Application of RNAi to Genomic Drug Target Validation in Schistosomes.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Alessandra Guidi, Nuha R Mansour, Ross A Paveley, Ian M Carruthers, Jérémy Besnard, Andrew L Hopkins, Ian H Gilbert, Quentin D Bickle
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2015
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Polo
• Online Access: https://doi.org/10.1371/journal.pntd.0003801; https://doaj.org/article/bfdc209395c44e1db0687cd2d05805dc

Concerns over the possibility of resistance developing to praziquantel (PZQ), has stimulated efforts to develop new drugs for schistosomiasis. In addition to the development of improved whole organism screens, the success of RNA interference (RNAi) in schistosomes offers great promise for the identi...