Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010
Abstract Background The annual incidence and temporal trend of severe malaria and community-acquired bacteraemia during a four-year period in Muheza, Tanzania was assessed. Methods Data on severely ill febrile children aged 2 months to 14 years from three prospective studies conducted at Muheza Dist...
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ftdoajarticles:oai:doaj.org/article:be7f8c608f1445fca4db51aaf1dc0b9a 2023-05-15T15:13:54+02:00 Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 Kim Deok Ryun Mwambuli Abraham Dondorp Arjen M Hendriksen Ilse CE Nadjm Behzad Amos Ben Mtove George Ochiai R Leon Clemens John D von Seidlein Lorenz Reyburn Hugh Deen Jacqueline 2011-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-320 https://doaj.org/article/be7f8c608f1445fca4db51aaf1dc0b9a EN eng BMC http://www.malariajournal.com/content/10/1/320 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-320 1475-2875 https://doaj.org/article/be7f8c608f1445fca4db51aaf1dc0b9a Malaria Journal, Vol 10, Iss 1, p 320 (2011) Bacteraemia malaria invasive non-typhoidal salmonellosis typhoid fever Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-320 2022-12-30T21:57:49Z Abstract Background The annual incidence and temporal trend of severe malaria and community-acquired bacteraemia during a four-year period in Muheza, Tanzania was assessed. Methods Data on severely ill febrile children aged 2 months to 14 years from three prospective studies conducted at Muheza District Hospital from 2006 to 2010 was pooled and analysed. On admission, each enrolled child had a thin and thick blood film and at least one rapid diagnostic test for falciparum malaria, as well as a blood culture. The annual incidence of bacteraemia and severe malaria among children coming from Muheza was calculated and their temporal trend was assessed. Results Overall, 1, 898 severe falciparum malaria and 684 bacteraemia cases were included. Of these, 1, 356 (71%) and 482 (71%), respectively, were from the referral population of Muheza. The incidence of falciparum malaria and all-cause bacteraemia in Muheza decreased five-fold and three-fold, respectively, from the first to the fourth year of surveillance (p < 0.0001). During this period, the median ages of children from Muheza admitted with severe malaria increased from 1.7 to 2.5 years (p < 0.0001). The reduction in all-cause bacteraemia was mainly driven by the 11-fold decline in the incidence of non-typhoidal salmonellosis. The annual incidences of Haemophilus influenzae and pneumococcal invasive bacterial infections decreased as well but were much fewer in number. Conclusions These results add to the growing evidence of the decline in malaria associated with a decrease in non-typhoidal salmonellosis and possibly other bacteraemias. Malarial prevention and control strategies may provide a greater benefit than the mere reduction of malaria alone. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 1 320 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Bacteraemia malaria invasive non-typhoidal salmonellosis typhoid fever Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Bacteraemia malaria invasive non-typhoidal salmonellosis typhoid fever Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kim Deok Ryun Mwambuli Abraham Dondorp Arjen M Hendriksen Ilse CE Nadjm Behzad Amos Ben Mtove George Ochiai R Leon Clemens John D von Seidlein Lorenz Reyburn Hugh Deen Jacqueline Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 |
topic_facet |
Bacteraemia malaria invasive non-typhoidal salmonellosis typhoid fever Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The annual incidence and temporal trend of severe malaria and community-acquired bacteraemia during a four-year period in Muheza, Tanzania was assessed. Methods Data on severely ill febrile children aged 2 months to 14 years from three prospective studies conducted at Muheza District Hospital from 2006 to 2010 was pooled and analysed. On admission, each enrolled child had a thin and thick blood film and at least one rapid diagnostic test for falciparum malaria, as well as a blood culture. The annual incidence of bacteraemia and severe malaria among children coming from Muheza was calculated and their temporal trend was assessed. Results Overall, 1, 898 severe falciparum malaria and 684 bacteraemia cases were included. Of these, 1, 356 (71%) and 482 (71%), respectively, were from the referral population of Muheza. The incidence of falciparum malaria and all-cause bacteraemia in Muheza decreased five-fold and three-fold, respectively, from the first to the fourth year of surveillance (p < 0.0001). During this period, the median ages of children from Muheza admitted with severe malaria increased from 1.7 to 2.5 years (p < 0.0001). The reduction in all-cause bacteraemia was mainly driven by the 11-fold decline in the incidence of non-typhoidal salmonellosis. The annual incidences of Haemophilus influenzae and pneumococcal invasive bacterial infections decreased as well but were much fewer in number. Conclusions These results add to the growing evidence of the decline in malaria associated with a decrease in non-typhoidal salmonellosis and possibly other bacteraemias. Malarial prevention and control strategies may provide a greater benefit than the mere reduction of malaria alone. |
format |
Article in Journal/Newspaper |
author |
Kim Deok Ryun Mwambuli Abraham Dondorp Arjen M Hendriksen Ilse CE Nadjm Behzad Amos Ben Mtove George Ochiai R Leon Clemens John D von Seidlein Lorenz Reyburn Hugh Deen Jacqueline |
author_facet |
Kim Deok Ryun Mwambuli Abraham Dondorp Arjen M Hendriksen Ilse CE Nadjm Behzad Amos Ben Mtove George Ochiai R Leon Clemens John D von Seidlein Lorenz Reyburn Hugh Deen Jacqueline |
author_sort |
Kim Deok Ryun |
title |
Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 |
title_short |
Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 |
title_full |
Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 |
title_fullStr |
Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 |
title_full_unstemmed |
Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 |
title_sort |
decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in muheza, north-eastern tanzania, 2006-2010 |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-320 https://doaj.org/article/be7f8c608f1445fca4db51aaf1dc0b9a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss 1, p 320 (2011) |
op_relation |
http://www.malariajournal.com/content/10/1/320 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-320 1475-2875 https://doaj.org/article/be7f8c608f1445fca4db51aaf1dc0b9a |
op_doi |
https://doi.org/10.1186/1475-2875-10-320 |
container_title |
Malaria Journal |
container_volume |
10 |
container_issue |
1 |
container_start_page |
320 |
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1766344416342048768 |