Development and validation of a severity scale for leprosy type 1 reactions.
OBJECTIVES: To develop a valid and reliable quantitative measure of leprosy Type 1 reactions. METHODS: A scale was developed from previous scales which had not been validated. The face and content validity were assessed following consultation with recognised experts in the field. The construct valid...
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ftdoajarticles:oai:doaj.org/article:c2c06ee9f3224a49839bdb140a8608a6 2023-05-15T15:09:56+02:00 Development and validation of a severity scale for leprosy type 1 reactions. Stephen L Walker Peter G Nicholls C Ruth Butlin Jose Augusto C Nery Hemanto K Roy Emanuel Rangel Anna M Sales Diana N J Lockwood 2008-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000351 https://doaj.org/article/c2c06ee9f3224a49839bdb140a8608a6 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2596969?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000351 https://doaj.org/article/c2c06ee9f3224a49839bdb140a8608a6 PLoS Neglected Tropical Diseases, Vol 2, Iss 12, p e351 (2008) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2008 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000351 2022-12-31T13:01:19Z OBJECTIVES: To develop a valid and reliable quantitative measure of leprosy Type 1 reactions. METHODS: A scale was developed from previous scales which had not been validated. The face and content validity were assessed following consultation with recognised experts in the field. The construct validity was determined by applying the scale to patients in Bangladesh and Brazil who had been diagnosed with leprosy Type 1 reaction. An expert categorized each patient's reaction as mild or moderate or severe. Another worker applied the scale. This was done independently. In a subsequent stage of the study the agreement between two observers was assessed. RESULTS: The scale had good internal consistency demonstrated by a Cronbach's alpha >0.8. Removal of three items from the original scale resulted in better discrimination between disease severity categories. Cut off points for Type 1 reaction severities were determined using Receiver Operating Characteristic curves. A mild Type 1 reaction is characterized using the final scale by a score of 4 or less. A moderate reaction is a score of between 4.5 and 8.5. A severe reaction is a score of 9 or more. CONCLUSIONS: We have developed a valid and reliable tool for quantifying leprosy Type 1 reaction severity and believe this will be a useful tool in research of this condition, in observational and intervention studies, and in the comparison of clinical and laboratory parameters. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 2 12 e351 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Stephen L Walker Peter G Nicholls C Ruth Butlin Jose Augusto C Nery Hemanto K Roy Emanuel Rangel Anna M Sales Diana N J Lockwood Development and validation of a severity scale for leprosy type 1 reactions. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVES: To develop a valid and reliable quantitative measure of leprosy Type 1 reactions. METHODS: A scale was developed from previous scales which had not been validated. The face and content validity were assessed following consultation with recognised experts in the field. The construct validity was determined by applying the scale to patients in Bangladesh and Brazil who had been diagnosed with leprosy Type 1 reaction. An expert categorized each patient's reaction as mild or moderate or severe. Another worker applied the scale. This was done independently. In a subsequent stage of the study the agreement between two observers was assessed. RESULTS: The scale had good internal consistency demonstrated by a Cronbach's alpha >0.8. Removal of three items from the original scale resulted in better discrimination between disease severity categories. Cut off points for Type 1 reaction severities were determined using Receiver Operating Characteristic curves. A mild Type 1 reaction is characterized using the final scale by a score of 4 or less. A moderate reaction is a score of between 4.5 and 8.5. A severe reaction is a score of 9 or more. CONCLUSIONS: We have developed a valid and reliable tool for quantifying leprosy Type 1 reaction severity and believe this will be a useful tool in research of this condition, in observational and intervention studies, and in the comparison of clinical and laboratory parameters. |
format |
Article in Journal/Newspaper |
author |
Stephen L Walker Peter G Nicholls C Ruth Butlin Jose Augusto C Nery Hemanto K Roy Emanuel Rangel Anna M Sales Diana N J Lockwood |
author_facet |
Stephen L Walker Peter G Nicholls C Ruth Butlin Jose Augusto C Nery Hemanto K Roy Emanuel Rangel Anna M Sales Diana N J Lockwood |
author_sort |
Stephen L Walker |
title |
Development and validation of a severity scale for leprosy type 1 reactions. |
title_short |
Development and validation of a severity scale for leprosy type 1 reactions. |
title_full |
Development and validation of a severity scale for leprosy type 1 reactions. |
title_fullStr |
Development and validation of a severity scale for leprosy type 1 reactions. |
title_full_unstemmed |
Development and validation of a severity scale for leprosy type 1 reactions. |
title_sort |
development and validation of a severity scale for leprosy type 1 reactions. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2008 |
url |
https://doi.org/10.1371/journal.pntd.0000351 https://doaj.org/article/c2c06ee9f3224a49839bdb140a8608a6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 2, Iss 12, p e351 (2008) |
op_relation |
http://europepmc.org/articles/PMC2596969?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000351 https://doaj.org/article/c2c06ee9f3224a49839bdb140a8608a6 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000351 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
2 |
container_issue |
12 |
container_start_page |
e351 |
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1766341029277990912 |