Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2
Abstract The COVID-19 pandemic brought attention to studies about viral infections and their impact on the cell machinery. SARS-CoV-2, for example, invades the host cells by ACE2 interaction and possibly hijacks the mitochondria. To better understand the disease and to propose novel treatments, cruc...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Online Access: | https://doi.org/10.1590/1678-9199-jvatitd-2020-0183 https://doaj.org/article/be993ae6df5e4d899d7db2d14dd222eb |
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ftdoajarticles:oai:doaj.org/article:be993ae6df5e4d899d7db2d14dd222eb 2023-05-15T15:06:01+02:00 Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2 Vitor Pedro Targhetta Mariana Abrantes Amaral Niels Olsen Saraiva Camara 2021-08-01T00:00:00Z https://doi.org/10.1590/1678-9199-jvatitd-2020-0183 https://doaj.org/article/be993ae6df5e4d899d7db2d14dd222eb EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992021000100207&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2020-0183 https://doaj.org/article/be993ae6df5e4d899d7db2d14dd222eb Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 27 (2021) SARS-CoV-2 Mitochondria Innate receptors Cytokine storm Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2021 ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-2020-0183 2022-12-31T11:09:25Z Abstract The COVID-19 pandemic brought attention to studies about viral infections and their impact on the cell machinery. SARS-CoV-2, for example, invades the host cells by ACE2 interaction and possibly hijacks the mitochondria. To better understand the disease and to propose novel treatments, crucial aspects of SARS-CoV-2 enrolment with host mitochondria must be studied. The replicative process of the virus leads to consequences in mitochondrial function, and cell metabolism. The hijacking of mitochondria, on the other hand, can drive the extrusion of mitochondrial DNA (mtDNA) to the cytosol. Extracellular mtDNA evoke robust proinflammatory responses once detected, that may act in different pathways, eliciting important immune responses. However, few receptors are validated and are able to detect and respond to mtDNA. In this review, we propose that the mtDNA and its detection might be important in the immune process generated by SARS-CoV-2 and that this mechanism might be important in the lung pathogenesis seen in clinical symptoms. Therefore, investigating the mtDNA receptors and their signaling pathways might provide important clues for therapeutic interventions. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 27 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
SARS-CoV-2 Mitochondria Innate receptors Cytokine storm Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
SARS-CoV-2 Mitochondria Innate receptors Cytokine storm Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Vitor Pedro Targhetta Mariana Abrantes Amaral Niels Olsen Saraiva Camara Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2 |
topic_facet |
SARS-CoV-2 Mitochondria Innate receptors Cytokine storm Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract The COVID-19 pandemic brought attention to studies about viral infections and their impact on the cell machinery. SARS-CoV-2, for example, invades the host cells by ACE2 interaction and possibly hijacks the mitochondria. To better understand the disease and to propose novel treatments, crucial aspects of SARS-CoV-2 enrolment with host mitochondria must be studied. The replicative process of the virus leads to consequences in mitochondrial function, and cell metabolism. The hijacking of mitochondria, on the other hand, can drive the extrusion of mitochondrial DNA (mtDNA) to the cytosol. Extracellular mtDNA evoke robust proinflammatory responses once detected, that may act in different pathways, eliciting important immune responses. However, few receptors are validated and are able to detect and respond to mtDNA. In this review, we propose that the mtDNA and its detection might be important in the immune process generated by SARS-CoV-2 and that this mechanism might be important in the lung pathogenesis seen in clinical symptoms. Therefore, investigating the mtDNA receptors and their signaling pathways might provide important clues for therapeutic interventions. |
format |
Article in Journal/Newspaper |
author |
Vitor Pedro Targhetta Mariana Abrantes Amaral Niels Olsen Saraiva Camara |
author_facet |
Vitor Pedro Targhetta Mariana Abrantes Amaral Niels Olsen Saraiva Camara |
author_sort |
Vitor Pedro Targhetta |
title |
Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2 |
title_short |
Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2 |
title_full |
Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2 |
title_fullStr |
Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2 |
title_full_unstemmed |
Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2 |
title_sort |
through dna sensors and hidden mitochondrial effects of sars-cov-2 |
publisher |
SciELO |
publishDate |
2021 |
url |
https://doi.org/10.1590/1678-9199-jvatitd-2020-0183 https://doaj.org/article/be993ae6df5e4d899d7db2d14dd222eb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 27 (2021) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992021000100207&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2020-0183 https://doaj.org/article/be993ae6df5e4d899d7db2d14dd222eb |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-2020-0183 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
27 |
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1766337690945454080 |