The Impact of Antarctic Ice Microalgae Polysaccharides on D-Galactose-Induced Oxidative Damage in Mice
Antarctic ice microalgae (Chlamydomonas sp.) are a polysaccharide-rich natural marine resource. In this study, we evaluated the impact of Antarctic ice microalgae polysaccharides (AIMP) on D-galactose-induced oxidation in mice. We conducted biological and biochemical tests on tissue and serum sample...
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ftdoajarticles:oai:doaj.org/article:be35f613be694d9584b9c34e0d8ffeb3 2023-05-15T13:54:34+02:00 The Impact of Antarctic Ice Microalgae Polysaccharides on D-Galactose-Induced Oxidative Damage in Mice Ruokun Yi Lei Deng Jianfei Mu Chong Li Fang Tan Xin Zhao 2021-03-01T00:00:00Z https://doi.org/10.3389/fnut.2021.651088 https://doaj.org/article/be35f613be694d9584b9c34e0d8ffeb3 EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fnut.2021.651088/full https://doaj.org/toc/2296-861X 2296-861X doi:10.3389/fnut.2021.651088 https://doaj.org/article/be35f613be694d9584b9c34e0d8ffeb3 Frontiers in Nutrition, Vol 8 (2021) Antarctic ice microalgae polysaccharide D-galactose oxidative damage mice Nutrition. Foods and food supply TX341-641 article 2021 ftdoajarticles https://doi.org/10.3389/fnut.2021.651088 2022-12-31T15:33:52Z Antarctic ice microalgae (Chlamydomonas sp.) are a polysaccharide-rich natural marine resource. In this study, we evaluated the impact of Antarctic ice microalgae polysaccharides (AIMP) on D-galactose-induced oxidation in mice. We conducted biological and biochemical tests on tissue and serum samples from mice treated with AIMP. We found that AIMP administration was associated with improved thymus, brain, heart, liver, spleen, and kidney index values. We also found that AIMP treatment inhibited the reduced aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, superoxide dismutase, glutathione peroxidase, and glutathione levels as well as the increased serum, splenic, and hepatic nitric oxide and malondialdehyde levels arising from oxidation in these animals. Pathological examination revealed that AIMP also inhibited D-galactose-induced oxidative damage to the spleen, liver, and skin of these animals. AIMP was additionally found to promote the upregulation of neuronal nitric oxide synthase, endothelial nitric oxide synthase, cuprozinc-superoxide dismutase, manganese superoxide dismutase, catalase, heme oxygenase-1, nuclear factor erythroid 2-related factor 2, γ-glutamylcysteine synthetase, and NAD(P)H dehydrogenase [quinone] 1 as well as the downregulation of inducible nitric oxide synthase in these animals. High-performance liquid chromatography analysis revealed AIMP to be composed of five monosaccharides (mannitol, ribose, anhydrous glucose, xylose, and fucose). Together, these results suggest that AIMP can effectively inhibit oxidative damage more readily than vitamin C in mice with D-galactose-induced oxidative damage, which underscores the value of developing AIMP derivatives for food purposes. Article in Journal/Newspaper Antarc* Antarctic Directory of Open Access Journals: DOAJ Articles Antarctic Frontiers in Nutrition 8 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
Antarctic ice microalgae polysaccharide D-galactose oxidative damage mice Nutrition. Foods and food supply TX341-641 |
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Antarctic ice microalgae polysaccharide D-galactose oxidative damage mice Nutrition. Foods and food supply TX341-641 Ruokun Yi Lei Deng Jianfei Mu Chong Li Fang Tan Xin Zhao The Impact of Antarctic Ice Microalgae Polysaccharides on D-Galactose-Induced Oxidative Damage in Mice |
topic_facet |
Antarctic ice microalgae polysaccharide D-galactose oxidative damage mice Nutrition. Foods and food supply TX341-641 |
description |
Antarctic ice microalgae (Chlamydomonas sp.) are a polysaccharide-rich natural marine resource. In this study, we evaluated the impact of Antarctic ice microalgae polysaccharides (AIMP) on D-galactose-induced oxidation in mice. We conducted biological and biochemical tests on tissue and serum samples from mice treated with AIMP. We found that AIMP administration was associated with improved thymus, brain, heart, liver, spleen, and kidney index values. We also found that AIMP treatment inhibited the reduced aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, superoxide dismutase, glutathione peroxidase, and glutathione levels as well as the increased serum, splenic, and hepatic nitric oxide and malondialdehyde levels arising from oxidation in these animals. Pathological examination revealed that AIMP also inhibited D-galactose-induced oxidative damage to the spleen, liver, and skin of these animals. AIMP was additionally found to promote the upregulation of neuronal nitric oxide synthase, endothelial nitric oxide synthase, cuprozinc-superoxide dismutase, manganese superoxide dismutase, catalase, heme oxygenase-1, nuclear factor erythroid 2-related factor 2, γ-glutamylcysteine synthetase, and NAD(P)H dehydrogenase [quinone] 1 as well as the downregulation of inducible nitric oxide synthase in these animals. High-performance liquid chromatography analysis revealed AIMP to be composed of five monosaccharides (mannitol, ribose, anhydrous glucose, xylose, and fucose). Together, these results suggest that AIMP can effectively inhibit oxidative damage more readily than vitamin C in mice with D-galactose-induced oxidative damage, which underscores the value of developing AIMP derivatives for food purposes. |
format |
Article in Journal/Newspaper |
author |
Ruokun Yi Lei Deng Jianfei Mu Chong Li Fang Tan Xin Zhao |
author_facet |
Ruokun Yi Lei Deng Jianfei Mu Chong Li Fang Tan Xin Zhao |
author_sort |
Ruokun Yi |
title |
The Impact of Antarctic Ice Microalgae Polysaccharides on D-Galactose-Induced Oxidative Damage in Mice |
title_short |
The Impact of Antarctic Ice Microalgae Polysaccharides on D-Galactose-Induced Oxidative Damage in Mice |
title_full |
The Impact of Antarctic Ice Microalgae Polysaccharides on D-Galactose-Induced Oxidative Damage in Mice |
title_fullStr |
The Impact of Antarctic Ice Microalgae Polysaccharides on D-Galactose-Induced Oxidative Damage in Mice |
title_full_unstemmed |
The Impact of Antarctic Ice Microalgae Polysaccharides on D-Galactose-Induced Oxidative Damage in Mice |
title_sort |
impact of antarctic ice microalgae polysaccharides on d-galactose-induced oxidative damage in mice |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doi.org/10.3389/fnut.2021.651088 https://doaj.org/article/be35f613be694d9584b9c34e0d8ffeb3 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Frontiers in Nutrition, Vol 8 (2021) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fnut.2021.651088/full https://doaj.org/toc/2296-861X 2296-861X doi:10.3389/fnut.2021.651088 https://doaj.org/article/be35f613be694d9584b9c34e0d8ffeb3 |
op_doi |
https://doi.org/10.3389/fnut.2021.651088 |
container_title |
Frontiers in Nutrition |
container_volume |
8 |
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1766260564979351552 |