Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106

• Published in: Marine Drugs
• Main Authors: Bin Wu, Vanessa Oesker, Jutta Wiese, Rolf Schmaljohann, Johannes F. Imhoff
• Format: Article in Journal/Newspaper
• Language: English
• Published: MDPI AG 2014
• Subjects: pyridones; antibiotic; Trichoderma; marine fungus; Biology (General); QH301-705.5; Greenland
• Online Access: https://doi.org/10.3390/md12031208; https://doaj.org/article/bf7d21969c9d4ade9721be859c13069d

Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC50 values of 24 μM and 4 μM, respectively.