Strengthening the Bolivian pharmacovigilance system: New surveillance strategies to improve care for Chagas disease and tuberculosis.
Chagas disease (CD) and tuberculosis (TB) are important health problems in Bolivia. Current treatments for both infections require a long period of time, and adverse drug reactions (ADRs) are frequent. This study aims to strengthen the Bolivian pharmacovigilance system, focusing on CD and TB. A situ...
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ftdoajarticles:oai:doaj.org/article:c12811b6900149d0bece7980424b0bc3 2023-05-15T15:13:27+02:00 Strengthening the Bolivian pharmacovigilance system: New surveillance strategies to improve care for Chagas disease and tuberculosis. Nuria Cortes-Serra Ruth Saravia Rosse Mary Grágeda Amílcar Apaza Jorge Armando González Brenda Ríos Joaquim Gascón Faustino Torrico María-Jesús Pinazo 2020-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008370 https://doaj.org/article/c12811b6900149d0bece7980424b0bc3 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008370 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008370 https://doaj.org/article/c12811b6900149d0bece7980424b0bc3 PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008370 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008370 2022-12-31T07:48:33Z Chagas disease (CD) and tuberculosis (TB) are important health problems in Bolivia. Current treatments for both infections require a long period of time, and adverse drug reactions (ADRs) are frequent. This study aims to strengthen the Bolivian pharmacovigilance system, focusing on CD and TB. A situation analysis of pharmacovigilance in the Department of Cochabamba was performed. The use of a new local case report form (CRF) was implemented, together with the CRF established by the Unidad de Medicamentos y Tecnología en Salud (UNIMED), in several healthcare centers. Training and follow-up on drug safety monitoring and ADR reporting was provided to all health professionals involved in CD and TB treatment. A comparative analysis of the reported ADRs using the CRF provided by UNIMED, the new CRF proposal, and medical records, was also performed. Our results showed that out of all patients starting treatment for CD, 37.9% suffered ADRs according to the medical records, and 25.3% of them were classified as moderate/severe (MS). Only 47.4% of MS ADRs were reported to UNIMED. Regarding TB treatment, 9.9% of all patients suffered ADRs, 44% of them were classified as MS, and 75% of MS ADRs were reported to UNIMED. These findings show that the reinforcement of the Bolivian pharmacovigilance system is an ambitious project that should involve a long-term perspective and the engagement of national health workers and other stakeholders at all levels. Continuity and perseverance are essential to achieve a solid ADR reporting system, improving patient safety, drug efficacy and adherence to treatment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Perseverance ENVELOPE(162.200,162.200,-76.800,-76.800) PLOS Neglected Tropical Diseases 14 9 e0008370 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Nuria Cortes-Serra Ruth Saravia Rosse Mary Grágeda Amílcar Apaza Jorge Armando González Brenda Ríos Joaquim Gascón Faustino Torrico María-Jesús Pinazo Strengthening the Bolivian pharmacovigilance system: New surveillance strategies to improve care for Chagas disease and tuberculosis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Chagas disease (CD) and tuberculosis (TB) are important health problems in Bolivia. Current treatments for both infections require a long period of time, and adverse drug reactions (ADRs) are frequent. This study aims to strengthen the Bolivian pharmacovigilance system, focusing on CD and TB. A situation analysis of pharmacovigilance in the Department of Cochabamba was performed. The use of a new local case report form (CRF) was implemented, together with the CRF established by the Unidad de Medicamentos y Tecnología en Salud (UNIMED), in several healthcare centers. Training and follow-up on drug safety monitoring and ADR reporting was provided to all health professionals involved in CD and TB treatment. A comparative analysis of the reported ADRs using the CRF provided by UNIMED, the new CRF proposal, and medical records, was also performed. Our results showed that out of all patients starting treatment for CD, 37.9% suffered ADRs according to the medical records, and 25.3% of them were classified as moderate/severe (MS). Only 47.4% of MS ADRs were reported to UNIMED. Regarding TB treatment, 9.9% of all patients suffered ADRs, 44% of them were classified as MS, and 75% of MS ADRs were reported to UNIMED. These findings show that the reinforcement of the Bolivian pharmacovigilance system is an ambitious project that should involve a long-term perspective and the engagement of national health workers and other stakeholders at all levels. Continuity and perseverance are essential to achieve a solid ADR reporting system, improving patient safety, drug efficacy and adherence to treatment. |
format |
Article in Journal/Newspaper |
author |
Nuria Cortes-Serra Ruth Saravia Rosse Mary Grágeda Amílcar Apaza Jorge Armando González Brenda Ríos Joaquim Gascón Faustino Torrico María-Jesús Pinazo |
author_facet |
Nuria Cortes-Serra Ruth Saravia Rosse Mary Grágeda Amílcar Apaza Jorge Armando González Brenda Ríos Joaquim Gascón Faustino Torrico María-Jesús Pinazo |
author_sort |
Nuria Cortes-Serra |
title |
Strengthening the Bolivian pharmacovigilance system: New surveillance strategies to improve care for Chagas disease and tuberculosis. |
title_short |
Strengthening the Bolivian pharmacovigilance system: New surveillance strategies to improve care for Chagas disease and tuberculosis. |
title_full |
Strengthening the Bolivian pharmacovigilance system: New surveillance strategies to improve care for Chagas disease and tuberculosis. |
title_fullStr |
Strengthening the Bolivian pharmacovigilance system: New surveillance strategies to improve care for Chagas disease and tuberculosis. |
title_full_unstemmed |
Strengthening the Bolivian pharmacovigilance system: New surveillance strategies to improve care for Chagas disease and tuberculosis. |
title_sort |
strengthening the bolivian pharmacovigilance system: new surveillance strategies to improve care for chagas disease and tuberculosis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008370 https://doaj.org/article/c12811b6900149d0bece7980424b0bc3 |
long_lat |
ENVELOPE(162.200,162.200,-76.800,-76.800) |
geographic |
Arctic Perseverance |
geographic_facet |
Arctic Perseverance |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008370 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008370 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008370 https://doaj.org/article/c12811b6900149d0bece7980424b0bc3 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008370 |
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PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
9 |
container_start_page |
e0008370 |
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