Diversity analysis of MSP1 identifies conserved epitope organization in block 2 amidst high sequence variability in Indian Plasmodium falciparum isolates

• Published in: Malaria Journal
• Main Authors: Sharmistha Ghoshal, Pragya Gajendra, Sumana Datta Kanjilal, Mitashree Mitra, Sanghamitra Sengupta
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2018
• Subjects: Plasmodium falciparum; MSP1; Genetic diversity; Multiclonal infection; Epitope organization; India; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Indel’; Indian
• Online Access: https://doi.org/10.1186/s12936-018-2592-y; https://doaj.org/article/be801f5733fe4a75a4a9ce54d29a0fa1

Abstract Background Despite its immunogenicity, the polymorphic nature of merozoite surface protein 1, an important vaccine candidate for Plasmodium falciparum malaria, remains a concern. This study analyses the impact of genetic variability and parasite population structure on epitope organization...