An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia.
Background Chikungunya virus (CHIKV) is an important emerging and re-emerging public health problem worldwide. In Indonesia, where the virus is endemic, epidemiological information from outside of the main islands of Java and Bali is limited. Methodology/principal findings Four hundred and seventy n...
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ftdoajarticles:oai:doaj.org/article:c37e1840147049ab8863ce5d7623aa06 2023-05-15T15:10:11+02:00 An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia. Samuel C B Stubbs Edison Johar Frilasita A Yudhaputri Benediktus Yohan Marsha S Santoso Rahma F Hayati Dionisius Denis Barbara A Blacklaws Ann M Powers R Tedjo Sasmono Khin Saw Aye Myint Simon D W Frost 2020-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008934 https://doaj.org/article/c37e1840147049ab8863ce5d7623aa06 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008934 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008934 https://doaj.org/article/c37e1840147049ab8863ce5d7623aa06 PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008934 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008934 2022-12-31T02:01:13Z Background Chikungunya virus (CHIKV) is an important emerging and re-emerging public health problem worldwide. In Indonesia, where the virus is endemic, epidemiological information from outside of the main islands of Java and Bali is limited. Methodology/principal findings Four hundred and seventy nine acutely febrile patients presenting between September 2017-2019 were recruited from three city hospitals situated in Ambon, Maluku; Banjarmasin, Kalimantan; and Batam, Batam Island as part of a multi-site observational study. CHIKV RNA was detected in a single serum sample while a separate sample was IgM positive. IgG seroprevalence was also low across all three sites, ranging from 1.4-3.2%. The single RT-PCR positive sample from this study and 24 archived samples collected during other recent outbreaks throughout Indonesia were subjected to complete coding region sequencing to assess the genetic diversity of Indonesian strains. Phylogenetic analysis revealed all to be of a single clade, which was distinct from CHIKV strains recently reported from neighbouring regions including the Philippines and the Pacific Islands. Conclusions/significance Chikungunya virus strains from recent outbreaks across Indonesia all belong to a single clade. However, low-level seroprevalence and molecular detection of CHIKV across the three study sites appears to contrast with the generally high seroprevalences that have been reported for non-outbreak settings in Java and Bali, and may account for the relative lack of CHIKV epidemiological data from other regions of Indonesia. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Pacific Bali ENVELOPE(-20.233,-20.233,64.067,64.067) PLOS Neglected Tropical Diseases 14 12 e0008934 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Samuel C B Stubbs Edison Johar Frilasita A Yudhaputri Benediktus Yohan Marsha S Santoso Rahma F Hayati Dionisius Denis Barbara A Blacklaws Ann M Powers R Tedjo Sasmono Khin Saw Aye Myint Simon D W Frost An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Chikungunya virus (CHIKV) is an important emerging and re-emerging public health problem worldwide. In Indonesia, where the virus is endemic, epidemiological information from outside of the main islands of Java and Bali is limited. Methodology/principal findings Four hundred and seventy nine acutely febrile patients presenting between September 2017-2019 were recruited from three city hospitals situated in Ambon, Maluku; Banjarmasin, Kalimantan; and Batam, Batam Island as part of a multi-site observational study. CHIKV RNA was detected in a single serum sample while a separate sample was IgM positive. IgG seroprevalence was also low across all three sites, ranging from 1.4-3.2%. The single RT-PCR positive sample from this study and 24 archived samples collected during other recent outbreaks throughout Indonesia were subjected to complete coding region sequencing to assess the genetic diversity of Indonesian strains. Phylogenetic analysis revealed all to be of a single clade, which was distinct from CHIKV strains recently reported from neighbouring regions including the Philippines and the Pacific Islands. Conclusions/significance Chikungunya virus strains from recent outbreaks across Indonesia all belong to a single clade. However, low-level seroprevalence and molecular detection of CHIKV across the three study sites appears to contrast with the generally high seroprevalences that have been reported for non-outbreak settings in Java and Bali, and may account for the relative lack of CHIKV epidemiological data from other regions of Indonesia. |
format |
Article in Journal/Newspaper |
author |
Samuel C B Stubbs Edison Johar Frilasita A Yudhaputri Benediktus Yohan Marsha S Santoso Rahma F Hayati Dionisius Denis Barbara A Blacklaws Ann M Powers R Tedjo Sasmono Khin Saw Aye Myint Simon D W Frost |
author_facet |
Samuel C B Stubbs Edison Johar Frilasita A Yudhaputri Benediktus Yohan Marsha S Santoso Rahma F Hayati Dionisius Denis Barbara A Blacklaws Ann M Powers R Tedjo Sasmono Khin Saw Aye Myint Simon D W Frost |
author_sort |
Samuel C B Stubbs |
title |
An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia. |
title_short |
An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia. |
title_full |
An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia. |
title_fullStr |
An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia. |
title_full_unstemmed |
An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia. |
title_sort |
investig-ation into the epidemiology of chikungunya virus across neglected regions of indonesia. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008934 https://doaj.org/article/c37e1840147049ab8863ce5d7623aa06 |
long_lat |
ENVELOPE(-20.233,-20.233,64.067,64.067) |
geographic |
Arctic Pacific Bali |
geographic_facet |
Arctic Pacific Bali |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008934 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008934 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008934 https://doaj.org/article/c37e1840147049ab8863ce5d7623aa06 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008934 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
12 |
container_start_page |
e0008934 |
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1766341228170838016 |