Evaluation of intrathecal synthesis of specific IgG antibodies against Toxoplasma gondii in the diagnosis assessment of presumptive toxoplasma encephalitis in aids patients Avaliação da síntese intratecal de anticorpos IgG anti-Toxoplasma gondii para o diagnóstico da neurotoxoplasmose em pacientes com síndrome da imunodeficiência adquirida
The diagnosis of neurotoxoplasmosis in patients with acquired immunodeficiency syndrome is mainly based on tomographic or magnetic resonance findings and on the response to specific treatment. We studied 55 patients with AIDS and neurotoxoplasmosis according to these diagnostic criteria (group 1), 3...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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ftdoajarticles:oai:doaj.org/article:c276a0e68c1441a1b4784cb6888aed82 2023-05-15T15:17:47+02:00 Evaluation of intrathecal synthesis of specific IgG antibodies against Toxoplasma gondii in the diagnosis assessment of presumptive toxoplasma encephalitis in aids patients Avaliação da síntese intratecal de anticorpos IgG anti-Toxoplasma gondii para o diagnóstico da neurotoxoplasmose em pacientes com síndrome da imunodeficiência adquirida Aercio Sebastião Borges José Fernando de Castro Figueiredo 2004-12-01T00:00:00Z https://doi.org/10.1590/S0037-86822004000600010 https://doaj.org/article/c276a0e68c1441a1b4784cb6888aed82 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822004000600010 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 doi:10.1590/S0037-86822004000600010 0037-8682 1678-9849 https://doaj.org/article/c276a0e68c1441a1b4784cb6888aed82 Revista da Sociedade Brasileira de Medicina Tropical, Vol 37, Iss 6, Pp 480-484 (2004) SIDA Neurotoxoplasmose Síntese de anticorpos Sistema Nerevoso Central AIDS Neurotoxoplasmosis Antibody synthesis Central nervous system Arctic medicine. Tropical medicine RC955-962 article 2004 ftdoajarticles https://doi.org/10.1590/S0037-86822004000600010 2022-12-31T02:54:48Z The diagnosis of neurotoxoplasmosis in patients with acquired immunodeficiency syndrome is mainly based on tomographic or magnetic resonance findings and on the response to specific treatment. We studied 55 patients with AIDS and neurotoxoplasmosis according to these diagnostic criteria (group 1), 37 patients with AIDS and neurological involvement of other etiology (group 2), and 16 anti-HIV-negative individuals with neurological manifestations (group 3). Serum and cerebrospinal fluid were examined for the presence of anti-T. gondii IgG, by indirect immunofluorescence. In 72 of them, the total amounts of these antibodies were determined in order to assess local production of anti-T. gondii antibodies in the central nervous system and to correlate their titers with infection activity in patients with AIDS and neurotoxoplasmosis. IgG titers > 1/64 in cerebrospinal fluid reached 100% specificity for the diagnosis of neurotoxoplasmosis in AIDS. Evidence of local synthesis of these antibodies was detected in 42.8% of patients of group 1, in 29.1% of patients of group 2 and in no patient of group 3. The test showed 70.8% specificity and therefore was not useful in our study for the differential diagnosis of neurotoxoplasmosis in patients with AIDS. O diagnóstico da neurotoxoplasmose em pacientes com síndrome da imunodeficiência adquirida baseia-se fundamentalmente nos achados tomográficos ou de ressonância magnética e na resposta ao tratamento específico. Estudamos 55 pacientes com SIDA e neurotoxoplasmose, de acordo com estes critérios diagnósticos (grupo 1); 37 pacientes com SIDA e comprometimento neurológico por outra etiologia (grupo 2) e 16 indivíduos anti-HIV negativo, com outras doenças neurológicas (grupo 3), pesquisando IgG, anti-T. gondii, no soro e no líquor, utilizando a reação de imunofluorescência indireta. Em 72 casos, determinamos os teores totais destes anticorpos aí presentes, com objetivo de avaliar a produção local, no sistema nervoso central, de anticorpos específicos e correlacionar os títulos ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Sida ENVELOPE(101.683,101.683,67.800,67.800) Revista da Sociedade Brasileira de Medicina Tropical 37 6 480 484 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
SIDA Neurotoxoplasmose Síntese de anticorpos Sistema Nerevoso Central AIDS Neurotoxoplasmosis Antibody synthesis Central nervous system Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
SIDA Neurotoxoplasmose Síntese de anticorpos Sistema Nerevoso Central AIDS Neurotoxoplasmosis Antibody synthesis Central nervous system Arctic medicine. Tropical medicine RC955-962 Aercio Sebastião Borges José Fernando de Castro Figueiredo Evaluation of intrathecal synthesis of specific IgG antibodies against Toxoplasma gondii in the diagnosis assessment of presumptive toxoplasma encephalitis in aids patients Avaliação da síntese intratecal de anticorpos IgG anti-Toxoplasma gondii para o diagnóstico da neurotoxoplasmose em pacientes com síndrome da imunodeficiência adquirida |
topic_facet |
SIDA Neurotoxoplasmose Síntese de anticorpos Sistema Nerevoso Central AIDS Neurotoxoplasmosis Antibody synthesis Central nervous system Arctic medicine. Tropical medicine RC955-962 |
description |
The diagnosis of neurotoxoplasmosis in patients with acquired immunodeficiency syndrome is mainly based on tomographic or magnetic resonance findings and on the response to specific treatment. We studied 55 patients with AIDS and neurotoxoplasmosis according to these diagnostic criteria (group 1), 37 patients with AIDS and neurological involvement of other etiology (group 2), and 16 anti-HIV-negative individuals with neurological manifestations (group 3). Serum and cerebrospinal fluid were examined for the presence of anti-T. gondii IgG, by indirect immunofluorescence. In 72 of them, the total amounts of these antibodies were determined in order to assess local production of anti-T. gondii antibodies in the central nervous system and to correlate their titers with infection activity in patients with AIDS and neurotoxoplasmosis. IgG titers > 1/64 in cerebrospinal fluid reached 100% specificity for the diagnosis of neurotoxoplasmosis in AIDS. Evidence of local synthesis of these antibodies was detected in 42.8% of patients of group 1, in 29.1% of patients of group 2 and in no patient of group 3. The test showed 70.8% specificity and therefore was not useful in our study for the differential diagnosis of neurotoxoplasmosis in patients with AIDS. O diagnóstico da neurotoxoplasmose em pacientes com síndrome da imunodeficiência adquirida baseia-se fundamentalmente nos achados tomográficos ou de ressonância magnética e na resposta ao tratamento específico. Estudamos 55 pacientes com SIDA e neurotoxoplasmose, de acordo com estes critérios diagnósticos (grupo 1); 37 pacientes com SIDA e comprometimento neurológico por outra etiologia (grupo 2) e 16 indivíduos anti-HIV negativo, com outras doenças neurológicas (grupo 3), pesquisando IgG, anti-T. gondii, no soro e no líquor, utilizando a reação de imunofluorescência indireta. Em 72 casos, determinamos os teores totais destes anticorpos aí presentes, com objetivo de avaliar a produção local, no sistema nervoso central, de anticorpos específicos e correlacionar os títulos ... |
format |
Article in Journal/Newspaper |
author |
Aercio Sebastião Borges José Fernando de Castro Figueiredo |
author_facet |
Aercio Sebastião Borges José Fernando de Castro Figueiredo |
author_sort |
Aercio Sebastião Borges |
title |
Evaluation of intrathecal synthesis of specific IgG antibodies against Toxoplasma gondii in the diagnosis assessment of presumptive toxoplasma encephalitis in aids patients Avaliação da síntese intratecal de anticorpos IgG anti-Toxoplasma gondii para o diagnóstico da neurotoxoplasmose em pacientes com síndrome da imunodeficiência adquirida |
title_short |
Evaluation of intrathecal synthesis of specific IgG antibodies against Toxoplasma gondii in the diagnosis assessment of presumptive toxoplasma encephalitis in aids patients Avaliação da síntese intratecal de anticorpos IgG anti-Toxoplasma gondii para o diagnóstico da neurotoxoplasmose em pacientes com síndrome da imunodeficiência adquirida |
title_full |
Evaluation of intrathecal synthesis of specific IgG antibodies against Toxoplasma gondii in the diagnosis assessment of presumptive toxoplasma encephalitis in aids patients Avaliação da síntese intratecal de anticorpos IgG anti-Toxoplasma gondii para o diagnóstico da neurotoxoplasmose em pacientes com síndrome da imunodeficiência adquirida |
title_fullStr |
Evaluation of intrathecal synthesis of specific IgG antibodies against Toxoplasma gondii in the diagnosis assessment of presumptive toxoplasma encephalitis in aids patients Avaliação da síntese intratecal de anticorpos IgG anti-Toxoplasma gondii para o diagnóstico da neurotoxoplasmose em pacientes com síndrome da imunodeficiência adquirida |
title_full_unstemmed |
Evaluation of intrathecal synthesis of specific IgG antibodies against Toxoplasma gondii in the diagnosis assessment of presumptive toxoplasma encephalitis in aids patients Avaliação da síntese intratecal de anticorpos IgG anti-Toxoplasma gondii para o diagnóstico da neurotoxoplasmose em pacientes com síndrome da imunodeficiência adquirida |
title_sort |
evaluation of intrathecal synthesis of specific igg antibodies against toxoplasma gondii in the diagnosis assessment of presumptive toxoplasma encephalitis in aids patients avaliação da síntese intratecal de anticorpos igg anti-toxoplasma gondii para o diagnóstico da neurotoxoplasmose em pacientes com síndrome da imunodeficiência adquirida |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2004 |
url |
https://doi.org/10.1590/S0037-86822004000600010 https://doaj.org/article/c276a0e68c1441a1b4784cb6888aed82 |
long_lat |
ENVELOPE(101.683,101.683,67.800,67.800) |
geographic |
Arctic Sida |
geographic_facet |
Arctic Sida |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 37, Iss 6, Pp 480-484 (2004) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822004000600010 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 doi:10.1590/S0037-86822004000600010 0037-8682 1678-9849 https://doaj.org/article/c276a0e68c1441a1b4784cb6888aed82 |
op_doi |
https://doi.org/10.1590/S0037-86822004000600010 |
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37 |
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