Novel low-cost thermotherapy for cutaneous leishmaniasis in Peru.
Thermotherapy is an accepted alternative therapy for new-world cutaneous leishmaniasis, but current heat-delivery modalities are too costly to be made widely available to endemic populations. We adapted a low-cost heat pack named the HECT-CL device that delivers safe, reliable, and renewable conduct...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0002196 https://doaj.org/article/c0ed52efb14246d28f6650f1956745a4 |
id |
ftdoajarticles:oai:doaj.org/article:c0ed52efb14246d28f6650f1956745a4 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:c0ed52efb14246d28f6650f1956745a4 2023-05-15T15:05:00+02:00 Novel low-cost thermotherapy for cutaneous leishmaniasis in Peru. Braulio M Valencia David Miller Richard S Witzig Andrea K Boggild Alejandro Llanos-Cuentas 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002196 https://doaj.org/article/c0ed52efb14246d28f6650f1956745a4 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3642052?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002196 https://doaj.org/article/c0ed52efb14246d28f6650f1956745a4 PLoS Neglected Tropical Diseases, Vol 7, Iss 5, p e2196 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002196 2022-12-31T14:11:43Z Thermotherapy is an accepted alternative therapy for new-world cutaneous leishmaniasis, but current heat-delivery modalities are too costly to be made widely available to endemic populations. We adapted a low-cost heat pack named the HECT-CL device that delivers safe, reliable, and renewable conduction heat. 25 patients with cutaneous leishmaniasis completed treatment with the device at an initial temperature of 52°C ± 2°C for 3 minutes to each lesion, repeated daily for 7 days, and were followed up for 6 months by direct observation. The overall definitive clinical cure rate was 60%. Concurrently, 13 patients meeting minimally significant exclusion criteria received identical compassionate use treatment with a cumulative definitive cure rate of 68.4%, 75% for those who had experienced CL relapse after prior antimonial treatment. Therapy was well tolerated. Reversible second-degree burns occurred in two patients and no bacterial super-infections were observed. HECT-CL is a promising treatment and deserves further study to verify its safety and efficacy as adjuvant and mono- therapy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 5 e2196 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Braulio M Valencia David Miller Richard S Witzig Andrea K Boggild Alejandro Llanos-Cuentas Novel low-cost thermotherapy for cutaneous leishmaniasis in Peru. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Thermotherapy is an accepted alternative therapy for new-world cutaneous leishmaniasis, but current heat-delivery modalities are too costly to be made widely available to endemic populations. We adapted a low-cost heat pack named the HECT-CL device that delivers safe, reliable, and renewable conduction heat. 25 patients with cutaneous leishmaniasis completed treatment with the device at an initial temperature of 52°C ± 2°C for 3 minutes to each lesion, repeated daily for 7 days, and were followed up for 6 months by direct observation. The overall definitive clinical cure rate was 60%. Concurrently, 13 patients meeting minimally significant exclusion criteria received identical compassionate use treatment with a cumulative definitive cure rate of 68.4%, 75% for those who had experienced CL relapse after prior antimonial treatment. Therapy was well tolerated. Reversible second-degree burns occurred in two patients and no bacterial super-infections were observed. HECT-CL is a promising treatment and deserves further study to verify its safety and efficacy as adjuvant and mono- therapy. |
format |
Article in Journal/Newspaper |
author |
Braulio M Valencia David Miller Richard S Witzig Andrea K Boggild Alejandro Llanos-Cuentas |
author_facet |
Braulio M Valencia David Miller Richard S Witzig Andrea K Boggild Alejandro Llanos-Cuentas |
author_sort |
Braulio M Valencia |
title |
Novel low-cost thermotherapy for cutaneous leishmaniasis in Peru. |
title_short |
Novel low-cost thermotherapy for cutaneous leishmaniasis in Peru. |
title_full |
Novel low-cost thermotherapy for cutaneous leishmaniasis in Peru. |
title_fullStr |
Novel low-cost thermotherapy for cutaneous leishmaniasis in Peru. |
title_full_unstemmed |
Novel low-cost thermotherapy for cutaneous leishmaniasis in Peru. |
title_sort |
novel low-cost thermotherapy for cutaneous leishmaniasis in peru. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002196 https://doaj.org/article/c0ed52efb14246d28f6650f1956745a4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 5, p e2196 (2013) |
op_relation |
http://europepmc.org/articles/PMC3642052?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002196 https://doaj.org/article/c0ed52efb14246d28f6650f1956745a4 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002196 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
7 |
container_issue |
5 |
container_start_page |
e2196 |
_version_ |
1766336771039166464 |