DES-Based Biocatalysis as a Green Alternative for the l -menthyl Ester Production Based on l -menthol Acylation
The deep eutectic solvent (DES)-based biocatalysis of l -menthol acylation was designed for the production of fatty acid l -menthyl ester (FME) using fatty acid methyl ester (FAME). The biocatalytic reaction was assisted by a lipase enzyme in the DES reaction medium. ւՒ-menthol and fatty acids (e.g....
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2022
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ftdoajarticles:oai:doaj.org/article:c15d03c2873740d2a2276d5dc67f971c 2023-05-15T13:57:29+02:00 DES-Based Biocatalysis as a Green Alternative for the l -menthyl Ester Production Based on l -menthol Acylation Sabina Ion Florentina Olănescu Florina Teodorescu Robert Tincu Daniela Gheorghe Vasile I. Pârvulescu Mădălina Tudorache 2022-08-01T00:00:00Z https://doi.org/10.3390/molecules27165273 https://doaj.org/article/c15d03c2873740d2a2276d5dc67f971c EN eng MDPI AG https://www.mdpi.com/1420-3049/27/16/5273 https://doaj.org/toc/1420-3049 doi:10.3390/molecules27165273 1420-3049 https://doaj.org/article/c15d03c2873740d2a2276d5dc67f971c Molecules, Vol 27, Iss 5273, p 5273 (2022) biocatalysis DES l -menthol fatty acid l -menthyl ester (FME) immobilized lipase Organic chemistry QD241-441 article 2022 ftdoajarticles https://doi.org/10.3390/molecules27165273 2022-12-31T01:09:58Z The deep eutectic solvent (DES)-based biocatalysis of l -menthol acylation was designed for the production of fatty acid l -menthyl ester (FME) using fatty acid methyl ester (FAME). The biocatalytic reaction was assisted by a lipase enzyme in the DES reaction medium. ւՒ-menthol and fatty acids (e.g., CA—caprylic acid; OA—oleic acid; LiA—linoleic acid; and LnA—linolenic acid) were combined in the binary mixture of DES. In this way, the DES provided a nonpolar environment for requested homogeneity of a biocatalytic system with reduced impact on the environment. The screening of lipase enzyme demonstrated better performance of immobilized lipase compared with powdered lipase. The performance of the biocatalytic system was evaluated for different DES compositions (type and concentration of the acid component). l -menthol:CA = 73:27 molar ratio allowed it to reach a maximum conversion of 95% methyl lauric ester (MLE) using a NV ( Candida antarctica lipase B immobilized on acrylic resin) lipase biocatalyst. The recyclability of biocatalysts under optimum conditions of the system was also evaluated (more than 80% recovered biocatalytic activity was achieved for the tested biocatalysts after five reaction cycles). DES mixtures were characterized based on differential scanning calorimetry (DSC) and refractive index analysis. Article in Journal/Newspaper Antarc* Antarctica Directory of Open Access Journals: DOAJ Articles Molecules 27 16 5273 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
biocatalysis DES l -menthol fatty acid l -menthyl ester (FME) immobilized lipase Organic chemistry QD241-441 |
spellingShingle |
biocatalysis DES l -menthol fatty acid l -menthyl ester (FME) immobilized lipase Organic chemistry QD241-441 Sabina Ion Florentina Olănescu Florina Teodorescu Robert Tincu Daniela Gheorghe Vasile I. Pârvulescu Mădălina Tudorache DES-Based Biocatalysis as a Green Alternative for the l -menthyl Ester Production Based on l -menthol Acylation |
topic_facet |
biocatalysis DES l -menthol fatty acid l -menthyl ester (FME) immobilized lipase Organic chemistry QD241-441 |
description |
The deep eutectic solvent (DES)-based biocatalysis of l -menthol acylation was designed for the production of fatty acid l -menthyl ester (FME) using fatty acid methyl ester (FAME). The biocatalytic reaction was assisted by a lipase enzyme in the DES reaction medium. ւՒ-menthol and fatty acids (e.g., CA—caprylic acid; OA—oleic acid; LiA—linoleic acid; and LnA—linolenic acid) were combined in the binary mixture of DES. In this way, the DES provided a nonpolar environment for requested homogeneity of a biocatalytic system with reduced impact on the environment. The screening of lipase enzyme demonstrated better performance of immobilized lipase compared with powdered lipase. The performance of the biocatalytic system was evaluated for different DES compositions (type and concentration of the acid component). l -menthol:CA = 73:27 molar ratio allowed it to reach a maximum conversion of 95% methyl lauric ester (MLE) using a NV ( Candida antarctica lipase B immobilized on acrylic resin) lipase biocatalyst. The recyclability of biocatalysts under optimum conditions of the system was also evaluated (more than 80% recovered biocatalytic activity was achieved for the tested biocatalysts after five reaction cycles). DES mixtures were characterized based on differential scanning calorimetry (DSC) and refractive index analysis. |
format |
Article in Journal/Newspaper |
author |
Sabina Ion Florentina Olănescu Florina Teodorescu Robert Tincu Daniela Gheorghe Vasile I. Pârvulescu Mădălina Tudorache |
author_facet |
Sabina Ion Florentina Olănescu Florina Teodorescu Robert Tincu Daniela Gheorghe Vasile I. Pârvulescu Mădălina Tudorache |
author_sort |
Sabina Ion |
title |
DES-Based Biocatalysis as a Green Alternative for the l -menthyl Ester Production Based on l -menthol Acylation |
title_short |
DES-Based Biocatalysis as a Green Alternative for the l -menthyl Ester Production Based on l -menthol Acylation |
title_full |
DES-Based Biocatalysis as a Green Alternative for the l -menthyl Ester Production Based on l -menthol Acylation |
title_fullStr |
DES-Based Biocatalysis as a Green Alternative for the l -menthyl Ester Production Based on l -menthol Acylation |
title_full_unstemmed |
DES-Based Biocatalysis as a Green Alternative for the l -menthyl Ester Production Based on l -menthol Acylation |
title_sort |
des-based biocatalysis as a green alternative for the l -menthyl ester production based on l -menthol acylation |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/molecules27165273 https://doaj.org/article/c15d03c2873740d2a2276d5dc67f971c |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Molecules, Vol 27, Iss 5273, p 5273 (2022) |
op_relation |
https://www.mdpi.com/1420-3049/27/16/5273 https://doaj.org/toc/1420-3049 doi:10.3390/molecules27165273 1420-3049 https://doaj.org/article/c15d03c2873740d2a2276d5dc67f971c |
op_doi |
https://doi.org/10.3390/molecules27165273 |
container_title |
Molecules |
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27 |
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16 |
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5273 |
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1766265158141739008 |