Maternal infection with Trypanosoma cruzi and congenital Chagas disease induce a trend to a type 1 polarization of infant immune responses to vaccines.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Nicolas Dauby, Cristina Alonso-Vega, Eduardo Suarez, Amilcar Flores, Emmanuel Hermann, Marisol Córdova, Tatiana Tellez, Faustino Torrico, Carine Truyens, Yves Carlier
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2009
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Calmette
• Online Access: https://doi.org/10.1371/journal.pntd.0000571; https://doaj.org/article/c12e928fce3646fcab97990cbb49d96a

BACKGROUND: We previously showed that newborns congenitally infected with Trypanosoma cruzi (M+B+) display a strong type 1 parasite-specific T cell immune response, whereas uninfected newborns from T. cruzi-infected mothers (M+B-) are prone to produce higher levels of proinflammatory cytokines than...