Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil
Abstract INTRODUCTION: Malnutrition and kala-azar (or visceral leishmaniasis) are significant public health problems in different parts of the world. Immunity and susceptibility to infectious and parasitic diseases are directly linked to the host’s nutritional state, but little is known about the in...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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Online Access: | https://doi.org/10.1590/0037-8682-0800-2020 https://doaj.org/article/c1a24d7485574e9f9b75b98c55423413 |
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ftdoajarticles:oai:doaj.org/article:c1a24d7485574e9f9b75b98c55423413 2023-05-15T15:11:04+02:00 Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil Mísia Joyner de Sousa Dias Monteiro Maria Nauside Pessoa da Silva Adriana de Azevedo Paiva Dilina do Nascimento Marreiro Liania Alves Luzia Gilberto Simeone Henriques Patrícia Helen de Carvalho Rondó Ingridi de Souza Sene Ana Tárcila Alves de Almeida Carlos Henrique Nery Costa Dorcas Lamounier Costa 2021-09-01T00:00:00Z https://doi.org/10.1590/0037-8682-0800-2020 https://doaj.org/article/c1a24d7485574e9f9b75b98c55423413 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100335&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0800-2020 https://doaj.org/article/c1a24d7485574e9f9b75b98c55423413 Revista da Sociedade Brasileira de Medicina Tropical, Vol 54 (2021) Leishmaniasis Visceral Kala-azar Malnutrition Vitamin A Zinc Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.1590/0037-8682-0800-2020 2022-12-30T23:24:25Z Abstract INTRODUCTION: Malnutrition and kala-azar (or visceral leishmaniasis) are significant public health problems in different parts of the world. Immunity and susceptibility to infectious and parasitic diseases are directly linked to the host’s nutritional state, but little is known about the interaction between nutrition and kala-azar. This study aimed to evaluate nutritional status with kala-azar and correlate these findings with the clinical and laboratory manifestations of the disease, and zinc and retinol levels. METHODS: This was a cross-sectional study of 139 patients with kala-azar. Nutritional status classification was performed according to international recommendations. Parametric or nonparametric tests were applied whenever indicated in a two-sided test with a 5% significance level. RESULTS: Weight loss and malnutrition were more frequent in adults. Body mass index-for-age, fat area of the arm, and upper arm muscle area were significantly associated with probability of death. The presence of human immunodeficiency virus, hepatomegaly, and splenomegaly was correlated with nutritional assessment. Blood leukocyte and lymphocyte, serum creatine, and vitamin A levels were significantly higher in adult men. Vitamin A levels were highly associated with the level of hemoglobin and C-reactive protein (CRP) in multivariate analysis. All patients had reduced plasma zinc levels, but this finding had no association with the outcome variables. CONCLUSIONS: Malnutrition was correlated with severe disease and was more prevalent in older people with kala-azar. Vitamin A deficiency was associated with hemoglobin and CRP. Zinc levels were reduced in patients with kala-azar. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Azar ENVELOPE(-63.733,-63.733,-64.983,-64.983) Revista da Sociedade Brasileira de Medicina Tropical 54 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Leishmaniasis Visceral Kala-azar Malnutrition Vitamin A Zinc Arctic medicine. Tropical medicine RC955-962 |
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Leishmaniasis Visceral Kala-azar Malnutrition Vitamin A Zinc Arctic medicine. Tropical medicine RC955-962 Mísia Joyner de Sousa Dias Monteiro Maria Nauside Pessoa da Silva Adriana de Azevedo Paiva Dilina do Nascimento Marreiro Liania Alves Luzia Gilberto Simeone Henriques Patrícia Helen de Carvalho Rondó Ingridi de Souza Sene Ana Tárcila Alves de Almeida Carlos Henrique Nery Costa Dorcas Lamounier Costa Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil |
topic_facet |
Leishmaniasis Visceral Kala-azar Malnutrition Vitamin A Zinc Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: Malnutrition and kala-azar (or visceral leishmaniasis) are significant public health problems in different parts of the world. Immunity and susceptibility to infectious and parasitic diseases are directly linked to the host’s nutritional state, but little is known about the interaction between nutrition and kala-azar. This study aimed to evaluate nutritional status with kala-azar and correlate these findings with the clinical and laboratory manifestations of the disease, and zinc and retinol levels. METHODS: This was a cross-sectional study of 139 patients with kala-azar. Nutritional status classification was performed according to international recommendations. Parametric or nonparametric tests were applied whenever indicated in a two-sided test with a 5% significance level. RESULTS: Weight loss and malnutrition were more frequent in adults. Body mass index-for-age, fat area of the arm, and upper arm muscle area were significantly associated with probability of death. The presence of human immunodeficiency virus, hepatomegaly, and splenomegaly was correlated with nutritional assessment. Blood leukocyte and lymphocyte, serum creatine, and vitamin A levels were significantly higher in adult men. Vitamin A levels were highly associated with the level of hemoglobin and C-reactive protein (CRP) in multivariate analysis. All patients had reduced plasma zinc levels, but this finding had no association with the outcome variables. CONCLUSIONS: Malnutrition was correlated with severe disease and was more prevalent in older people with kala-azar. Vitamin A deficiency was associated with hemoglobin and CRP. Zinc levels were reduced in patients with kala-azar. |
format |
Article in Journal/Newspaper |
author |
Mísia Joyner de Sousa Dias Monteiro Maria Nauside Pessoa da Silva Adriana de Azevedo Paiva Dilina do Nascimento Marreiro Liania Alves Luzia Gilberto Simeone Henriques Patrícia Helen de Carvalho Rondó Ingridi de Souza Sene Ana Tárcila Alves de Almeida Carlos Henrique Nery Costa Dorcas Lamounier Costa |
author_facet |
Mísia Joyner de Sousa Dias Monteiro Maria Nauside Pessoa da Silva Adriana de Azevedo Paiva Dilina do Nascimento Marreiro Liania Alves Luzia Gilberto Simeone Henriques Patrícia Helen de Carvalho Rondó Ingridi de Souza Sene Ana Tárcila Alves de Almeida Carlos Henrique Nery Costa Dorcas Lamounier Costa |
author_sort |
Mísia Joyner de Sousa Dias Monteiro |
title |
Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil |
title_short |
Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil |
title_full |
Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil |
title_fullStr |
Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil |
title_full_unstemmed |
Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil |
title_sort |
nutritional status and vitamin a and zinc levels in patients with kala-azar in piauí, brazil |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2021 |
url |
https://doi.org/10.1590/0037-8682-0800-2020 https://doaj.org/article/c1a24d7485574e9f9b75b98c55423413 |
long_lat |
ENVELOPE(-63.733,-63.733,-64.983,-64.983) |
geographic |
Arctic Azar |
geographic_facet |
Arctic Azar |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 54 (2021) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100335&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0800-2020 https://doaj.org/article/c1a24d7485574e9f9b75b98c55423413 |
op_doi |
https://doi.org/10.1590/0037-8682-0800-2020 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
54 |
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1766341974862856192 |