Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010
This study estimated the incidence of and time to first antiretroviral therapy (ART) modification. This longitudinal analysis comprised a sample of 236 patients from three HIV/AIDS referral centers in Belo Horizonte, Brazil—part of a major historical cohort. Inclusion criteria were as follows: havin...
Published in: | Journal of Tropical Medicine |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Hindawi Limited
2017
|
Subjects: | |
Online Access: | https://doi.org/10.1155/2017/9612653 https://doaj.org/article/c04672e9f4004051ac6472759464bb6d |
id |
ftdoajarticles:oai:doaj.org/article:c04672e9f4004051ac6472759464bb6d |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:c04672e9f4004051ac6472759464bb6d 2023-05-15T15:08:39+02:00 Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010 Letícia Penna Braga Cássia Cristina Pinto Mendicino Edna Afonso Reis Ricardo Andrade Carmo Cristiane Menezes de Pádua 2017-01-01T00:00:00Z https://doi.org/10.1155/2017/9612653 https://doaj.org/article/c04672e9f4004051ac6472759464bb6d EN eng Hindawi Limited http://dx.doi.org/10.1155/2017/9612653 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2017/9612653 https://doaj.org/article/c04672e9f4004051ac6472759464bb6d Journal of Tropical Medicine, Vol 2017 (2017) Arctic medicine. Tropical medicine RC955-962 article 2017 ftdoajarticles https://doi.org/10.1155/2017/9612653 2022-12-31T06:22:42Z This study estimated the incidence of and time to first antiretroviral therapy (ART) modification. This longitudinal analysis comprised a sample of 236 patients from three HIV/AIDS referral centers in Belo Horizonte, Brazil—part of a major historical cohort. Inclusion criteria were as follows: having been treatment-naive patient ≥18 years old who initiated ART between 2001 and 2005 in these three referral centers. The main endpoint was time to first ART modification. Patients were followed up for five years, covering the period 2001–2010, during which time Pearson’s chi-square test was performed to compare ART modification between groups. Kaplan-Meier inverse survival curves were employed to describe the probability of ART modification and Cox proportional hazard regression was used to estimate the adjusted hazard ratio (aHR) of ART modification. Among 247 patients from the major cohort, 236 were eligible. Median follow-up time was 37.2 months and the contribution in person-months was 7,615.4 months. A total of 108 (45.8%) patients had their ART regimen modified at least once (incidence rate: 1.42 per 100 person-months). Adverse drug reactions were the main reason for ART modification. Women (aHR = 1.62; p=0.022) and patients on protease inhibitor- (PI-) based regimens (aHR = 2.70; p<0.001) were at higher risk of ART modification. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Meier ENVELOPE(-45.900,-45.900,-60.633,-60.633) Journal of Tropical Medicine 2017 1 10 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Letícia Penna Braga Cássia Cristina Pinto Mendicino Edna Afonso Reis Ricardo Andrade Carmo Cristiane Menezes de Pádua Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010 |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
This study estimated the incidence of and time to first antiretroviral therapy (ART) modification. This longitudinal analysis comprised a sample of 236 patients from three HIV/AIDS referral centers in Belo Horizonte, Brazil—part of a major historical cohort. Inclusion criteria were as follows: having been treatment-naive patient ≥18 years old who initiated ART between 2001 and 2005 in these three referral centers. The main endpoint was time to first ART modification. Patients were followed up for five years, covering the period 2001–2010, during which time Pearson’s chi-square test was performed to compare ART modification between groups. Kaplan-Meier inverse survival curves were employed to describe the probability of ART modification and Cox proportional hazard regression was used to estimate the adjusted hazard ratio (aHR) of ART modification. Among 247 patients from the major cohort, 236 were eligible. Median follow-up time was 37.2 months and the contribution in person-months was 7,615.4 months. A total of 108 (45.8%) patients had their ART regimen modified at least once (incidence rate: 1.42 per 100 person-months). Adverse drug reactions were the main reason for ART modification. Women (aHR = 1.62; p=0.022) and patients on protease inhibitor- (PI-) based regimens (aHR = 2.70; p<0.001) were at higher risk of ART modification. |
format |
Article in Journal/Newspaper |
author |
Letícia Penna Braga Cássia Cristina Pinto Mendicino Edna Afonso Reis Ricardo Andrade Carmo Cristiane Menezes de Pádua |
author_facet |
Letícia Penna Braga Cássia Cristina Pinto Mendicino Edna Afonso Reis Ricardo Andrade Carmo Cristiane Menezes de Pádua |
author_sort |
Letícia Penna Braga |
title |
Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010 |
title_short |
Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010 |
title_full |
Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010 |
title_fullStr |
Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010 |
title_full_unstemmed |
Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010 |
title_sort |
incidence and predictors of antiretroviral treatment modification in hiv-infected adults: a brazilian historical cohort from 2001 to 2010 |
publisher |
Hindawi Limited |
publishDate |
2017 |
url |
https://doi.org/10.1155/2017/9612653 https://doaj.org/article/c04672e9f4004051ac6472759464bb6d |
long_lat |
ENVELOPE(-45.900,-45.900,-60.633,-60.633) |
geographic |
Arctic Meier |
geographic_facet |
Arctic Meier |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2017 (2017) |
op_relation |
http://dx.doi.org/10.1155/2017/9612653 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2017/9612653 https://doaj.org/article/c04672e9f4004051ac6472759464bb6d |
op_doi |
https://doi.org/10.1155/2017/9612653 |
container_title |
Journal of Tropical Medicine |
container_volume |
2017 |
container_start_page |
1 |
op_container_end_page |
10 |
_version_ |
1766339963201257472 |