Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation
Abstract Background Iron deficiency is the most widespread nutrient deficiency and an important cause of developmental impairment in children. However, some studies have indicated that iron deficiency can also protect against malaria, which is a leading cause of childhood morbidity and mortality in...
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ftdoajarticles:oai:doaj.org/article:c445d8c587374ee18f92d8baa5cfae9b 2023-05-15T15:10:27+02:00 Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation Filip C. Castberg Lasse Maretty Trine Staalsoe Casper Hempel Erik Clasen-Linde Lars Hviid Jørgen A. L. Kurtzhals 2018-01-01T00:00:00Z https://doi.org/10.1186/s12936-018-2186-8 https://doaj.org/article/c445d8c587374ee18f92d8baa5cfae9b EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2186-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2186-8 1475-2875 https://doaj.org/article/c445d8c587374ee18f92d8baa5cfae9b Malaria Journal, Vol 17, Iss 1, Pp 1-12 (2018) Plasmodium chabaudi AS A/J mice Iron deficiency Malaria Hepcidin FGF23 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2186-8 2022-12-30T22:09:26Z Abstract Background Iron deficiency is the most widespread nutrient deficiency and an important cause of developmental impairment in children. However, some studies have indicated that iron deficiency can also protect against malaria, which is a leading cause of childhood morbidity and mortality in large parts of the world. This has rendered interventions against iron deficiency in malaria-endemic areas controversial. Methods The effect of nutritional iron deficiency on the clinical outcome of Plasmodium chabaudi AS infection in A/J mice and the impact of intravenous iron supplementation with ferric carboxymaltose were studied before and after parasite infection. Plasma levels of the iron status markers hepcidin and fibroblast growth factor 23 were measured in animals surviving and succumbing to malaria, and accompanying tissue pathology in the liver and the spleen was assessed. Results Nutritional iron deficiency was associated with increased mortality from P. chabaudi malaria. This increased mortality could be partially offset by carefully timed, short-duration adjunctive iron supplementation. Moribund animals were characterized by low levels of hepcidin and high levels of fibroblast growth factor 23. All infected mice had extramedullary splenic haematopoiesis, and iron-supplemented mice had visually detectable intracellular iron stores. Conclusions Blood transfusions are the only currently available means to correct severe anaemia in children with malaria. The potential of carefully timed, short-duration adjunctive iron supplementation as a safe alternative should be considered. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 17 1 |
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English |
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Plasmodium chabaudi AS A/J mice Iron deficiency Malaria Hepcidin FGF23 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Plasmodium chabaudi AS A/J mice Iron deficiency Malaria Hepcidin FGF23 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Filip C. Castberg Lasse Maretty Trine Staalsoe Casper Hempel Erik Clasen-Linde Lars Hviid Jørgen A. L. Kurtzhals Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation |
topic_facet |
Plasmodium chabaudi AS A/J mice Iron deficiency Malaria Hepcidin FGF23 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Iron deficiency is the most widespread nutrient deficiency and an important cause of developmental impairment in children. However, some studies have indicated that iron deficiency can also protect against malaria, which is a leading cause of childhood morbidity and mortality in large parts of the world. This has rendered interventions against iron deficiency in malaria-endemic areas controversial. Methods The effect of nutritional iron deficiency on the clinical outcome of Plasmodium chabaudi AS infection in A/J mice and the impact of intravenous iron supplementation with ferric carboxymaltose were studied before and after parasite infection. Plasma levels of the iron status markers hepcidin and fibroblast growth factor 23 were measured in animals surviving and succumbing to malaria, and accompanying tissue pathology in the liver and the spleen was assessed. Results Nutritional iron deficiency was associated with increased mortality from P. chabaudi malaria. This increased mortality could be partially offset by carefully timed, short-duration adjunctive iron supplementation. Moribund animals were characterized by low levels of hepcidin and high levels of fibroblast growth factor 23. All infected mice had extramedullary splenic haematopoiesis, and iron-supplemented mice had visually detectable intracellular iron stores. Conclusions Blood transfusions are the only currently available means to correct severe anaemia in children with malaria. The potential of carefully timed, short-duration adjunctive iron supplementation as a safe alternative should be considered. |
format |
Article in Journal/Newspaper |
author |
Filip C. Castberg Lasse Maretty Trine Staalsoe Casper Hempel Erik Clasen-Linde Lars Hviid Jørgen A. L. Kurtzhals |
author_facet |
Filip C. Castberg Lasse Maretty Trine Staalsoe Casper Hempel Erik Clasen-Linde Lars Hviid Jørgen A. L. Kurtzhals |
author_sort |
Filip C. Castberg |
title |
Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation |
title_short |
Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation |
title_full |
Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation |
title_fullStr |
Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation |
title_full_unstemmed |
Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation |
title_sort |
increased plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12936-018-2186-8 https://doaj.org/article/c445d8c587374ee18f92d8baa5cfae9b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 17, Iss 1, Pp 1-12 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12936-018-2186-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2186-8 1475-2875 https://doaj.org/article/c445d8c587374ee18f92d8baa5cfae9b |
op_doi |
https://doi.org/10.1186/s12936-018-2186-8 |
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Malaria Journal |
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17 |
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1 |
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1766341485702152192 |