ESTABLISHING THE REFERENCE RANGE FOR T LYMPHOCYTES SUBPOPULATIONS IN ADULTS AND CHILDREN FROM BRAZIL

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Alex Jose Leite Torres, Ana Luiza Dias Angelo, Marcio Oliveira Silva, Milena de Carvalho Bastos, Denise Ferreira de Souza, Lilian Amaral Inocencio, Jose Alexandre Rodrigues de Lemos, Ruy S. Junior, Andrea Cauduro de Castro, Patricia Vianna Bonnini Palma, Loredana Ceci, Eduardo Martins Netto, Carlos Brites
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2013
• Subjects: CD4; CD8; Blood donors; Reference values; Brazil; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46652013000500005; https://doaj.org/article/be67ea134d904f8aa067b89111f61fbb

SUMMARY In Brazil, the existing reference values for T-lymphocytes subsets are based on data originated in other countries. There is no local information on normal variation for these parameters in Brazilian adults and children. We evaluated the normal variation found in blood donors from five large Brazilian cities, in different regions, and in children living in Salvador, and Rio de Janeiro. All samples were processed by flow cytometry. The results were analyzed according to region, gender, and lifestyle of blood donors. A total of 641 adults (63% males), and 280 children (58% males) were involved in the study. The absolute CD3+, and CD4+ cells count were significantly higher for females (adults and children). Higher CD4+ cell count in adults was associated with smoking, while higher CD8+ count was found among female children. Higher counts, for all T-cells subsets, were detected in blood donors from southeast / south regions while those living in the northern region had the lowest values. Individuals from midwestern and northeastern regions had an intermediate count for all these cells subsets. However, these differences did not reach statistical significance. In Brazil, gender and smoking, were the main determinants of differences in T-lymphocytes reference values.