Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2

• Published in: Journal of Venomous Animals and Toxins including Tropical Diseases
• Main Authors: Vitor Pedro Targhetta, Mariana Abrantes Amaral, Niels Olsen Saraiva Camara
• Format: Article in Journal/Newspaper
• Language: English
• Published: SciELO 2021
• Subjects: SARS-CoV-2; Mitochondria; Innate receptors; Cytokine storm; Arctic medicine. Tropical medicine; RC955-962; Toxicology. Poisons; RA1190-1270; Zoology; QL1-991; Arctic
• Online Access: https://doi.org/10.1590/1678-9199-jvatitd-2020-0183; https://doaj.org/article/be993ae6df5e4d899d7db2d14dd222eb

Abstract The COVID-19 pandemic brought attention to studies about viral infections and their impact on the cell machinery. SARS-CoV-2, for example, invades the host cells by ACE2 interaction and possibly hijacks the mitochondria. To better understand the disease and to propose novel treatments, crucial aspects of SARS-CoV-2 enrolment with host mitochondria must be studied. The replicative process of the virus leads to consequences in mitochondrial function, and cell metabolism. The hijacking of mitochondria, on the other hand, can drive the extrusion of mitochondrial DNA (mtDNA) to the cytosol. Extracellular mtDNA evoke robust proinflammatory responses once detected, that may act in different pathways, eliciting important immune responses. However, few receptors are validated and are able to detect and respond to mtDNA. In this review, we propose that the mtDNA and its detection might be important in the immune process generated by SARS-CoV-2 and that this mechanism might be important in the lung pathogenesis seen in clinical symptoms. Therefore, investigating the mtDNA receptors and their signaling pathways might provide important clues for therapeutic interventions.