Recent advances on pathogenesis, diagnosis, prevention, immunological aspects, and vectors of dengue: A review
Dengue is a vector-borne disease caused by the dengue virus (DENV) of family Flaviviridae. Dengue fever is common in both developed and developing countries. Globally, approximately 400 million cases of dengue fever are reported annually, resulting in approximately 22000 fatalities. Dengue cases in...
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ftdoajarticles:oai:doaj.org/article:c473b21c116d428c82484a362a3c77f2 2024-09-15T18:11:08+00:00 Recent advances on pathogenesis, diagnosis, prevention, immunological aspects, and vectors of dengue: A review Mahesh Chandra Sahu Rakesh Kumar Samantaray Aditi Pal Sanghamitra Pati 2023-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.383687 https://doaj.org/article/c473b21c116d428c82484a362a3c77f2 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=8;spage=325;epage=338;aulast=Sahu https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.383687 https://doaj.org/article/c473b21c116d428c82484a362a3c77f2 Asian Pacific Journal of Tropical Biomedicine, Vol 13, Iss 8, Pp 325-338 (2023) dengue aedes mosquitoes insecticide ns1 immunoglobulin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2023 ftdoajarticles https://doi.org/10.4103/2221-1691.383687 2024-08-05T17:49:19Z Dengue is a vector-borne disease caused by the dengue virus (DENV) of family Flaviviridae. Dengue fever is common in both developed and developing countries. Globally, approximately 400 million cases of dengue fever are reported annually, resulting in approximately 22000 fatalities. Dengue cases in India have progressively increased in the last decade. In recent years, substantial progress has been made in understanding various aspects of dengue, including its pathogenesis, diagnosis, prevention strategies, immunological responses, and the role of vectors in its transmission. The transmission of a positive RNA virus occurs through Aedes mosquitoes, specifically Aedes aegypti and Aedes albopictus. This virus is associated with a wide spectrum of symptoms, ranging from mild undifferentiated fever to severe hemorrhagic fever and shock, posing a potential threat to human health. There are 4 types of antigenically distinct dengue serotypes (DENV-1 to DENV-4) and among them, DENV-2 is more lethal and extremely severe. To overcome the severity of dengue, Dengvaxia is administered to children 9 to 16 years old with evidence of previous dengue infection. The diagnosis of dengue is carried out by ELISA-based non-structural protein (NS1) and immunoglobulin tests. However, there are no specific biomarkers to identify severe disease progression. Climatic factors and temperature play an important role in complex interaction among host, vector, and virus to manifest the severity of dengue. There is a need for the refinement of climate-based disease forecasting models in India to effectively control the spread of dengue. The mosquito repellent should be used periodically to kill or repel the Aedes mosquito to prevent the spread of dengue in humans. Article in Journal/Newspaper Human health Directory of Open Access Journals: DOAJ Articles Asian Pacific Journal of Tropical Biomedicine 13 8 325 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
dengue aedes mosquitoes insecticide ns1 immunoglobulin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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dengue aedes mosquitoes insecticide ns1 immunoglobulin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Mahesh Chandra Sahu Rakesh Kumar Samantaray Aditi Pal Sanghamitra Pati Recent advances on pathogenesis, diagnosis, prevention, immunological aspects, and vectors of dengue: A review |
topic_facet |
dengue aedes mosquitoes insecticide ns1 immunoglobulin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Dengue is a vector-borne disease caused by the dengue virus (DENV) of family Flaviviridae. Dengue fever is common in both developed and developing countries. Globally, approximately 400 million cases of dengue fever are reported annually, resulting in approximately 22000 fatalities. Dengue cases in India have progressively increased in the last decade. In recent years, substantial progress has been made in understanding various aspects of dengue, including its pathogenesis, diagnosis, prevention strategies, immunological responses, and the role of vectors in its transmission. The transmission of a positive RNA virus occurs through Aedes mosquitoes, specifically Aedes aegypti and Aedes albopictus. This virus is associated with a wide spectrum of symptoms, ranging from mild undifferentiated fever to severe hemorrhagic fever and shock, posing a potential threat to human health. There are 4 types of antigenically distinct dengue serotypes (DENV-1 to DENV-4) and among them, DENV-2 is more lethal and extremely severe. To overcome the severity of dengue, Dengvaxia is administered to children 9 to 16 years old with evidence of previous dengue infection. The diagnosis of dengue is carried out by ELISA-based non-structural protein (NS1) and immunoglobulin tests. However, there are no specific biomarkers to identify severe disease progression. Climatic factors and temperature play an important role in complex interaction among host, vector, and virus to manifest the severity of dengue. There is a need for the refinement of climate-based disease forecasting models in India to effectively control the spread of dengue. The mosquito repellent should be used periodically to kill or repel the Aedes mosquito to prevent the spread of dengue in humans. |
format |
Article in Journal/Newspaper |
author |
Mahesh Chandra Sahu Rakesh Kumar Samantaray Aditi Pal Sanghamitra Pati |
author_facet |
Mahesh Chandra Sahu Rakesh Kumar Samantaray Aditi Pal Sanghamitra Pati |
author_sort |
Mahesh Chandra Sahu |
title |
Recent advances on pathogenesis, diagnosis, prevention, immunological aspects, and vectors of dengue: A review |
title_short |
Recent advances on pathogenesis, diagnosis, prevention, immunological aspects, and vectors of dengue: A review |
title_full |
Recent advances on pathogenesis, diagnosis, prevention, immunological aspects, and vectors of dengue: A review |
title_fullStr |
Recent advances on pathogenesis, diagnosis, prevention, immunological aspects, and vectors of dengue: A review |
title_full_unstemmed |
Recent advances on pathogenesis, diagnosis, prevention, immunological aspects, and vectors of dengue: A review |
title_sort |
recent advances on pathogenesis, diagnosis, prevention, immunological aspects, and vectors of dengue: a review |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2023 |
url |
https://doi.org/10.4103/2221-1691.383687 https://doaj.org/article/c473b21c116d428c82484a362a3c77f2 |
genre |
Human health |
genre_facet |
Human health |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 13, Iss 8, Pp 325-338 (2023) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=8;spage=325;epage=338;aulast=Sahu https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.383687 https://doaj.org/article/c473b21c116d428c82484a362a3c77f2 |
op_doi |
https://doi.org/10.4103/2221-1691.383687 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
13 |
container_issue |
8 |
container_start_page |
325 |
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1810448725545320448 |