Fast evolution from precast bricks: genomics of young freshwater populations of threespine stickleback Gasterosteus aculeatus.
Adaptation is driven by natural selection; however, many adaptations are caused by weak selection acting over large timescales, complicating its study. Therefore, it is rarely possible to study selection comprehensively in natural environments. The threespine stickleback (Gasterosteus aculeatus) is...
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ftdoajarticles:oai:doaj.org/article:be877d98627b4c16b04075da69368bf3 2023-05-15T18:43:55+02:00 Fast evolution from precast bricks: genomics of young freshwater populations of threespine stickleback Gasterosteus aculeatus. Nadezhda V Terekhanova Maria D Logacheva Aleksey A Penin Tatiana V Neretina Anna E Barmintseva Georgii A Bazykin Alexey S Kondrashov Nikolai S Mugue 2014-10-01T00:00:00Z https://doi.org/10.1371/journal.pgen.1004696 https://doaj.org/article/be877d98627b4c16b04075da69368bf3 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4191950?pdf=render https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404 1553-7390 1553-7404 doi:10.1371/journal.pgen.1004696 https://doaj.org/article/be877d98627b4c16b04075da69368bf3 PLoS Genetics, Vol 10, Iss 10, p e1004696 (2014) Genetics QH426-470 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pgen.1004696 2022-12-30T23:27:20Z Adaptation is driven by natural selection; however, many adaptations are caused by weak selection acting over large timescales, complicating its study. Therefore, it is rarely possible to study selection comprehensively in natural environments. The threespine stickleback (Gasterosteus aculeatus) is a well-studied model organism with a short generation time, small genome size, and many genetic and genomic tools available. Within this originally marine species, populations have recurrently adapted to freshwater all over its range. This evolution involved extensive parallelism: pre-existing alleles that adapt sticklebacks to freshwater habitats, but are also present at low frequencies in marine populations, have been recruited repeatedly. While a number of genomic regions responsible for this adaptation have been identified, the details of selection remain poorly understood. Using whole-genome resequencing, we compare pooled genomic samples from marine and freshwater populations of the White Sea basin, and identify 19 short genomic regions that are highly divergent between them, including three known inversions. 17 of these regions overlap protein-coding genes, including a number of genes with predicted functions that are relevant for adaptation to the freshwater environment. We then analyze four additional independently derived young freshwater populations of known ages, two natural and two artificially established, and use the observed shifts of allelic frequencies to estimate the strength of positive selection. Adaptation turns out to be quite rapid, indicating strong selection acting simultaneously at multiple regions of the genome, with selection coefficients of up to 0.27. High divergence between marine and freshwater genotypes, lack of reduction in polymorphism in regions responsible for adaptation, and high frequencies of freshwater alleles observed even in young freshwater populations are all consistent with rapid assembly of G. aculeatus freshwater genotypes from pre-existing genomic regions of adaptive ... Article in Journal/Newspaper White Sea Directory of Open Access Journals: DOAJ Articles White Sea PLoS Genetics 10 10 e1004696 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Genetics QH426-470 |
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Genetics QH426-470 Nadezhda V Terekhanova Maria D Logacheva Aleksey A Penin Tatiana V Neretina Anna E Barmintseva Georgii A Bazykin Alexey S Kondrashov Nikolai S Mugue Fast evolution from precast bricks: genomics of young freshwater populations of threespine stickleback Gasterosteus aculeatus. |
topic_facet |
Genetics QH426-470 |
description |
Adaptation is driven by natural selection; however, many adaptations are caused by weak selection acting over large timescales, complicating its study. Therefore, it is rarely possible to study selection comprehensively in natural environments. The threespine stickleback (Gasterosteus aculeatus) is a well-studied model organism with a short generation time, small genome size, and many genetic and genomic tools available. Within this originally marine species, populations have recurrently adapted to freshwater all over its range. This evolution involved extensive parallelism: pre-existing alleles that adapt sticklebacks to freshwater habitats, but are also present at low frequencies in marine populations, have been recruited repeatedly. While a number of genomic regions responsible for this adaptation have been identified, the details of selection remain poorly understood. Using whole-genome resequencing, we compare pooled genomic samples from marine and freshwater populations of the White Sea basin, and identify 19 short genomic regions that are highly divergent between them, including three known inversions. 17 of these regions overlap protein-coding genes, including a number of genes with predicted functions that are relevant for adaptation to the freshwater environment. We then analyze four additional independently derived young freshwater populations of known ages, two natural and two artificially established, and use the observed shifts of allelic frequencies to estimate the strength of positive selection. Adaptation turns out to be quite rapid, indicating strong selection acting simultaneously at multiple regions of the genome, with selection coefficients of up to 0.27. High divergence between marine and freshwater genotypes, lack of reduction in polymorphism in regions responsible for adaptation, and high frequencies of freshwater alleles observed even in young freshwater populations are all consistent with rapid assembly of G. aculeatus freshwater genotypes from pre-existing genomic regions of adaptive ... |
format |
Article in Journal/Newspaper |
author |
Nadezhda V Terekhanova Maria D Logacheva Aleksey A Penin Tatiana V Neretina Anna E Barmintseva Georgii A Bazykin Alexey S Kondrashov Nikolai S Mugue |
author_facet |
Nadezhda V Terekhanova Maria D Logacheva Aleksey A Penin Tatiana V Neretina Anna E Barmintseva Georgii A Bazykin Alexey S Kondrashov Nikolai S Mugue |
author_sort |
Nadezhda V Terekhanova |
title |
Fast evolution from precast bricks: genomics of young freshwater populations of threespine stickleback Gasterosteus aculeatus. |
title_short |
Fast evolution from precast bricks: genomics of young freshwater populations of threespine stickleback Gasterosteus aculeatus. |
title_full |
Fast evolution from precast bricks: genomics of young freshwater populations of threespine stickleback Gasterosteus aculeatus. |
title_fullStr |
Fast evolution from precast bricks: genomics of young freshwater populations of threespine stickleback Gasterosteus aculeatus. |
title_full_unstemmed |
Fast evolution from precast bricks: genomics of young freshwater populations of threespine stickleback Gasterosteus aculeatus. |
title_sort |
fast evolution from precast bricks: genomics of young freshwater populations of threespine stickleback gasterosteus aculeatus. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pgen.1004696 https://doaj.org/article/be877d98627b4c16b04075da69368bf3 |
geographic |
White Sea |
geographic_facet |
White Sea |
genre |
White Sea |
genre_facet |
White Sea |
op_source |
PLoS Genetics, Vol 10, Iss 10, p e1004696 (2014) |
op_relation |
http://europepmc.org/articles/PMC4191950?pdf=render https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404 1553-7390 1553-7404 doi:10.1371/journal.pgen.1004696 https://doaj.org/article/be877d98627b4c16b04075da69368bf3 |
op_doi |
https://doi.org/10.1371/journal.pgen.1004696 |
container_title |
PLoS Genetics |
container_volume |
10 |
container_issue |
10 |
container_start_page |
e1004696 |
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1766234447122792448 |