotic spread, infecting both domestic and wild animals. About 17% of the Swedish population is immune to HEV, but few cases are reported annually, indicating that most infections are subclinical. However, clinical hepatitis E may also be overlooked...
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ftdoajarticles:oai:doaj.org/article:c4ab72885382469399ecd8db064b1cb2 2023-05-15T13:13:29+02:00 Markers for Ongoing or Previous Hepatitis E Virus Infection Are as Common in Wild Ungulates as in Humans in Sweden Anette Roth Jay Lin Lars Magnius Marie Karlsson Sándór Belák Frederik Widén Heléne Norder 2016-09-01T00:00:00Z https://doi.org/10.3390/v8090259 https://doaj.org/article/c4ab72885382469399ecd8db064b1cb2 EN eng MDPI AG http://www.mdpi.com/1999-4915/8/9/259 https://doaj.org/toc/1999-4915 1999-4915 doi:10.3390/v8090259 https://doaj.org/article/c4ab72885382469399ecd8db064b1cb2 Viruses, Vol 8, Iss 9, p 259 (2016) hepatitis E virus zoonosis moose wild boar deer phylogenetic analysis wild animals Sweden Microbiology QR1-502 article 2016 ftdoajarticles https://doi.org/10.3390/v8090259 2022-12-31T00:32:52Z Hepatitis E virus (HEV) is a human pathogen with zoonotic spread, infecting both domestic and wild animals. About 17% of the Swedish population is immune to HEV, but few cases are reported annually, indicating that most infections are subclinical. However, clinical hepatitis E may also be overlooked. For identified cases, the source of infection is mostly unknown. In order to identify whether HEV may be spread from wild game, the prevalence of markers for past and/or ongoing infection was investigated in sera and stool samples collected from 260 hunted Swedish wild ungulates. HEV markers were found in 43 (17%) of the animals. The most commonly infected animal was moose (Alces alces) with 19 out of 69 animals (28%) showing HEV markers, followed by wild boar (Sus scrofa) with 21 out of 139 animals (15%), roe deer (Capreolus capreolus) with 2 out of 30 animals, red deer (Cervus elaphus) with 1 out of 15 animals, and fallow deer (Dama dama) 0 out of 7 animals. Partial open reading frame 1 (ORF1) of the viral genomes from the animals were sequenced and compared with those from 14 endemic human cases. Phylogenetic analysis revealed that three humans were infected with HEV strains similar to those from wild boar. These results indicate that wild animals may be a source of transmission to humans and could be an unrecognized public health concern. Article in Journal/Newspaper Alces alces Directory of Open Access Journals: DOAJ Articles Viruses 8 9 259 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
hepatitis E virus zoonosis moose wild boar deer phylogenetic analysis wild animals Sweden Microbiology QR1-502 |
spellingShingle |
hepatitis E virus zoonosis moose wild boar deer phylogenetic analysis wild animals Sweden Microbiology QR1-502 Anette Roth Jay Lin Lars Magnius Marie Karlsson Sándór Belák Frederik Widén Heléne Norder Markers for Ongoing or Previous Hepatitis E Virus Infection Are as Common in Wild Ungulates as in Humans in Sweden |
topic_facet |
hepatitis E virus zoonosis moose wild boar deer phylogenetic analysis wild animals Sweden Microbiology QR1-502 |
description |
Hepatitis E virus (HEV) is a human pathogen with zoonotic spread, infecting both domestic and wild animals. About 17% of the Swedish population is immune to HEV, but few cases are reported annually, indicating that most infections are subclinical. However, clinical hepatitis E may also be overlooked. For identified cases, the source of infection is mostly unknown. In order to identify whether HEV may be spread from wild game, the prevalence of markers for past and/or ongoing infection was investigated in sera and stool samples collected from 260 hunted Swedish wild ungulates. HEV markers were found in 43 (17%) of the animals. The most commonly infected animal was moose (Alces alces) with 19 out of 69 animals (28%) showing HEV markers, followed by wild boar (Sus scrofa) with 21 out of 139 animals (15%), roe deer (Capreolus capreolus) with 2 out of 30 animals, red deer (Cervus elaphus) with 1 out of 15 animals, and fallow deer (Dama dama) 0 out of 7 animals. Partial open reading frame 1 (ORF1) of the viral genomes from the animals were sequenced and compared with those from 14 endemic human cases. Phylogenetic analysis revealed that three humans were infected with HEV strains similar to those from wild boar. These results indicate that wild animals may be a source of transmission to humans and could be an unrecognized public health concern. |
format |
Article in Journal/Newspaper |
author |
Anette Roth Jay Lin Lars Magnius Marie Karlsson Sándór Belák Frederik Widén Heléne Norder |
author_facet |
Anette Roth Jay Lin Lars Magnius Marie Karlsson Sándór Belák Frederik Widén Heléne Norder |
author_sort |
Anette Roth |
title |
Markers for Ongoing or Previous Hepatitis E Virus Infection Are as Common in Wild Ungulates as in Humans in Sweden |
title_short |
Markers for Ongoing or Previous Hepatitis E Virus Infection Are as Common in Wild Ungulates as in Humans in Sweden |
title_full |
Markers for Ongoing or Previous Hepatitis E Virus Infection Are as Common in Wild Ungulates as in Humans in Sweden |
title_fullStr |
Markers for Ongoing or Previous Hepatitis E Virus Infection Are as Common in Wild Ungulates as in Humans in Sweden |
title_full_unstemmed |
Markers for Ongoing or Previous Hepatitis E Virus Infection Are as Common in Wild Ungulates as in Humans in Sweden |
title_sort |
markers for ongoing or previous hepatitis e virus infection are as common in wild ungulates as in humans in sweden |
publisher |
MDPI AG |
publishDate |
2016 |
url |
https://doi.org/10.3390/v8090259 https://doaj.org/article/c4ab72885382469399ecd8db064b1cb2 |
genre |
Alces alces |
genre_facet |
Alces alces |
op_source |
Viruses, Vol 8, Iss 9, p 259 (2016) |
op_relation |
http://www.mdpi.com/1999-4915/8/9/259 https://doaj.org/toc/1999-4915 1999-4915 doi:10.3390/v8090259 https://doaj.org/article/c4ab72885382469399ecd8db064b1cb2 |
op_doi |
https://doi.org/10.3390/v8090259 |
container_title |
Viruses |
container_volume |
8 |
container_issue |
9 |
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259 |
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1766258683227930624 |