Isoliensinine from Cissampelos pariera rhizomes exhibits potential gametocytocidal and anti-malarial activities against Plasmodium falciparum clinical isolates

• Published in: Malaria Journal
• Main Authors: Jackson M. Muema, James M. Mutunga, Meshack A. Obonyo, Merid N. Getahun, Ramadhan S. Mwakubambanya, Hoseah M. Akala, Agnes C. Cheruiyot, Redemptah A. Yeda, Dennis W. Juma, Ben Andagalu, Jaree L. Johnson, Amanda L. Roth, Joel L. Bargul
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2023
• Subjects: Isoliensinine; Gametocytes; Plasmodium transmission-blocking; Cissampelos pariera; Malaria control; Natural product; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Gam
• Online Access: https://doi.org/10.1186/s12936-023-04590-7; https://doaj.org/article/be6482cc39094cfb87687c85f9ebef5d

Abstract Background The unmet demand for effective malaria transmission-blocking agents targeting the transmissible stages of Plasmodium necessitates intensive discovery efforts. In this study, a bioactive bisbenzylisoquinoline (BBIQ), isoliensinine, from Cissampelos pariera (Menispermaceae) rhizome...