Risk Factors for Bartonella species Infection in Blood Donors from Southeast Brazil.
Bacteria from the genus Bartonella are emerging blood-borne bacteria, capable of causing long-lasting infection in marine and terrestrial mammals, including humans. Bartonella are generally well adapted to their main host, causing persistent infection without clinical manifestation. However, these o...
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ftdoajarticles:oai:doaj.org/article:c223fd2c85154d60af154cf7340eec5d 2023-05-15T15:12:01+02:00 Risk Factors for Bartonella species Infection in Blood Donors from Southeast Brazil. Pedro Paulo Vissotto de Paiva Diniz Paulo Eduardo Neves Ferreira Velho Luiza Helena Urso Pitassi Marina Rovani Drummond Bruno Grosselli Lania Maria Lourdes Barjas-Castro Stanley Sowy Edward B Breitschwerdt Diana Gerardi Scorpio 2016-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004509 https://doaj.org/article/c223fd2c85154d60af154cf7340eec5d EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4801220?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004509 https://doaj.org/article/c223fd2c85154d60af154cf7340eec5d PLoS Neglected Tropical Diseases, Vol 10, Iss 3, p e0004509 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004509 2022-12-31T05:31:13Z Bacteria from the genus Bartonella are emerging blood-borne bacteria, capable of causing long-lasting infection in marine and terrestrial mammals, including humans. Bartonella are generally well adapted to their main host, causing persistent infection without clinical manifestation. However, these organisms may cause severe disease in natural or accidental hosts. In humans, Bartonella species have been detected from sick patients presented with diverse disease manifestations, including cat scratch disease, trench fever, bacillary angiomatosis, endocarditis, polyarthritis, or granulomatous inflammatory disease. However, with the advances in diagnostic methods, subclinical bloodstream infection in humans has been reported, with the potential for transmission through blood transfusion been recently investigated by our group. The objective of this study was to determine the risk factors associated with Bartonella species infection in asymptomatic blood donors presented at a major blood bank in Southeastern Brazil. Five hundred blood donors were randomly enrolled and tested for Bartonella species infection by specialized blood cultured coupled with high-sensitive PCR assays. Epidemiological questionnaires were designed to cover major potential risk factors, such as age, gender, ethnicity, contact with companion animals, livestock, or wild animals, bites from insects or animal, economical status, among other factors. Based on multivariate logistic regression, bloodstream infection with B. henselae or B. clarridgeiae was associated with cat contact (adjusted OR: 3.4, 95% CI: 1.1-9.6) or history of tick bite (adjusted OR: 3.7, 95% CI: 1.3-13.4). These risk factors should be considered during donor screening, as bacteremia by these Bartonella species may not be detected by traditional laboratory screening methods, and it may be transmitted by blood transfusion. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 3 e0004509 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Pedro Paulo Vissotto de Paiva Diniz Paulo Eduardo Neves Ferreira Velho Luiza Helena Urso Pitassi Marina Rovani Drummond Bruno Grosselli Lania Maria Lourdes Barjas-Castro Stanley Sowy Edward B Breitschwerdt Diana Gerardi Scorpio Risk Factors for Bartonella species Infection in Blood Donors from Southeast Brazil. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Bacteria from the genus Bartonella are emerging blood-borne bacteria, capable of causing long-lasting infection in marine and terrestrial mammals, including humans. Bartonella are generally well adapted to their main host, causing persistent infection without clinical manifestation. However, these organisms may cause severe disease in natural or accidental hosts. In humans, Bartonella species have been detected from sick patients presented with diverse disease manifestations, including cat scratch disease, trench fever, bacillary angiomatosis, endocarditis, polyarthritis, or granulomatous inflammatory disease. However, with the advances in diagnostic methods, subclinical bloodstream infection in humans has been reported, with the potential for transmission through blood transfusion been recently investigated by our group. The objective of this study was to determine the risk factors associated with Bartonella species infection in asymptomatic blood donors presented at a major blood bank in Southeastern Brazil. Five hundred blood donors were randomly enrolled and tested for Bartonella species infection by specialized blood cultured coupled with high-sensitive PCR assays. Epidemiological questionnaires were designed to cover major potential risk factors, such as age, gender, ethnicity, contact with companion animals, livestock, or wild animals, bites from insects or animal, economical status, among other factors. Based on multivariate logistic regression, bloodstream infection with B. henselae or B. clarridgeiae was associated with cat contact (adjusted OR: 3.4, 95% CI: 1.1-9.6) or history of tick bite (adjusted OR: 3.7, 95% CI: 1.3-13.4). These risk factors should be considered during donor screening, as bacteremia by these Bartonella species may not be detected by traditional laboratory screening methods, and it may be transmitted by blood transfusion. |
format |
Article in Journal/Newspaper |
author |
Pedro Paulo Vissotto de Paiva Diniz Paulo Eduardo Neves Ferreira Velho Luiza Helena Urso Pitassi Marina Rovani Drummond Bruno Grosselli Lania Maria Lourdes Barjas-Castro Stanley Sowy Edward B Breitschwerdt Diana Gerardi Scorpio |
author_facet |
Pedro Paulo Vissotto de Paiva Diniz Paulo Eduardo Neves Ferreira Velho Luiza Helena Urso Pitassi Marina Rovani Drummond Bruno Grosselli Lania Maria Lourdes Barjas-Castro Stanley Sowy Edward B Breitschwerdt Diana Gerardi Scorpio |
author_sort |
Pedro Paulo Vissotto de Paiva Diniz |
title |
Risk Factors for Bartonella species Infection in Blood Donors from Southeast Brazil. |
title_short |
Risk Factors for Bartonella species Infection in Blood Donors from Southeast Brazil. |
title_full |
Risk Factors for Bartonella species Infection in Blood Donors from Southeast Brazil. |
title_fullStr |
Risk Factors for Bartonella species Infection in Blood Donors from Southeast Brazil. |
title_full_unstemmed |
Risk Factors for Bartonella species Infection in Blood Donors from Southeast Brazil. |
title_sort |
risk factors for bartonella species infection in blood donors from southeast brazil. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004509 https://doaj.org/article/c223fd2c85154d60af154cf7340eec5d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 3, p e0004509 (2016) |
op_relation |
http://europepmc.org/articles/PMC4801220?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004509 https://doaj.org/article/c223fd2c85154d60af154cf7340eec5d |
op_doi |
https://doi.org/10.1371/journal.pntd.0004509 |
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PLOS Neglected Tropical Diseases |
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3 |
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e0004509 |
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