Different distributions of nerve demyelination in chronic acquired multifocal polyneuropathies
Abstract. Background. Multifocal motor neuropathy (MMN), Lewis-Sumner syndrome (LSS), and many chronic inflammatory demyelinating polyradiculoneuropathies (CIDPs) are representative of acquired multifocal polyneuropathy and are characterized by conduction block (CB). This retrospective study aimed t...
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Wolters Kluwer
2020
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Online Access: | https://doi.org/10.1097/CM9.0000000000001073 https://doaj.org/article/c2253f6a6f5d409e8eca49a6da1b1e9b |
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ftdoajarticles:oai:doaj.org/article:c2253f6a6f5d409e8eca49a6da1b1e9b 2023-05-15T16:01:44+02:00 Different distributions of nerve demyelination in chronic acquired multifocal polyneuropathies Xia-Jun Zhou Ying Zhu De-Sheng Zhu Lu Han Qian-Yun Liu Xiao-Niu Liang Yong Hao Ze-Zhi Li Yang-Tai Guan Yan-Jie Yin Xiu-Yuan Hao 2020-11-01T00:00:00Z https://doi.org/10.1097/CM9.0000000000001073 https://doaj.org/article/c2253f6a6f5d409e8eca49a6da1b1e9b EN eng Wolters Kluwer http://journals.lww.com/10.1097/CM9.0000000000001073 https://doaj.org/toc/0366-6999 https://doaj.org/toc/2542-5641 0366-6999 2542-5641 doi:10.1097/CM9.0000000000001073 https://doaj.org/article/c2253f6a6f5d409e8eca49a6da1b1e9b Chinese Medical Journal, Vol 133, Iss 21, Pp 2558-2564 (2020) Medicine R article 2020 ftdoajarticles https://doi.org/10.1097/CM9.0000000000001073 2022-12-31T05:59:16Z Abstract. Background. Multifocal motor neuropathy (MMN), Lewis-Sumner syndrome (LSS), and many chronic inflammatory demyelinating polyradiculoneuropathies (CIDPs) are representative of acquired multifocal polyneuropathy and are characterized by conduction block (CB). This retrospective study aimed to investigate the demyelinating distribution and the selective vulnerability of MMN, LSS, and CIDP with CB (CIDP-CB) in nerves. Methods. Fifteen LSS subjects (107 nerves), 24 MMN subjects (176 nerves), and 17 CIDP-CB subjects (110 nerves) were included. Their clinical information was recorded, blood and cerebrospinal fluid tests were conducted, and nerve conductions of the median, ulnar, radial, peroneal, and tibial nerves were evaluated. CB, temporal dispersion, distal motor latency (DML), and F-wave latency were recorded, and nerve conduction velocity, terminal latency index, and modified F-wave ratio were calculated. Results. CB was more likely to occur around the elbow in CIDP-CB than in MMN (78.6% vs. 6.8%, P < 0.01) but less likely to occur between the wrist and the elbow than in LSS (10.7% vs. 39.3%, P < 0.05). Tibial nerve CB was most frequently observed in MMN (47.4%, P < 0.05). CIDP-CB was characterized by a prolonged DML in all nerves, and slow motor nerve velocity of the upper limb was significant when CB nerves were excluded (P < 0.05). Conclusions. We report the different distributions of segmental and diffuse demyelination of the ulnar and tibial nerves in LSS, MMN, and CIDP-CB. These distinct distributions could help in differentiating among these conditions. Article in Journal/Newspaper DML Directory of Open Access Journals: DOAJ Articles Sumner ENVELOPE(-63.727,-63.727,-74.499,-74.499) Chinese Medical Journal 133 21 2558 2564 |
institution |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Medicine R |
spellingShingle |
Medicine R Xia-Jun Zhou Ying Zhu De-Sheng Zhu Lu Han Qian-Yun Liu Xiao-Niu Liang Yong Hao Ze-Zhi Li Yang-Tai Guan Yan-Jie Yin Xiu-Yuan Hao Different distributions of nerve demyelination in chronic acquired multifocal polyneuropathies |
topic_facet |
Medicine R |
description |
Abstract. Background. Multifocal motor neuropathy (MMN), Lewis-Sumner syndrome (LSS), and many chronic inflammatory demyelinating polyradiculoneuropathies (CIDPs) are representative of acquired multifocal polyneuropathy and are characterized by conduction block (CB). This retrospective study aimed to investigate the demyelinating distribution and the selective vulnerability of MMN, LSS, and CIDP with CB (CIDP-CB) in nerves. Methods. Fifteen LSS subjects (107 nerves), 24 MMN subjects (176 nerves), and 17 CIDP-CB subjects (110 nerves) were included. Their clinical information was recorded, blood and cerebrospinal fluid tests were conducted, and nerve conductions of the median, ulnar, radial, peroneal, and tibial nerves were evaluated. CB, temporal dispersion, distal motor latency (DML), and F-wave latency were recorded, and nerve conduction velocity, terminal latency index, and modified F-wave ratio were calculated. Results. CB was more likely to occur around the elbow in CIDP-CB than in MMN (78.6% vs. 6.8%, P < 0.01) but less likely to occur between the wrist and the elbow than in LSS (10.7% vs. 39.3%, P < 0.05). Tibial nerve CB was most frequently observed in MMN (47.4%, P < 0.05). CIDP-CB was characterized by a prolonged DML in all nerves, and slow motor nerve velocity of the upper limb was significant when CB nerves were excluded (P < 0.05). Conclusions. We report the different distributions of segmental and diffuse demyelination of the ulnar and tibial nerves in LSS, MMN, and CIDP-CB. These distinct distributions could help in differentiating among these conditions. |
format |
Article in Journal/Newspaper |
author |
Xia-Jun Zhou Ying Zhu De-Sheng Zhu Lu Han Qian-Yun Liu Xiao-Niu Liang Yong Hao Ze-Zhi Li Yang-Tai Guan Yan-Jie Yin Xiu-Yuan Hao |
author_facet |
Xia-Jun Zhou Ying Zhu De-Sheng Zhu Lu Han Qian-Yun Liu Xiao-Niu Liang Yong Hao Ze-Zhi Li Yang-Tai Guan Yan-Jie Yin Xiu-Yuan Hao |
author_sort |
Xia-Jun Zhou |
title |
Different distributions of nerve demyelination in chronic acquired multifocal polyneuropathies |
title_short |
Different distributions of nerve demyelination in chronic acquired multifocal polyneuropathies |
title_full |
Different distributions of nerve demyelination in chronic acquired multifocal polyneuropathies |
title_fullStr |
Different distributions of nerve demyelination in chronic acquired multifocal polyneuropathies |
title_full_unstemmed |
Different distributions of nerve demyelination in chronic acquired multifocal polyneuropathies |
title_sort |
different distributions of nerve demyelination in chronic acquired multifocal polyneuropathies |
publisher |
Wolters Kluwer |
publishDate |
2020 |
url |
https://doi.org/10.1097/CM9.0000000000001073 https://doaj.org/article/c2253f6a6f5d409e8eca49a6da1b1e9b |
long_lat |
ENVELOPE(-63.727,-63.727,-74.499,-74.499) |
geographic |
Sumner |
geographic_facet |
Sumner |
genre |
DML |
genre_facet |
DML |
op_source |
Chinese Medical Journal, Vol 133, Iss 21, Pp 2558-2564 (2020) |
op_relation |
http://journals.lww.com/10.1097/CM9.0000000000001073 https://doaj.org/toc/0366-6999 https://doaj.org/toc/2542-5641 0366-6999 2542-5641 doi:10.1097/CM9.0000000000001073 https://doaj.org/article/c2253f6a6f5d409e8eca49a6da1b1e9b |
op_doi |
https://doi.org/10.1097/CM9.0000000000001073 |
container_title |
Chinese Medical Journal |
container_volume |
133 |
container_issue |
21 |
container_start_page |
2558 |
op_container_end_page |
2564 |
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1766397477850710016 |