T cell-dependent immunodepression in vivo in Schistosoma mansoni infected patients

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Maria Imaculada Muniz-Junqueira, Carlos Eduardo Tosta, Aluizio Prata
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1990
• Subjects: Esquistossomose; Imunodepressão celular; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/S0037-86821990000100005; https://doaj.org/article/c3c2d09619f24d56bab5f9197013e181

T-cell function was evaluated in 29 patients with either hepatointestinal or hepatosplenic schistosomiasis by intradermal tests to recall antigens. Immunodepression was detected in 26% of the subjects with hepatointestinal schistosomiasis and in 50% of those with the hepatosplenic form. Cellular immunodepression was related to worm load and spleen size. This non specific T-cell immunodepression may represent a serious constraint to the elimination of intracellular pathogens both in hepatosplenic or hepatointestinal schistosomiasis.