In vitro antifungal susceptibility of Candida speciesisolated from diabetic patients

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Mohammad Taghi Hedayati, Mahin Tavakoli, Fateme Zakavi, Tahereh Shokohi, Ramin Mofarrah, Saham Ansari, Mojtaba Taghizadeh Armaki
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: Diabetes; Candida; Antifungal susceptibility test; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0332-2017; https://doaj.org/article/c28ce75f3b514213a336ab54d16c1e14

Abstract INTRODUCTION This study aims to evaluate the antifungal susceptibility of different species of Candida isolated from diabetic patients against eight antifungal agents. METHODS Susceptibility testing of 111 clinical isolates of Candida species was performed against 8 antifungals using the M27-A3 protocol of the Clinical and Laboratory Standards Institute (CLSI). RESULTS Voriconazole, lanoconazole, and caspofungin showed the highest in vitro activity against all the isolates of C. albicans. Resistance against the tested antifungals was only observed in the C. albicans isolates. CONCLUSIONS Our finding revealed that resistance against amphotericin B, itraconazole, ketoconazole, posaconazole, and fluconazole can be observed in C. albicans.