Helminth species-specific effects on IFN-γ producing T cells during active and latent tuberculosis.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Amare Kiflie, Gezahegn Bewket, Fitsumbrhan Tajebe, Ebba Abate, Thomas Schӧn, Robert Blomgran
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2023
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Rif
• Online Access: https://doi.org/10.1371/journal.pntd.0011094; https://doaj.org/article/c1b1a6e2e9e44ccdb87408b5140e042a

Background Interferon-γ (IFN-γ) is a key cytokine inducing protective immune responses during tuberculosis (TB) infection. Helminth-induced immune responses may affect IFN-γ production by T cells, although its connection with disease severity and immune recovery during treatment is unexplored. We in...