Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish
Iron is a trace element, essential to support life due to its inherent ability to exchange electrons with a variety of molecules. The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. During evolution, the shared requirement of micr...
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ftdoajarticles:oai:doaj.org/article:c03ae992c7e64f4c92da0964a20e3f0e 2023-05-15T18:09:48+02:00 Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish Estefanía Tarifeño-Saldivia Andrea Aguilar David Contreras Luis Mercado Byron Morales-Lange Katherine Márquez Adolfo Henríquez Camila Riquelme-Vidal Sebastian Boltana 2018-06-01T00:00:00Z https://doi.org/10.3389/fimmu.2018.01296 https://doaj.org/article/c03ae992c7e64f4c92da0964a20e3f0e EN eng Frontiers Media S.A. https://www.frontiersin.org/article/10.3389/fimmu.2018.01296/full https://doaj.org/toc/1664-3224 1664-3224 doi:10.3389/fimmu.2018.01296 https://doaj.org/article/c03ae992c7e64f4c92da0964a20e3f0e Frontiers in Immunology, Vol 9 (2018) iron overload electronic paramagnetic resonance spectroscopy nutritional immunity oxidative stress infectious pancreaticc necrosis virus RNA-seq Immunologic diseases. Allergy RC581-607 article 2018 ftdoajarticles https://doi.org/10.3389/fimmu.2018.01296 2022-12-31T03:45:06Z Iron is a trace element, essential to support life due to its inherent ability to exchange electrons with a variety of molecules. The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. During evolution, the shared requirement of micro- and macro-organisms for this important nutrient has shaped the pathogen–host relationship. Infectious pancreatic necrosis virus (IPNv) affects salmonids constituting a sanitary problem for this industry as it has an important impact on post-smolt survival. While immune modulation induced by IPNv infection has been widely characterized on Salmo salar, viral impact on iron host metabolism has not yet been elucidated. In the present work, we evaluate short-term effect of IPNv on several infected tissues from Salmo salar. We observed that IPNv displayed high tropism to headkidney, which directly correlates with a rise in oxidative stress and antiviral responses. Transcriptional profiling on headkidney showed a massive modulation of gene expression, from which biological pathways involved with iron metabolism were remarkable. Our findings suggest that IPNv infection increase oxidative stress on headkidney as a consequence of iron overload induced by a massive upregulation of genes involved in iron metabolism. Article in Journal/Newspaper Salmo salar Directory of Open Access Journals: DOAJ Articles Frontiers in Immunology 9 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
iron overload electronic paramagnetic resonance spectroscopy nutritional immunity oxidative stress infectious pancreaticc necrosis virus RNA-seq Immunologic diseases. Allergy RC581-607 |
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iron overload electronic paramagnetic resonance spectroscopy nutritional immunity oxidative stress infectious pancreaticc necrosis virus RNA-seq Immunologic diseases. Allergy RC581-607 Estefanía Tarifeño-Saldivia Andrea Aguilar David Contreras Luis Mercado Byron Morales-Lange Katherine Márquez Adolfo Henríquez Camila Riquelme-Vidal Sebastian Boltana Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish |
topic_facet |
iron overload electronic paramagnetic resonance spectroscopy nutritional immunity oxidative stress infectious pancreaticc necrosis virus RNA-seq Immunologic diseases. Allergy RC581-607 |
description |
Iron is a trace element, essential to support life due to its inherent ability to exchange electrons with a variety of molecules. The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. During evolution, the shared requirement of micro- and macro-organisms for this important nutrient has shaped the pathogen–host relationship. Infectious pancreatic necrosis virus (IPNv) affects salmonids constituting a sanitary problem for this industry as it has an important impact on post-smolt survival. While immune modulation induced by IPNv infection has been widely characterized on Salmo salar, viral impact on iron host metabolism has not yet been elucidated. In the present work, we evaluate short-term effect of IPNv on several infected tissues from Salmo salar. We observed that IPNv displayed high tropism to headkidney, which directly correlates with a rise in oxidative stress and antiviral responses. Transcriptional profiling on headkidney showed a massive modulation of gene expression, from which biological pathways involved with iron metabolism were remarkable. Our findings suggest that IPNv infection increase oxidative stress on headkidney as a consequence of iron overload induced by a massive upregulation of genes involved in iron metabolism. |
format |
Article in Journal/Newspaper |
author |
Estefanía Tarifeño-Saldivia Andrea Aguilar David Contreras Luis Mercado Byron Morales-Lange Katherine Márquez Adolfo Henríquez Camila Riquelme-Vidal Sebastian Boltana |
author_facet |
Estefanía Tarifeño-Saldivia Andrea Aguilar David Contreras Luis Mercado Byron Morales-Lange Katherine Márquez Adolfo Henríquez Camila Riquelme-Vidal Sebastian Boltana |
author_sort |
Estefanía Tarifeño-Saldivia |
title |
Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish |
title_short |
Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish |
title_full |
Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish |
title_fullStr |
Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish |
title_full_unstemmed |
Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish |
title_sort |
iron overload is associated with oxidative stress and nutritional immunity during viral infection in fish |
publisher |
Frontiers Media S.A. |
publishDate |
2018 |
url |
https://doi.org/10.3389/fimmu.2018.01296 https://doaj.org/article/c03ae992c7e64f4c92da0964a20e3f0e |
genre |
Salmo salar |
genre_facet |
Salmo salar |
op_source |
Frontiers in Immunology, Vol 9 (2018) |
op_relation |
https://www.frontiersin.org/article/10.3389/fimmu.2018.01296/full https://doaj.org/toc/1664-3224 1664-3224 doi:10.3389/fimmu.2018.01296 https://doaj.org/article/c03ae992c7e64f4c92da0964a20e3f0e |
op_doi |
https://doi.org/10.3389/fimmu.2018.01296 |
container_title |
Frontiers in Immunology |
container_volume |
9 |
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1766182463751585792 |