Is International Travel an Emerging Issue on Transmission of Beijing Lineage Mycobacterium tuberculosis?
Mycobacterium tuberculosis belonging to Beijing sublineage (BL) is associated with high tuberculosis (TB) transmission, multidrug resistance, and adverse treatment outcomes. Sri Lanka experiences an increase in the number of travellers/workers to and from high TB-burden countries, and there is risk...
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ftdoajarticles:oai:doaj.org/article:bdeb9f20532c43d8a8a515327ba51886 2024-09-09T19:27:48+00:00 Is International Travel an Emerging Issue on Transmission of Beijing Lineage Mycobacterium tuberculosis? Pavithra S. Madamarandawala Srinath Satyanarayana Collins Timire Aashifa Yaqoob Dushantha Madegedara Dhammika N. Magana-Arachchi 2020-01-01T00:00:00Z https://doi.org/10.1155/2020/9357426 https://doaj.org/article/bdeb9f20532c43d8a8a515327ba51886 EN eng Wiley http://dx.doi.org/10.1155/2020/9357426 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2020/9357426 https://doaj.org/article/bdeb9f20532c43d8a8a515327ba51886 Journal of Tropical Medicine, Vol 2020 (2020) Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.1155/2020/9357426 2024-08-05T17:48:47Z Mycobacterium tuberculosis belonging to Beijing sublineage (BL) is associated with high tuberculosis (TB) transmission, multidrug resistance, and adverse treatment outcomes. Sri Lanka experiences an increase in the number of travellers/workers to and from high TB-burden countries, and there is risk of getting BL strains imported into the country. In this context, a cohort study was conducted to assess the prevalence of BL strains among pulmonary tuberculosis (PTB) patients in the Kandy district of Sri Lanka (a popular tourist destination) and its association with patients’ sociodemographic and clinical characteristics. The study population included sputum smear-positive PTB patients diagnosed from February 2018–July 2019. Fresh sputum samples were collected for culturing and conducted polymerase chain reaction using BL-specific primers. Among the 101 patients recruited, presence of BL strains could be ascertained in 94 patients of which 24 (26%; 95% CI: 18%–35%) had BL strains. Prevalence of BL strains was higher among those with high sputum smear grades (2+ and 3+) (P<0.05) and those who had travelled abroad (P<0.05). The prevalence was also higher among young people (aged <35 years). Treatment success rates were similar in patients with (83%) and without BL strains (83% vs. 81%; P value = 0.8375). The prevalence of BL strains in Kandy, Sri Lanka, was high compared to previously reported figures in Sri Lanka, and the percentage drives closer to the countries in South East Asia. International travel raises itself as an emerging issue in BL transmission urging the need of policies and practices in immigration/emigration strategies. The study findings have the potential to alter the TB epidemiology in the country and might represent the situation in other underexplored countries as well. Therefore, it is important to monitor the trends and factors related to the prevalence of Beijing strains globally and make decisions as a whole. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2020 1 8 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Pavithra S. Madamarandawala Srinath Satyanarayana Collins Timire Aashifa Yaqoob Dushantha Madegedara Dhammika N. Magana-Arachchi Is International Travel an Emerging Issue on Transmission of Beijing Lineage Mycobacterium tuberculosis? |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Mycobacterium tuberculosis belonging to Beijing sublineage (BL) is associated with high tuberculosis (TB) transmission, multidrug resistance, and adverse treatment outcomes. Sri Lanka experiences an increase in the number of travellers/workers to and from high TB-burden countries, and there is risk of getting BL strains imported into the country. In this context, a cohort study was conducted to assess the prevalence of BL strains among pulmonary tuberculosis (PTB) patients in the Kandy district of Sri Lanka (a popular tourist destination) and its association with patients’ sociodemographic and clinical characteristics. The study population included sputum smear-positive PTB patients diagnosed from February 2018–July 2019. Fresh sputum samples were collected for culturing and conducted polymerase chain reaction using BL-specific primers. Among the 101 patients recruited, presence of BL strains could be ascertained in 94 patients of which 24 (26%; 95% CI: 18%–35%) had BL strains. Prevalence of BL strains was higher among those with high sputum smear grades (2+ and 3+) (P<0.05) and those who had travelled abroad (P<0.05). The prevalence was also higher among young people (aged <35 years). Treatment success rates were similar in patients with (83%) and without BL strains (83% vs. 81%; P value = 0.8375). The prevalence of BL strains in Kandy, Sri Lanka, was high compared to previously reported figures in Sri Lanka, and the percentage drives closer to the countries in South East Asia. International travel raises itself as an emerging issue in BL transmission urging the need of policies and practices in immigration/emigration strategies. The study findings have the potential to alter the TB epidemiology in the country and might represent the situation in other underexplored countries as well. Therefore, it is important to monitor the trends and factors related to the prevalence of Beijing strains globally and make decisions as a whole. |
format |
Article in Journal/Newspaper |
author |
Pavithra S. Madamarandawala Srinath Satyanarayana Collins Timire Aashifa Yaqoob Dushantha Madegedara Dhammika N. Magana-Arachchi |
author_facet |
Pavithra S. Madamarandawala Srinath Satyanarayana Collins Timire Aashifa Yaqoob Dushantha Madegedara Dhammika N. Magana-Arachchi |
author_sort |
Pavithra S. Madamarandawala |
title |
Is International Travel an Emerging Issue on Transmission of Beijing Lineage Mycobacterium tuberculosis? |
title_short |
Is International Travel an Emerging Issue on Transmission of Beijing Lineage Mycobacterium tuberculosis? |
title_full |
Is International Travel an Emerging Issue on Transmission of Beijing Lineage Mycobacterium tuberculosis? |
title_fullStr |
Is International Travel an Emerging Issue on Transmission of Beijing Lineage Mycobacterium tuberculosis? |
title_full_unstemmed |
Is International Travel an Emerging Issue on Transmission of Beijing Lineage Mycobacterium tuberculosis? |
title_sort |
is international travel an emerging issue on transmission of beijing lineage mycobacterium tuberculosis? |
publisher |
Wiley |
publishDate |
2020 |
url |
https://doi.org/10.1155/2020/9357426 https://doaj.org/article/bdeb9f20532c43d8a8a515327ba51886 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2020 (2020) |
op_relation |
http://dx.doi.org/10.1155/2020/9357426 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2020/9357426 https://doaj.org/article/bdeb9f20532c43d8a8a515327ba51886 |
op_doi |
https://doi.org/10.1155/2020/9357426 |
container_title |
Journal of Tropical Medicine |
container_volume |
2020 |
container_start_page |
1 |
op_container_end_page |
8 |
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1809897155935076352 |