Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966.
Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth me...
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ftdoajarticles:oai:doaj.org/article:c2630e1f5eed4a23851d703bb73ddc2c 2023-05-15T17:42:32+02:00 Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966. Jessica L Buxton Shikta Das Alina Rodriguez Marika Kaakinen Alexessander Couto Alves Sylvain Sebert Iona Y Millwood Jaana Laitinen Paul F O'Reilly Marjo-Riitta Jarvelin Alexandra I F Blakemore 2014-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0099133 https://doaj.org/article/c2630e1f5eed4a23851d703bb73ddc2c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4053385?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0099133 https://doaj.org/article/c2630e1f5eed4a23851d703bb73ddc2c PLoS ONE, Vol 9, Iss 6, p e99133 (2014) Medicine R Science Q article 2014 ftdoajarticles https://doi.org/10.1371/journal.pone.0099133 2022-12-30T22:51:46Z Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth measures (BMI and age at adiposity rebound (AR)); ii) change in BMI from childhood to adulthood and iii) adult BMI, waist-to-hip ratio (WHR), body adiposity index (BAI). Childhood BMI at AR was positively associated with LTL at 31 years in women (P = 0.041). Adult BMI and WHR in both men (P = 0.025 and P = 0.049, respectively) and women (P = 0.029 and P = 0.008, respectively), and BAI in women (P = 0.021) were inversely associated with LTL at 31 years. An increase in standardised BMI between early childhood and adulthood was associated with shorter adult LTL in women (P = 0.008). We show that LTL is inversely associated with multiple measures of adiposity in both men and women. Additionally, BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31, potentially indicating accelerated biological ageing. Article in Journal/Newspaper Northern Finland Directory of Open Access Journals: DOAJ Articles PLoS ONE 9 6 e99133 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Jessica L Buxton Shikta Das Alina Rodriguez Marika Kaakinen Alexessander Couto Alves Sylvain Sebert Iona Y Millwood Jaana Laitinen Paul F O'Reilly Marjo-Riitta Jarvelin Alexandra I F Blakemore Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966. |
topic_facet |
Medicine R Science Q |
description |
Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth measures (BMI and age at adiposity rebound (AR)); ii) change in BMI from childhood to adulthood and iii) adult BMI, waist-to-hip ratio (WHR), body adiposity index (BAI). Childhood BMI at AR was positively associated with LTL at 31 years in women (P = 0.041). Adult BMI and WHR in both men (P = 0.025 and P = 0.049, respectively) and women (P = 0.029 and P = 0.008, respectively), and BAI in women (P = 0.021) were inversely associated with LTL at 31 years. An increase in standardised BMI between early childhood and adulthood was associated with shorter adult LTL in women (P = 0.008). We show that LTL is inversely associated with multiple measures of adiposity in both men and women. Additionally, BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31, potentially indicating accelerated biological ageing. |
format |
Article in Journal/Newspaper |
author |
Jessica L Buxton Shikta Das Alina Rodriguez Marika Kaakinen Alexessander Couto Alves Sylvain Sebert Iona Y Millwood Jaana Laitinen Paul F O'Reilly Marjo-Riitta Jarvelin Alexandra I F Blakemore |
author_facet |
Jessica L Buxton Shikta Das Alina Rodriguez Marika Kaakinen Alexessander Couto Alves Sylvain Sebert Iona Y Millwood Jaana Laitinen Paul F O'Reilly Marjo-Riitta Jarvelin Alexandra I F Blakemore |
author_sort |
Jessica L Buxton |
title |
Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966. |
title_short |
Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966. |
title_full |
Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966. |
title_fullStr |
Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966. |
title_full_unstemmed |
Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966. |
title_sort |
multiple measures of adiposity are associated with mean leukocyte telomere length in the northern finland birth cohort 1966. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pone.0099133 https://doaj.org/article/c2630e1f5eed4a23851d703bb73ddc2c |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
PLoS ONE, Vol 9, Iss 6, p e99133 (2014) |
op_relation |
http://europepmc.org/articles/PMC4053385?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0099133 https://doaj.org/article/c2630e1f5eed4a23851d703bb73ddc2c |
op_doi |
https://doi.org/10.1371/journal.pone.0099133 |
container_title |
PLoS ONE |
container_volume |
9 |
container_issue |
6 |
container_start_page |
e99133 |
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1766144418954346496 |