Prognostic value of plasma C-reactive protein in the evaluation of paraquat poisoning patients

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Zong Ning, Yu-Long Bai, Hua Lu, Kang-Lin Mo
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2015
• Subjects: Paraquat poisoning; C-reactive protein; Prognosis; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic; Meier
• Online Access: https://doi.org/10.1016/j.apjtb.2015.06.011; https://doaj.org/article/bf957c230a24429a854bbef144287cf5

Objective: To investigate the prognostic value of plasma C-reactive protein (CRP) level in patients with paraquat poisoning. Methods: This study included 162 patients with paraquat poisoning. The data of plasma paraquat, CRP level and arterial blood gas were analyzed. Cox regression analysis was applied to evaluate the risk factors of prognosis. Receiver operating characteristics curve analysis and area under curve were used to calculate the predictive power of significant variable. Differences in patient survival were determined using the Kaplan–Meier method and a log-rank test. Results: Plasma CRP level was significantly increased in non-survival patients compared with survival patients (P < 0.05), and positively correlated with plasma paraquat level (P < 0.05). Cox regression analysis revealed that plasma CRP level was an independent prognostic marker of mortality within 30 days. The receiver operating characteristics curve analysis indicated that area under curve of plasma CRP level was 0.867 (95% CI: 0.81–0.93), and the cut-off value was 18 mg/L, and patients with CRP level over this value had a poor survival time compared with those with less than this value. Conclusions: These results suggest that plasma CRP level is distinct increased in patients with paraquat poisoning, and the plasma CRP level may be useful for the prediction of prognosis in paraquat poisoning.