Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I
Leprosy is a disabling chronic infection, with insidious onset that often evades early detection. In order to detect new leprosy cases in a timely manner, we conducted surveillance visits in some difficult-to-reach mountain areas in South West China where the disease is still prevalent. Our data con...
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ftdoajarticles:oai:doaj.org/article:c1700325be17423c9d195c31c92d59f9 2023-05-15T15:04:28+02:00 Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I Pan Qiong-Hua Zheng Zhong-Yi Yang Jun Wen Yan Yuan Lian-Chao Li Huan-Ying Steven G. Reed Malcolm S. Duthie 2013-01-01T00:00:00Z https://doi.org/10.1155/2013/352689 https://doaj.org/article/c1700325be17423c9d195c31c92d59f9 EN eng Hindawi Limited http://dx.doi.org/10.1155/2013/352689 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2013/352689 https://doaj.org/article/c1700325be17423c9d195c31c92d59f9 Journal of Tropical Medicine, Vol 2013 (2013) Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles https://doi.org/10.1155/2013/352689 2022-12-31T12:31:21Z Leprosy is a disabling chronic infection, with insidious onset that often evades early detection. In order to detect new leprosy cases in a timely manner, we conducted surveillance visits in some difficult-to-reach mountain areas in South West China where the disease is still prevalent. Our data confirm that Chinese multibacillary (MB) leprosy patients have strong antibody responses against Mycobacterium leprae antigens ND-O-BSA and LID-1. Contacts of clinically diagnosed patients were then monitored at regular intervals by both physical examinations and the laboratory determination of antibody responses in sera collected during these examinations. Elevations in antibody titers indicated the onset of MB leprosy in one of the contacts, and diagnosis was subsequently confirmed on physical examination. Our data indicate that rising antibody titers can be used as a trigger for physical examination or increased monitoring of particular individuals in order to provide early leprosy diagnosis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2013 1 5 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Pan Qiong-Hua Zheng Zhong-Yi Yang Jun Wen Yan Yuan Lian-Chao Li Huan-Ying Steven G. Reed Malcolm S. Duthie Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Leprosy is a disabling chronic infection, with insidious onset that often evades early detection. In order to detect new leprosy cases in a timely manner, we conducted surveillance visits in some difficult-to-reach mountain areas in South West China where the disease is still prevalent. Our data confirm that Chinese multibacillary (MB) leprosy patients have strong antibody responses against Mycobacterium leprae antigens ND-O-BSA and LID-1. Contacts of clinically diagnosed patients were then monitored at regular intervals by both physical examinations and the laboratory determination of antibody responses in sera collected during these examinations. Elevations in antibody titers indicated the onset of MB leprosy in one of the contacts, and diagnosis was subsequently confirmed on physical examination. Our data indicate that rising antibody titers can be used as a trigger for physical examination or increased monitoring of particular individuals in order to provide early leprosy diagnosis. |
format |
Article in Journal/Newspaper |
author |
Pan Qiong-Hua Zheng Zhong-Yi Yang Jun Wen Yan Yuan Lian-Chao Li Huan-Ying Steven G. Reed Malcolm S. Duthie |
author_facet |
Pan Qiong-Hua Zheng Zhong-Yi Yang Jun Wen Yan Yuan Lian-Chao Li Huan-Ying Steven G. Reed Malcolm S. Duthie |
author_sort |
Pan Qiong-Hua |
title |
Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
title_short |
Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
title_full |
Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
title_fullStr |
Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
title_full_unstemmed |
Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
title_sort |
early revelation of leprosy in china by sequential antibody analyses with lid-1 and pgl-i |
publisher |
Hindawi Limited |
publishDate |
2013 |
url |
https://doi.org/10.1155/2013/352689 https://doaj.org/article/c1700325be17423c9d195c31c92d59f9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2013 (2013) |
op_relation |
http://dx.doi.org/10.1155/2013/352689 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2013/352689 https://doaj.org/article/c1700325be17423c9d195c31c92d59f9 |
op_doi |
https://doi.org/10.1155/2013/352689 |
container_title |
Journal of Tropical Medicine |
container_volume |
2013 |
container_start_page |
1 |
op_container_end_page |
5 |
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1766336230415400960 |