Neutralizing dengue antibody in pregnant Thai women and cord blood.
BACKGROUND:The WHO 'Global Strategy for Dengue Prevention and Control, 2012-2020' addresses the growing need for the treatment of dengue, and targets a 25% reduction in morbidity and 50% in mortality (using 2010 estimates as baseline). Achieving these goals requires future dengue preventio...
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ftdoajarticles:oai:doaj.org/article:bfebb580b7b94a5e86cf56035525965b 2023-05-15T15:12:35+02:00 Neutralizing dengue antibody in pregnant Thai women and cord blood. Kriangsak Khamim Weerawan Hattasingh Ananda Nisalak Jaranit Kaewkungwal Stefan Fernandez Butsaya Thaisomboonsuk Krisana Pengsaa Usa Thisyakorn 2015-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003396 https://doaj.org/article/bfebb580b7b94a5e86cf56035525965b EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4320096?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003396 https://doaj.org/article/bfebb580b7b94a5e86cf56035525965b PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003396 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003396 2022-12-31T01:36:30Z BACKGROUND:The WHO 'Global Strategy for Dengue Prevention and Control, 2012-2020' addresses the growing need for the treatment of dengue, and targets a 25% reduction in morbidity and 50% in mortality (using 2010 estimates as baseline). Achieving these goals requires future dengue prevention strategies that will employ both potential vaccines and sustainable vector-control measures. Maternally transferred dengue antibody is an important factor in determining the optimal age for dengue vaccination. OBJECTIVES:To estimate the seroprevalence of dengue antibodies among mothers living in an area of high endemicity--Ban Pong, Ratchaburi Province--and to assess maternal dengue antibodies transferred to cord blood. MATERIALS & METHODS:A cross-sectional study was conducted with 141 pregnant women who delivered at Ban Pong Hospital, Ratchaburi, Thailand. Maternal-cord paired sera were tested for dengue neutralizing (NT) antibody by PRNT50 assay. A ratio of ≥ 1:10 NT titer to dengue serotype was considered seropositive. RESULTS:Most mothers (137/141, 97.2%) had NT antibodies to at least one dengue serotype in their sera. At birth, the proportion of cord sera with NT antibodies to DEN-1, DEN-2, DEN-3, and DEN-4, were high and similar to the sera of their mothers, at 93.6%, 97.2%, 97.9%, and 92.2%, respectively. The dengue geometric mean titers (GMT) in cord blood were significantly higher than the maternal antibodies (p<0.001): highest in DEN-2, followed by DEN-3, and then DEN-1. The GMT of DEN-4 was the lowest among all four serotypes. CONCLUSIONS:Dengue infection is highly prevalent among pregnant women in this dengue-endemic area. Most of the cord blood had transferred dengue antibodies, which may have an impact on the disease burden in this population. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 2 e0003396 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Kriangsak Khamim Weerawan Hattasingh Ananda Nisalak Jaranit Kaewkungwal Stefan Fernandez Butsaya Thaisomboonsuk Krisana Pengsaa Usa Thisyakorn Neutralizing dengue antibody in pregnant Thai women and cord blood. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:The WHO 'Global Strategy for Dengue Prevention and Control, 2012-2020' addresses the growing need for the treatment of dengue, and targets a 25% reduction in morbidity and 50% in mortality (using 2010 estimates as baseline). Achieving these goals requires future dengue prevention strategies that will employ both potential vaccines and sustainable vector-control measures. Maternally transferred dengue antibody is an important factor in determining the optimal age for dengue vaccination. OBJECTIVES:To estimate the seroprevalence of dengue antibodies among mothers living in an area of high endemicity--Ban Pong, Ratchaburi Province--and to assess maternal dengue antibodies transferred to cord blood. MATERIALS & METHODS:A cross-sectional study was conducted with 141 pregnant women who delivered at Ban Pong Hospital, Ratchaburi, Thailand. Maternal-cord paired sera were tested for dengue neutralizing (NT) antibody by PRNT50 assay. A ratio of ≥ 1:10 NT titer to dengue serotype was considered seropositive. RESULTS:Most mothers (137/141, 97.2%) had NT antibodies to at least one dengue serotype in their sera. At birth, the proportion of cord sera with NT antibodies to DEN-1, DEN-2, DEN-3, and DEN-4, were high and similar to the sera of their mothers, at 93.6%, 97.2%, 97.9%, and 92.2%, respectively. The dengue geometric mean titers (GMT) in cord blood were significantly higher than the maternal antibodies (p<0.001): highest in DEN-2, followed by DEN-3, and then DEN-1. The GMT of DEN-4 was the lowest among all four serotypes. CONCLUSIONS:Dengue infection is highly prevalent among pregnant women in this dengue-endemic area. Most of the cord blood had transferred dengue antibodies, which may have an impact on the disease burden in this population. |
format |
Article in Journal/Newspaper |
author |
Kriangsak Khamim Weerawan Hattasingh Ananda Nisalak Jaranit Kaewkungwal Stefan Fernandez Butsaya Thaisomboonsuk Krisana Pengsaa Usa Thisyakorn |
author_facet |
Kriangsak Khamim Weerawan Hattasingh Ananda Nisalak Jaranit Kaewkungwal Stefan Fernandez Butsaya Thaisomboonsuk Krisana Pengsaa Usa Thisyakorn |
author_sort |
Kriangsak Khamim |
title |
Neutralizing dengue antibody in pregnant Thai women and cord blood. |
title_short |
Neutralizing dengue antibody in pregnant Thai women and cord blood. |
title_full |
Neutralizing dengue antibody in pregnant Thai women and cord blood. |
title_fullStr |
Neutralizing dengue antibody in pregnant Thai women and cord blood. |
title_full_unstemmed |
Neutralizing dengue antibody in pregnant Thai women and cord blood. |
title_sort |
neutralizing dengue antibody in pregnant thai women and cord blood. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003396 https://doaj.org/article/bfebb580b7b94a5e86cf56035525965b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003396 (2015) |
op_relation |
http://europepmc.org/articles/PMC4320096?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003396 https://doaj.org/article/bfebb580b7b94a5e86cf56035525965b |
op_doi |
https://doi.org/10.1371/journal.pntd.0003396 |
container_title |
PLOS Neglected Tropical Diseases |
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9 |
container_issue |
2 |
container_start_page |
e0003396 |
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1766343252608286720 |