Nonstructural Proteins Are Preferential Positive Selection Targets in Zika Virus and Related Flaviviruses.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Manuela Sironi, Diego Forni, Mario Clerici, Rachele Cagliani
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2016
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Barré
• Online Access: https://doi.org/10.1371/journal.pntd.0004978; https://doaj.org/article/c14ec14587b247719aadb9d5234220ae

The Flavivirus genus comprises several human pathogens such as dengue virus (DENV), Japanese encephalitis virus (JEV), and Zika virus (ZIKV). Although ZIKV usually causes mild symptoms, growing evidence is linking it to congenital birth defects and to increased risk of Guillain-Barré syndrome. ZIKV...