Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Schistosomiasis is second only to malaria as the most devastating parasitic disease in the world. It is caused by the helminths Schistosoma mansoni (S. mansoni), S. haematobium, or S. japonicum. Typically, patients with schistosomiasis suffer from symptoms of liver fibrosis and hepatosplenomegaly. C...
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ftdoajarticles:oai:doaj.org/article:bfc435f7bb694de1812445c116c99e1b 2023-05-15T15:06:55+02:00 Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo. Ho Yin Pekkle Lam Ting-Ruei Liang Shih-Yi Peng 2021-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009554 https://doaj.org/article/bfc435f7bb694de1812445c116c99e1b EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009554 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009554 https://doaj.org/article/bfc435f7bb694de1812445c116c99e1b PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009554 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009554 2022-12-31T11:50:06Z Schistosomiasis is second only to malaria as the most devastating parasitic disease in the world. It is caused by the helminths Schistosoma mansoni (S. mansoni), S. haematobium, or S. japonicum. Typically, patients with schistosomiasis suffer from symptoms of liver fibrosis and hepatosplenomegaly. Currently, patients were treated with praziquantel. Although praziquantel effectively kills the worm, it cannot prevent re-infection or resolve liver fibrosis. Also, current treatment options are not ample to completely cure liver fibrosis and splenic damages. Moreover, resistance of praziquantel has been reported in vivo and in vitro studies. Therefore, finding new effective treatment agents is urgently needed. Schisandrin B (Sch B) of Schisandra chinensis has been shown to protect against different liver injuries including fatty liver disease, hepatotoxicity, fibrosis, and hepatoma. We herein investigate the potential of using Sch B to treat S. mansoni-induced liver fibrosis. Results from the present study demonstrate that Sch B is beneficial in treating S. mansoni-induced liver fibrosis and splenic damages, through inhibition of inflammasome activation and apoptosis; and aside from that regulates host immune responses. Besides, Sch B treatment damages male adult worm in the mice, consequently helps to reduce egg production and lessen the parasite burden. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 6 e0009554 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ho Yin Pekkle Lam Ting-Ruei Liang Shih-Yi Peng Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Schistosomiasis is second only to malaria as the most devastating parasitic disease in the world. It is caused by the helminths Schistosoma mansoni (S. mansoni), S. haematobium, or S. japonicum. Typically, patients with schistosomiasis suffer from symptoms of liver fibrosis and hepatosplenomegaly. Currently, patients were treated with praziquantel. Although praziquantel effectively kills the worm, it cannot prevent re-infection or resolve liver fibrosis. Also, current treatment options are not ample to completely cure liver fibrosis and splenic damages. Moreover, resistance of praziquantel has been reported in vivo and in vitro studies. Therefore, finding new effective treatment agents is urgently needed. Schisandrin B (Sch B) of Schisandra chinensis has been shown to protect against different liver injuries including fatty liver disease, hepatotoxicity, fibrosis, and hepatoma. We herein investigate the potential of using Sch B to treat S. mansoni-induced liver fibrosis. Results from the present study demonstrate that Sch B is beneficial in treating S. mansoni-induced liver fibrosis and splenic damages, through inhibition of inflammasome activation and apoptosis; and aside from that regulates host immune responses. Besides, Sch B treatment damages male adult worm in the mice, consequently helps to reduce egg production and lessen the parasite burden. |
format |
Article in Journal/Newspaper |
author |
Ho Yin Pekkle Lam Ting-Ruei Liang Shih-Yi Peng |
author_facet |
Ho Yin Pekkle Lam Ting-Ruei Liang Shih-Yi Peng |
author_sort |
Ho Yin Pekkle Lam |
title |
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo. |
title_short |
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo. |
title_full |
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo. |
title_fullStr |
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo. |
title_full_unstemmed |
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo. |
title_sort |
ameliorative effects of schisandrin b on schistosoma mansoni-induced hepatic fibrosis in vivo. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009554 https://doaj.org/article/bfc435f7bb694de1812445c116c99e1b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009554 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009554 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009554 https://doaj.org/article/bfc435f7bb694de1812445c116c99e1b |
op_doi |
https://doi.org/10.1371/journal.pntd.0009554 |
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PLOS Neglected Tropical Diseases |
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15 |
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6 |
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e0009554 |
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