Determinants of HIV-malaria co-infection among people living with HIV on anti-retroviral therapy in Northeast Ethiopia: unmatched case control study
Abstract Background HIV and malaria are the leading causes of morbidity and mortality in the developing world including Ethiopia. Globally, HIV-malaria co-infection causes approximately 3 million deaths per year. However, both these infections are preventable if measures are taken on determinant fac...
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ftdoajarticles:oai:doaj.org/article:c235484178ac4153879312bb606e0372 2023-05-15T15:16:43+02:00 Determinants of HIV-malaria co-infection among people living with HIV on anti-retroviral therapy in Northeast Ethiopia: unmatched case control study Tenaw Yibeltal Dereje Birhanu Abitew Amsalu Birara Melese Yared Mulu 2020-11-01T00:00:00Z https://doi.org/10.1186/s41182-020-00286-9 https://doaj.org/article/c235484178ac4153879312bb606e0372 EN eng BMC https://doi.org/10.1186/s41182-020-00286-9 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-020-00286-9 1349-4147 https://doaj.org/article/c235484178ac4153879312bb606e0372 Tropical Medicine and Health, Vol 48, Iss 1, Pp 1-8 (2020) Malaria HIV/AIDS Co-infections PLWHA Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.1186/s41182-020-00286-9 2022-12-31T07:45:37Z Abstract Background HIV and malaria are the leading causes of morbidity and mortality in the developing world including Ethiopia. Globally, HIV-malaria co-infection causes approximately 3 million deaths per year. However, both these infections are preventable if measures are taken on determinant factors. The objective of the study was therefore to assess factors associated with HIV-malaria co-infection among HIV-positive people who lived in Shewarobit district, northeast Ethiopia. Methods Unmatched case-control study was conducted among people living with HIV (PLWHA) in Shewarobit district from February 28, 2018, to April 30, 2018. The sample size was determined taking the assumption of 95% CI, 85% power, 3:1 control to case ratio, the proportion of PLWHA-malaria coinfection of 22.7%, OR 2.73, and 10% non-response rate. The final sample size was 262 (66 cases and 196 controls). Cases were adults on anti-retroviral therapy and diagnosed positive for malaria by microscopy while controls were adults on anti-retroviral therapy and diagnosed negative for malaria by microscopy in the previous 6 months before the survey. Result The median age of cases and controls in years was 35 (IQR = 19) and 38 (IQR = 19) respectively. Variables that had a significant association with HIV-malaria co-infection were non-in-door residual spraying (adjusted odds ratio (AOR) = 4.91; 95% CI 4.03, 15.13), poor perception on the health risk of HIV-malaria co-infections (AOR = 4.11; 95% CI 1.28, 10.17), non-use of insecticidal treated bed nets (AOR = 6.21; 95%CI 2.74, 14.11), non-use of cotrimoxazole prophylaxis (AOR = 2.42; 95% CI 1.11, 5.28), and not received health education on the risk of HIV-malaria interaction (AOR = 4.11; 95% CI 1.24, 4.84). Conclusion Provision of cotrimoxazole prophylaxis, sleeping under an insecticidal treated bed net, and indoor residual spraying help to reduce HIV-malaria co-infection-associated morbidity/mortality. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Tropical Medicine and Health 48 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Malaria HIV/AIDS Co-infections PLWHA Arctic medicine. Tropical medicine RC955-962 |
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Malaria HIV/AIDS Co-infections PLWHA Arctic medicine. Tropical medicine RC955-962 Tenaw Yibeltal Dereje Birhanu Abitew Amsalu Birara Melese Yared Mulu Determinants of HIV-malaria co-infection among people living with HIV on anti-retroviral therapy in Northeast Ethiopia: unmatched case control study |
topic_facet |
Malaria HIV/AIDS Co-infections PLWHA Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background HIV and malaria are the leading causes of morbidity and mortality in the developing world including Ethiopia. Globally, HIV-malaria co-infection causes approximately 3 million deaths per year. However, both these infections are preventable if measures are taken on determinant factors. The objective of the study was therefore to assess factors associated with HIV-malaria co-infection among HIV-positive people who lived in Shewarobit district, northeast Ethiopia. Methods Unmatched case-control study was conducted among people living with HIV (PLWHA) in Shewarobit district from February 28, 2018, to April 30, 2018. The sample size was determined taking the assumption of 95% CI, 85% power, 3:1 control to case ratio, the proportion of PLWHA-malaria coinfection of 22.7%, OR 2.73, and 10% non-response rate. The final sample size was 262 (66 cases and 196 controls). Cases were adults on anti-retroviral therapy and diagnosed positive for malaria by microscopy while controls were adults on anti-retroviral therapy and diagnosed negative for malaria by microscopy in the previous 6 months before the survey. Result The median age of cases and controls in years was 35 (IQR = 19) and 38 (IQR = 19) respectively. Variables that had a significant association with HIV-malaria co-infection were non-in-door residual spraying (adjusted odds ratio (AOR) = 4.91; 95% CI 4.03, 15.13), poor perception on the health risk of HIV-malaria co-infections (AOR = 4.11; 95% CI 1.28, 10.17), non-use of insecticidal treated bed nets (AOR = 6.21; 95%CI 2.74, 14.11), non-use of cotrimoxazole prophylaxis (AOR = 2.42; 95% CI 1.11, 5.28), and not received health education on the risk of HIV-malaria interaction (AOR = 4.11; 95% CI 1.24, 4.84). Conclusion Provision of cotrimoxazole prophylaxis, sleeping under an insecticidal treated bed net, and indoor residual spraying help to reduce HIV-malaria co-infection-associated morbidity/mortality. |
format |
Article in Journal/Newspaper |
author |
Tenaw Yibeltal Dereje Birhanu Abitew Amsalu Birara Melese Yared Mulu |
author_facet |
Tenaw Yibeltal Dereje Birhanu Abitew Amsalu Birara Melese Yared Mulu |
author_sort |
Tenaw Yibeltal |
title |
Determinants of HIV-malaria co-infection among people living with HIV on anti-retroviral therapy in Northeast Ethiopia: unmatched case control study |
title_short |
Determinants of HIV-malaria co-infection among people living with HIV on anti-retroviral therapy in Northeast Ethiopia: unmatched case control study |
title_full |
Determinants of HIV-malaria co-infection among people living with HIV on anti-retroviral therapy in Northeast Ethiopia: unmatched case control study |
title_fullStr |
Determinants of HIV-malaria co-infection among people living with HIV on anti-retroviral therapy in Northeast Ethiopia: unmatched case control study |
title_full_unstemmed |
Determinants of HIV-malaria co-infection among people living with HIV on anti-retroviral therapy in Northeast Ethiopia: unmatched case control study |
title_sort |
determinants of hiv-malaria co-infection among people living with hiv on anti-retroviral therapy in northeast ethiopia: unmatched case control study |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s41182-020-00286-9 https://doaj.org/article/c235484178ac4153879312bb606e0372 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 48, Iss 1, Pp 1-8 (2020) |
op_relation |
https://doi.org/10.1186/s41182-020-00286-9 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-020-00286-9 1349-4147 https://doaj.org/article/c235484178ac4153879312bb606e0372 |
op_doi |
https://doi.org/10.1186/s41182-020-00286-9 |
container_title |
Tropical Medicine and Health |
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48 |
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1 |
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1766347019356471296 |