Pharmacological aspects of fisetin

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Lucia Dwi Antika, Rita Marleta Dewi
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2021
• Subjects: fisetin; anti-inflammatory; anti-diabetic; anti-carcinogenic; anti-osteoporosis; cardioprotective activity; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic; Human health
• Online Access: https://doi.org/10.4103/2221-1691.300726; https://doaj.org/article/c2934b9efa25457dbdc7e521650ca136

Over the past decades, epidemiological studies have concluded that a diet rich in plant-derived products plays a pivotal role in human health. Fisetin (3,3’,4’,7-tetrahydroxyflavone) is a hydrophobic polyphenolic compound primarily found in edible plants (e.g. strawberry, blueberry, apple, grape, persimmon, kiwi, and cucumber). Various preclinical studies have revealed that fisetin exhibits a wide range of pharmacological effects such as antioxidant, anti-inflammatory, anti-carcinogenic, anti-osteoporotic, antimicrobial, and anti-diabetic properties. Therefore, the pharmacological in vitro and in vivo studies on fisetin are discussed in this review. Additionally, this review would be useful for further study regarding the potential of natural products, notably fisetin, and its therapeutic potential for the prevention and treatment of diseases.