Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process.
Genomic data generated from clinical Vibrio cholerae O1 isolates collected over a five year period in an area of Kolkata, India with seasonal cholera outbreaks allowed a detailed genetic analysis of serotype switching that occurred from Ogawa to Inaba and back to Ogawa. The change from Ogawa to Inab...
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ftdoajarticles:oai:doaj.org/article:bea359d7e1f448deacc8b0824e99c638 2023-05-15T15:03:23+02:00 Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process. Stefan L Karlsson Nicholas Thomson Ankur Mutreja Thomas Connor Dipika Sur Mohammad Ali John Clemens Gordon Dougan Jan Holmgren Michael Lebens 2016-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005044 https://doaj.org/article/bea359d7e1f448deacc8b0824e99c638 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5051702?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005044 https://doaj.org/article/bea359d7e1f448deacc8b0824e99c638 PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005044 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005044 2022-12-31T00:20:15Z Genomic data generated from clinical Vibrio cholerae O1 isolates collected over a five year period in an area of Kolkata, India with seasonal cholera outbreaks allowed a detailed genetic analysis of serotype switching that occurred from Ogawa to Inaba and back to Ogawa. The change from Ogawa to Inaba resulted from mutational disruption of the methyltransferase encoded by the wbeT gene. Re-emergence of the Ogawa serotype was found to result either from expansion of an already existing Ogawa clade or reversion of the mutation in an Inaba clade. Our data suggests that such transitions are not random events but rather driven by as yet unidentified selection mechanisms based on differences in the structure of the O1 antigen or in the serotype-determining wbeT gene. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 10 e0005044 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Stefan L Karlsson Nicholas Thomson Ankur Mutreja Thomas Connor Dipika Sur Mohammad Ali John Clemens Gordon Dougan Jan Holmgren Michael Lebens Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Genomic data generated from clinical Vibrio cholerae O1 isolates collected over a five year period in an area of Kolkata, India with seasonal cholera outbreaks allowed a detailed genetic analysis of serotype switching that occurred from Ogawa to Inaba and back to Ogawa. The change from Ogawa to Inaba resulted from mutational disruption of the methyltransferase encoded by the wbeT gene. Re-emergence of the Ogawa serotype was found to result either from expansion of an already existing Ogawa clade or reversion of the mutation in an Inaba clade. Our data suggests that such transitions are not random events but rather driven by as yet unidentified selection mechanisms based on differences in the structure of the O1 antigen or in the serotype-determining wbeT gene. |
format |
Article in Journal/Newspaper |
author |
Stefan L Karlsson Nicholas Thomson Ankur Mutreja Thomas Connor Dipika Sur Mohammad Ali John Clemens Gordon Dougan Jan Holmgren Michael Lebens |
author_facet |
Stefan L Karlsson Nicholas Thomson Ankur Mutreja Thomas Connor Dipika Sur Mohammad Ali John Clemens Gordon Dougan Jan Holmgren Michael Lebens |
author_sort |
Stefan L Karlsson |
title |
Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process. |
title_short |
Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process. |
title_full |
Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process. |
title_fullStr |
Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process. |
title_full_unstemmed |
Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process. |
title_sort |
retrospective analysis of serotype switching of vibrio cholerae o1 in a cholera endemic region shows it is a non-random process. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0005044 https://doaj.org/article/bea359d7e1f448deacc8b0824e99c638 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
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PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005044 (2016) |
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http://europepmc.org/articles/PMC5051702?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005044 https://doaj.org/article/bea359d7e1f448deacc8b0824e99c638 |
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https://doi.org/10.1371/journal.pntd.0005044 |
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PLOS Neglected Tropical Diseases |
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10 |
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10 |
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e0005044 |
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