Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii.
Although Q fever has been widely reported in the rural areas of China, there is a paucity of data on the epidemiology and clinical characteristics of this disease in large metropolitan cities. In this study, we profile the epidemiology and clinical manifestations of Q fever from a tertiary hospital...
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ftdoajarticles:oai:doaj.org/article:bec298439a5648da9e4668ba2e7f9835 2023-05-15T15:12:44+02:00 Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii. Fanfan Xing Haiyan Ye Chaowen Deng Linlin Sun Yanfei Yuan Qianyun Lu Jin Yang Simon K F Lo Ruiping Zhang Jonathan H K Chen Jasper F W Chan Susanna K P Lau Patrick C Y Woo 2022-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010364 https://doaj.org/article/bec298439a5648da9e4668ba2e7f9835 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010364 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010364 https://doaj.org/article/bec298439a5648da9e4668ba2e7f9835 PLoS Neglected Tropical Diseases, Vol 16, Iss 4, p e0010364 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010364 2022-12-30T21:49:03Z Although Q fever has been widely reported in the rural areas of China, there is a paucity of data on the epidemiology and clinical characteristics of this disease in large metropolitan cities. In this study, we profile the epidemiology and clinical manifestations of Q fever from a tertiary hospital in Shenzhen, a Southern Chinese metropolitan city with a large immigrant population from other parts of China. A total of 14 patients were confirmed to have Q fever during a nine-year-and-six-month period, five of whom were retrospectively diagnosed during case review or incidentally picked up because of another research project on unexplained fever without localizing features. Some patients had the typical exposure histories and clinical features, while a few other patients had rare manifestations of Q fever, including one with heart failure and diffuse intracapillary proliferative glomerulonephritis, a patient presenting with a spontaneous bacterial peritonitis-like syndrome, and another one with concomitant Q fever and brucellosis. Using a combination of clinical manifestation, inflammatory marker levels, echocardiographic findings and serological or molecular test results, nine, three and two patients were diagnosed to have acute, chronic and convalescent Q fever, respectively. Seven, five and two patients were diagnosed to have Q fever by serological test, nested real-time PCR and next-generation sequencing respectively. Diverse and atypical manifestations are associated with Q fever. The incidence of Q fever is likely to be underestimated. Next-generation sequencing is becoming an important diagnostic modality for culture-negative infections, particularly those that the physicians fail to recognize clinically, such as Q fever. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 4 e0010364 |
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Directory of Open Access Journals: DOAJ Articles |
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topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Fanfan Xing Haiyan Ye Chaowen Deng Linlin Sun Yanfei Yuan Qianyun Lu Jin Yang Simon K F Lo Ruiping Zhang Jonathan H K Chen Jasper F W Chan Susanna K P Lau Patrick C Y Woo Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Although Q fever has been widely reported in the rural areas of China, there is a paucity of data on the epidemiology and clinical characteristics of this disease in large metropolitan cities. In this study, we profile the epidemiology and clinical manifestations of Q fever from a tertiary hospital in Shenzhen, a Southern Chinese metropolitan city with a large immigrant population from other parts of China. A total of 14 patients were confirmed to have Q fever during a nine-year-and-six-month period, five of whom were retrospectively diagnosed during case review or incidentally picked up because of another research project on unexplained fever without localizing features. Some patients had the typical exposure histories and clinical features, while a few other patients had rare manifestations of Q fever, including one with heart failure and diffuse intracapillary proliferative glomerulonephritis, a patient presenting with a spontaneous bacterial peritonitis-like syndrome, and another one with concomitant Q fever and brucellosis. Using a combination of clinical manifestation, inflammatory marker levels, echocardiographic findings and serological or molecular test results, nine, three and two patients were diagnosed to have acute, chronic and convalescent Q fever, respectively. Seven, five and two patients were diagnosed to have Q fever by serological test, nested real-time PCR and next-generation sequencing respectively. Diverse and atypical manifestations are associated with Q fever. The incidence of Q fever is likely to be underestimated. Next-generation sequencing is becoming an important diagnostic modality for culture-negative infections, particularly those that the physicians fail to recognize clinically, such as Q fever. |
format |
Article in Journal/Newspaper |
author |
Fanfan Xing Haiyan Ye Chaowen Deng Linlin Sun Yanfei Yuan Qianyun Lu Jin Yang Simon K F Lo Ruiping Zhang Jonathan H K Chen Jasper F W Chan Susanna K P Lau Patrick C Y Woo |
author_facet |
Fanfan Xing Haiyan Ye Chaowen Deng Linlin Sun Yanfei Yuan Qianyun Lu Jin Yang Simon K F Lo Ruiping Zhang Jonathan H K Chen Jasper F W Chan Susanna K P Lau Patrick C Y Woo |
author_sort |
Fanfan Xing |
title |
Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii. |
title_short |
Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii. |
title_full |
Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii. |
title_fullStr |
Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii. |
title_full_unstemmed |
Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii. |
title_sort |
diverse and atypical manifestations of q fever in a metropolitan city hospital: emerging role of next-generation sequencing for laboratory diagnosis of coxiella burnetii. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010364 https://doaj.org/article/bec298439a5648da9e4668ba2e7f9835 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 4, p e0010364 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010364 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010364 https://doaj.org/article/bec298439a5648da9e4668ba2e7f9835 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010364 |
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PLOS Neglected Tropical Diseases |
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16 |
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4 |
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e0010364 |
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