Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice.
Several studies have demonstrated that Zika virus (ZIKV) damages testis and leads to infertility in mice; however, the infection in the epididymis, another important organ of male reproductive health, has gained less attention. Previously, we detected lesions in the epididymis in interferon type I a...
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ftdoajarticles:oai:doaj.org/article:c225df7971c94c6ab6d4fe4a9eb77eb3 2023-05-15T15:10:34+02:00 Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice. Ziyang Sheng Na Gao Dongying Fan Na Wu Yingying Zhang Daishu Han Yun Zhang Weilong Tan Peigang Wang Jing An 2021-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009211 https://doaj.org/article/c225df7971c94c6ab6d4fe4a9eb77eb3 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009211 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009211 https://doaj.org/article/c225df7971c94c6ab6d4fe4a9eb77eb3 PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009211 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009211 2022-12-31T15:20:35Z Several studies have demonstrated that Zika virus (ZIKV) damages testis and leads to infertility in mice; however, the infection in the epididymis, another important organ of male reproductive health, has gained less attention. Previously, we detected lesions in the epididymis in interferon type I and II receptor knockout male mice during ZIKV infection. Herein, the pathogenesis of ZIKV in the epididymis was further assessed in the infected mice after footpad inoculation. ZIKV efficiently replicated in the epididymis, and principal cells were susceptible to ZIKV. ZIKV infection disrupted the histomorphology of the epididymis, and the effects were characterized by a decrease in the thickness of the epithelial layer and an increase in the luminal diameter, especially at the proximal end. Significant inflammatory cell infiltration was observed in the epididymis accompanied by an increase in the levels of interleukin (IL)-6 and IL-28. The expression of tight junction proteins was downregulated and associated with disordered arrangement of the junctions. Importantly, the expression levels of aquaporin 1 and lipocalin 8, indicators of the absorption and secretion functions of the epididymis, were markedly reduced, and the proteins were redistributed. These events synergistically altered the microenvironment for sperm maturation, disturbed sperm transport downstream, and may impact male reproductive health. Overall, these results provide new insights into the pathogenesis of the male reproductive damage caused by ZIKV infection and the possible contribution of epididymal injury into this process. Therefore, male fertility of the population in areas of ZIKV epidemic requires additional attention. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 3 e0009211 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ziyang Sheng Na Gao Dongying Fan Na Wu Yingying Zhang Daishu Han Yun Zhang Weilong Tan Peigang Wang Jing An Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Several studies have demonstrated that Zika virus (ZIKV) damages testis and leads to infertility in mice; however, the infection in the epididymis, another important organ of male reproductive health, has gained less attention. Previously, we detected lesions in the epididymis in interferon type I and II receptor knockout male mice during ZIKV infection. Herein, the pathogenesis of ZIKV in the epididymis was further assessed in the infected mice after footpad inoculation. ZIKV efficiently replicated in the epididymis, and principal cells were susceptible to ZIKV. ZIKV infection disrupted the histomorphology of the epididymis, and the effects were characterized by a decrease in the thickness of the epithelial layer and an increase in the luminal diameter, especially at the proximal end. Significant inflammatory cell infiltration was observed in the epididymis accompanied by an increase in the levels of interleukin (IL)-6 and IL-28. The expression of tight junction proteins was downregulated and associated with disordered arrangement of the junctions. Importantly, the expression levels of aquaporin 1 and lipocalin 8, indicators of the absorption and secretion functions of the epididymis, were markedly reduced, and the proteins were redistributed. These events synergistically altered the microenvironment for sperm maturation, disturbed sperm transport downstream, and may impact male reproductive health. Overall, these results provide new insights into the pathogenesis of the male reproductive damage caused by ZIKV infection and the possible contribution of epididymal injury into this process. Therefore, male fertility of the population in areas of ZIKV epidemic requires additional attention. |
format |
Article in Journal/Newspaper |
author |
Ziyang Sheng Na Gao Dongying Fan Na Wu Yingying Zhang Daishu Han Yun Zhang Weilong Tan Peigang Wang Jing An |
author_facet |
Ziyang Sheng Na Gao Dongying Fan Na Wu Yingying Zhang Daishu Han Yun Zhang Weilong Tan Peigang Wang Jing An |
author_sort |
Ziyang Sheng |
title |
Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice. |
title_short |
Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice. |
title_full |
Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice. |
title_fullStr |
Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice. |
title_full_unstemmed |
Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice. |
title_sort |
zika virus disrupts the barrier structure and absorption/secretion functions of the epididymis in mice. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009211 https://doaj.org/article/c225df7971c94c6ab6d4fe4a9eb77eb3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009211 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009211 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009211 https://doaj.org/article/c225df7971c94c6ab6d4fe4a9eb77eb3 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009211 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
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3 |
container_start_page |
e0009211 |
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1766341571113910272 |