Risk factors for inadequate antibody response to primary rabies vaccination in dogs under one year of age.
Ensuring the adequacy of response to rabies vaccination in dogs is important, particularly in the context of pet travel. Few studies have examined the factors associated with dogs' failure to achieve an adequate antibody titer after vaccination (0.5 IU/ml). This study evaluated rabies antibody...
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ftdoajarticles:oai:doaj.org/article:c0689e7e301f4e7f863b9b65d53b39cc 2023-05-15T15:12:54+02:00 Risk factors for inadequate antibody response to primary rabies vaccination in dogs under one year of age. Ryan M Wallace Anna Pees Jesse B Blanton Susan M Moore 2017-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005761 https://doaj.org/article/c0689e7e301f4e7f863b9b65d53b39cc EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5552338?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005761 https://doaj.org/article/c0689e7e301f4e7f863b9b65d53b39cc PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005761 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005761 2022-12-31T03:22:24Z Ensuring the adequacy of response to rabies vaccination in dogs is important, particularly in the context of pet travel. Few studies have examined the factors associated with dogs' failure to achieve an adequate antibody titer after vaccination (0.5 IU/ml). This study evaluated rabies antibody titers in dogs after primary vaccination. Dogs under one year of age whose serum was submitted to a reference laboratory for routine diagnostics, and which had no prior documented history of vaccination were enrolled (n = 8,011). Geometric mean titers (GMT) were calculated and univariate analysis was performed to assess factors associated with failure to achieve 0.5 IU/mL. Dogs vaccinated at >16 weeks of age had a significantly higher GMT compared to dogs vaccinated at a younger age (1.64 IU/ml, 1.57-1.72, ANOVA p < 0.01). There was no statistical difference in GMT between dogs vaccinated <12 weeks and dogs vaccinated 12-16 weeks (1.22 IU/ml and 1.21 IU/ml). The majority of dogs failed to reach an adequate titer within the first 3 days of primary vaccination; failure rates were also high if the interval from vaccination to titer check was greater than 90 days. Over 90% of dogs that failed primary vaccination were able to achieve adequate titers after booster vaccination. The ideal timing for blood draw is 8-30 days after primary vaccination. In the event of a failure, most dogs will achieve an adequate serologic response upon a repeat titer (in the absence of booster vaccination). Booster vaccination after failure provided the highest probability of an acceptable titer. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 7 e0005761 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ryan M Wallace Anna Pees Jesse B Blanton Susan M Moore Risk factors for inadequate antibody response to primary rabies vaccination in dogs under one year of age. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Ensuring the adequacy of response to rabies vaccination in dogs is important, particularly in the context of pet travel. Few studies have examined the factors associated with dogs' failure to achieve an adequate antibody titer after vaccination (0.5 IU/ml). This study evaluated rabies antibody titers in dogs after primary vaccination. Dogs under one year of age whose serum was submitted to a reference laboratory for routine diagnostics, and which had no prior documented history of vaccination were enrolled (n = 8,011). Geometric mean titers (GMT) were calculated and univariate analysis was performed to assess factors associated with failure to achieve 0.5 IU/mL. Dogs vaccinated at >16 weeks of age had a significantly higher GMT compared to dogs vaccinated at a younger age (1.64 IU/ml, 1.57-1.72, ANOVA p < 0.01). There was no statistical difference in GMT between dogs vaccinated <12 weeks and dogs vaccinated 12-16 weeks (1.22 IU/ml and 1.21 IU/ml). The majority of dogs failed to reach an adequate titer within the first 3 days of primary vaccination; failure rates were also high if the interval from vaccination to titer check was greater than 90 days. Over 90% of dogs that failed primary vaccination were able to achieve adequate titers after booster vaccination. The ideal timing for blood draw is 8-30 days after primary vaccination. In the event of a failure, most dogs will achieve an adequate serologic response upon a repeat titer (in the absence of booster vaccination). Booster vaccination after failure provided the highest probability of an acceptable titer. |
format |
Article in Journal/Newspaper |
author |
Ryan M Wallace Anna Pees Jesse B Blanton Susan M Moore |
author_facet |
Ryan M Wallace Anna Pees Jesse B Blanton Susan M Moore |
author_sort |
Ryan M Wallace |
title |
Risk factors for inadequate antibody response to primary rabies vaccination in dogs under one year of age. |
title_short |
Risk factors for inadequate antibody response to primary rabies vaccination in dogs under one year of age. |
title_full |
Risk factors for inadequate antibody response to primary rabies vaccination in dogs under one year of age. |
title_fullStr |
Risk factors for inadequate antibody response to primary rabies vaccination in dogs under one year of age. |
title_full_unstemmed |
Risk factors for inadequate antibody response to primary rabies vaccination in dogs under one year of age. |
title_sort |
risk factors for inadequate antibody response to primary rabies vaccination in dogs under one year of age. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005761 https://doaj.org/article/c0689e7e301f4e7f863b9b65d53b39cc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005761 (2017) |
op_relation |
http://europepmc.org/articles/PMC5552338?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005761 https://doaj.org/article/c0689e7e301f4e7f863b9b65d53b39cc |
op_doi |
https://doi.org/10.1371/journal.pntd.0005761 |
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PLOS Neglected Tropical Diseases |
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11 |
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7 |
container_start_page |
e0005761 |
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