Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females
Abstract Background Obesity has emerged as a public health crisis in many populations including Egypt. Adipose tissue produces a number of adipokines, one of them is adiponectin which has attracted much attention because of its antidiabetic and antiatherogenic effects. Objective To determine the eff...
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ftdoajarticles:oai:doaj.org/article:c21c20ac3f2e4316a3b084fc6403ac5e 2023-05-15T15:13:17+02:00 Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females Walaa H. Foula Rana H. Emara Mona K. Eldeeb Samiha A. Mokhtar Fikrat A. El-Sahn 2020-12-01T00:00:00Z https://doi.org/10.1186/s42506-020-00060-z https://doaj.org/article/c21c20ac3f2e4316a3b084fc6403ac5e EN eng SpringerOpen https://doi.org/10.1186/s42506-020-00060-z https://doaj.org/toc/2090-262X doi:10.1186/s42506-020-00060-z 2090-262X https://doaj.org/article/c21c20ac3f2e4316a3b084fc6403ac5e Journal of the Egyptian Public Health Association, Vol 95, Iss 1, Pp 1-8 (2020) Adipokines Adiponectin Insulin resistance Weight reduction Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1186/s42506-020-00060-z 2022-12-31T06:07:41Z Abstract Background Obesity has emerged as a public health crisis in many populations including Egypt. Adipose tissue produces a number of adipokines, one of them is adiponectin which has attracted much attention because of its antidiabetic and antiatherogenic effects. Objective To determine the effect of a weight loss program on serum adiponectin level and insulin resistance among overweight and obese adult premenopausal females. Study design A pre-postintervention study was carried out among 95 premenopausal overweight and obese females (body mass index ≥ 25 kg/m2) aged 20 to 40 years at the integrated health clinic affiliated to the High Institute of Public Health, Alexandria, Egypt, from February 2016 to February 2017. All participants underwent a weight loss program based on a reduced calorie balanced diet and advised to increase their physical activity. Dietary instructions and follow-up were done weekly throughout 16 weeks. Blood samples were collected to investigate serum adiponectin level and insulin resistance at the beginning and the end of the intervention. Results After 16 weeks, a significant decrease in body weight by 9.7% was associated with a significant increase in serum adiponectin from 13.3 ± 4.9 μg/ml to 18.5 ± 5.6 μg/ml. Both fasting insulin and insulin resistance had decreased significantly by 13.6% and 13.7%, respectively. Conclusion A weight reduction program depending on a reduced calorie diet for 16 weeks was associated with a significant increase in total adiponectin level and reduction in insulin resistance. An emphasis on the importance of keeping normal weight through nutritional education and the promotion of healthy diets is recommended to reduce the risk of occurrence of insulin resistance, type 2 diabetes, and cardiovascular diseases. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of the Egyptian Public Health Association 95 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Adipokines Adiponectin Insulin resistance Weight reduction Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Adipokines Adiponectin Insulin resistance Weight reduction Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Walaa H. Foula Rana H. Emara Mona K. Eldeeb Samiha A. Mokhtar Fikrat A. El-Sahn Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females |
topic_facet |
Adipokines Adiponectin Insulin resistance Weight reduction Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Abstract Background Obesity has emerged as a public health crisis in many populations including Egypt. Adipose tissue produces a number of adipokines, one of them is adiponectin which has attracted much attention because of its antidiabetic and antiatherogenic effects. Objective To determine the effect of a weight loss program on serum adiponectin level and insulin resistance among overweight and obese adult premenopausal females. Study design A pre-postintervention study was carried out among 95 premenopausal overweight and obese females (body mass index ≥ 25 kg/m2) aged 20 to 40 years at the integrated health clinic affiliated to the High Institute of Public Health, Alexandria, Egypt, from February 2016 to February 2017. All participants underwent a weight loss program based on a reduced calorie balanced diet and advised to increase their physical activity. Dietary instructions and follow-up were done weekly throughout 16 weeks. Blood samples were collected to investigate serum adiponectin level and insulin resistance at the beginning and the end of the intervention. Results After 16 weeks, a significant decrease in body weight by 9.7% was associated with a significant increase in serum adiponectin from 13.3 ± 4.9 μg/ml to 18.5 ± 5.6 μg/ml. Both fasting insulin and insulin resistance had decreased significantly by 13.6% and 13.7%, respectively. Conclusion A weight reduction program depending on a reduced calorie diet for 16 weeks was associated with a significant increase in total adiponectin level and reduction in insulin resistance. An emphasis on the importance of keeping normal weight through nutritional education and the promotion of healthy diets is recommended to reduce the risk of occurrence of insulin resistance, type 2 diabetes, and cardiovascular diseases. |
format |
Article in Journal/Newspaper |
author |
Walaa H. Foula Rana H. Emara Mona K. Eldeeb Samiha A. Mokhtar Fikrat A. El-Sahn |
author_facet |
Walaa H. Foula Rana H. Emara Mona K. Eldeeb Samiha A. Mokhtar Fikrat A. El-Sahn |
author_sort |
Walaa H. Foula |
title |
Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females |
title_short |
Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females |
title_full |
Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females |
title_fullStr |
Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females |
title_full_unstemmed |
Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females |
title_sort |
effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females |
publisher |
SpringerOpen |
publishDate |
2020 |
url |
https://doi.org/10.1186/s42506-020-00060-z https://doaj.org/article/c21c20ac3f2e4316a3b084fc6403ac5e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of the Egyptian Public Health Association, Vol 95, Iss 1, Pp 1-8 (2020) |
op_relation |
https://doi.org/10.1186/s42506-020-00060-z https://doaj.org/toc/2090-262X doi:10.1186/s42506-020-00060-z 2090-262X https://doaj.org/article/c21c20ac3f2e4316a3b084fc6403ac5e |
op_doi |
https://doi.org/10.1186/s42506-020-00060-z |
container_title |
Journal of the Egyptian Public Health Association |
container_volume |
95 |
container_issue |
1 |
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1766343853412974592 |