An exceptional case report of disseminated cryptococcosis in a hitherto immunocompetent patient
ABSTRACT Cryptococcosis is an opportunistic fungal infection causes significant disease predominantly in immunocompromised patients. Here we present an excepcional case of disseminated cryptococcosis with pulmonary and cerebral involvement in an immunocompetent patient with no apparent predisposing...
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ftdoajarticles:oai:doaj.org/article:c20c3a70fe2e49cc9eb5483949129411 2024-09-09T19:27:21+00:00 An exceptional case report of disseminated cryptococcosis in a hitherto immunocompetent patient Tatjana Adzic-Vukicevic Muge Cevik Jasmina Poluga Jelena Micic Salvatore Rubino Bianca Paglietti Aleksandra Barac 2020-01-01T00:00:00Z https://doi.org/10.1590/s1678-9946202062003 https://doaj.org/article/c20c3a70fe2e49cc9eb5483949129411 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652020000100502&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946202062003 https://doaj.org/article/c20c3a70fe2e49cc9eb5483949129411 Revista do Instituto de Medicina Tropical de São Paulo, Vol 62 (2020) Cryptococcus Disseminated infection Malignancy Prostatic adenocarcinoma Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1590/s1678-9946202062003 2024-08-05T17:49:30Z ABSTRACT Cryptococcosis is an opportunistic fungal infection causes significant disease predominantly in immunocompromised patients. Here we present an excepcional case of disseminated cryptococcosis with pulmonary and cerebral involvement in an immunocompetent patient with no apparent predisposing factors at the time of hospital admission. We described a case of an apparently immunocompetent 66-years old man admitted to hospital with a one-month history of cough, fever and vertigo. During hospitalization, thorax imaging was suggestive of lung metastasis, therefore, he went through several investigations. During hospitalization, he developed neurological symptoms and subsequently underwent a lumbar puncture. Cerebrospinal fluid (CSF) culture was positive for Cryptococcus spp. isolated on Sabouraud’s dextrose agar and bird seed agar. In addition, the direct microscopy examination was positive for the India ink test, as well as with the latex agglutination test for cryptococcal polysaccharide antigen (CrAg) in CSF, while serum CrAg was negative. Despite the absence of classic immunocompromising features, he was treated with amphotericin B and fluconazole due to suspected disseminated cryptococcal infection. Later, he was diagnosed with prostatic adenocarcinoma. Upon successful completion of treatment for disseminated cryptococcosis, the patient underwent radical prostate ablation surgery as a treatment forprostatic adenocarcinoma. This exceptional case emphasizes the high degree of suspicion of atypical infections, and in these cases, it is particularly important to consider fungal infections in hitherto healthy patients with no apparent predisposing factors. Although Cryptococcus spp. is predominantly reported in patients with hematological malignancies, cryptococcosis investigation should also be considered as part of the initial workup of patients with a new diagnosis of a solid tumour prior to chemotherapy or radiotherapy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 62 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Cryptococcus Disseminated infection Malignancy Prostatic adenocarcinoma Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Cryptococcus Disseminated infection Malignancy Prostatic adenocarcinoma Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Tatjana Adzic-Vukicevic Muge Cevik Jasmina Poluga Jelena Micic Salvatore Rubino Bianca Paglietti Aleksandra Barac An exceptional case report of disseminated cryptococcosis in a hitherto immunocompetent patient |
topic_facet |
Cryptococcus Disseminated infection Malignancy Prostatic adenocarcinoma Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
ABSTRACT Cryptococcosis is an opportunistic fungal infection causes significant disease predominantly in immunocompromised patients. Here we present an excepcional case of disseminated cryptococcosis with pulmonary and cerebral involvement in an immunocompetent patient with no apparent predisposing factors at the time of hospital admission. We described a case of an apparently immunocompetent 66-years old man admitted to hospital with a one-month history of cough, fever and vertigo. During hospitalization, thorax imaging was suggestive of lung metastasis, therefore, he went through several investigations. During hospitalization, he developed neurological symptoms and subsequently underwent a lumbar puncture. Cerebrospinal fluid (CSF) culture was positive for Cryptococcus spp. isolated on Sabouraud’s dextrose agar and bird seed agar. In addition, the direct microscopy examination was positive for the India ink test, as well as with the latex agglutination test for cryptococcal polysaccharide antigen (CrAg) in CSF, while serum CrAg was negative. Despite the absence of classic immunocompromising features, he was treated with amphotericin B and fluconazole due to suspected disseminated cryptococcal infection. Later, he was diagnosed with prostatic adenocarcinoma. Upon successful completion of treatment for disseminated cryptococcosis, the patient underwent radical prostate ablation surgery as a treatment forprostatic adenocarcinoma. This exceptional case emphasizes the high degree of suspicion of atypical infections, and in these cases, it is particularly important to consider fungal infections in hitherto healthy patients with no apparent predisposing factors. Although Cryptococcus spp. is predominantly reported in patients with hematological malignancies, cryptococcosis investigation should also be considered as part of the initial workup of patients with a new diagnosis of a solid tumour prior to chemotherapy or radiotherapy. |
format |
Article in Journal/Newspaper |
author |
Tatjana Adzic-Vukicevic Muge Cevik Jasmina Poluga Jelena Micic Salvatore Rubino Bianca Paglietti Aleksandra Barac |
author_facet |
Tatjana Adzic-Vukicevic Muge Cevik Jasmina Poluga Jelena Micic Salvatore Rubino Bianca Paglietti Aleksandra Barac |
author_sort |
Tatjana Adzic-Vukicevic |
title |
An exceptional case report of disseminated cryptococcosis in a hitherto immunocompetent patient |
title_short |
An exceptional case report of disseminated cryptococcosis in a hitherto immunocompetent patient |
title_full |
An exceptional case report of disseminated cryptococcosis in a hitherto immunocompetent patient |
title_fullStr |
An exceptional case report of disseminated cryptococcosis in a hitherto immunocompetent patient |
title_full_unstemmed |
An exceptional case report of disseminated cryptococcosis in a hitherto immunocompetent patient |
title_sort |
exceptional case report of disseminated cryptococcosis in a hitherto immunocompetent patient |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2020 |
url |
https://doi.org/10.1590/s1678-9946202062003 https://doaj.org/article/c20c3a70fe2e49cc9eb5483949129411 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 62 (2020) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652020000100502&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946202062003 https://doaj.org/article/c20c3a70fe2e49cc9eb5483949129411 |
op_doi |
https://doi.org/10.1590/s1678-9946202062003 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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62 |
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