Human plague: An old scourge that needs new answers.
Yersinia pestis, the bacterial causative agent of plague, remains an important threat to human health. Plague is a rodent-borne disease that has historically shown an outstanding ability to colonize and persist across different species, habitats, and environments while provoking sporadic cases, outb...
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ftdoajarticles:oai:doaj.org/article:bdbfbe68856044758e6794fdc5a8d128 2023-05-15T15:09:46+02:00 Human plague: An old scourge that needs new answers. Xavier Vallès Nils Chr Stenseth Christian Demeure Peter Horby Paul S Mead Oswaldo Cabanillas Mahery Ratsitorahina Minoarisoa Rajerison Voahangy Andrianaivoarimanana Beza Ramasindrazana Javier Pizarro-Cerda Holger C Scholz Romain Girod B Joseph Hinnebusch Ines Vigan-Womas Arnaud Fontanet David M Wagner Sandra Telfer Yazdan Yazdanpanah Pablo Tortosa Guia Carrara Jane Deuve Steven R Belmain Eric D'Ortenzio Laurence Baril 2020-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008251 https://doaj.org/article/bdbfbe68856044758e6794fdc5a8d128 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008251 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008251 https://doaj.org/article/bdbfbe68856044758e6794fdc5a8d128 PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008251 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008251 2022-12-31T11:55:03Z Yersinia pestis, the bacterial causative agent of plague, remains an important threat to human health. Plague is a rodent-borne disease that has historically shown an outstanding ability to colonize and persist across different species, habitats, and environments while provoking sporadic cases, outbreaks, and deadly global epidemics among humans. Between September and November 2017, an outbreak of urban pneumonic plague was declared in Madagascar, which refocused the attention of the scientific community on this ancient human scourge. Given recent trends and plague's resilience to control in the wild, its high fatality rate in humans without early treatment, and its capacity to disrupt social and healthcare systems, human plague should be considered as a neglected threat. A workshop was held in Paris in July 2018 to review current knowledge about plague and to identify the scientific research priorities to eradicate plague as a human threat. It was concluded that an urgent commitment is needed to develop and fund a strong research agenda aiming to fill the current knowledge gaps structured around 4 main axes: (i) an improved understanding of the ecological interactions among the reservoir, vector, pathogen, and environment; (ii) human and societal responses; (iii) improved diagnostic tools and case management; and (iv) vaccine development. These axes should be cross-cutting, translational, and focused on delivering context-specific strategies. Results of this research should feed a global control and prevention strategy within a "One Health" approach. Article in Journal/Newspaper Arctic Human health Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 8 e0008251 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Xavier Vallès Nils Chr Stenseth Christian Demeure Peter Horby Paul S Mead Oswaldo Cabanillas Mahery Ratsitorahina Minoarisoa Rajerison Voahangy Andrianaivoarimanana Beza Ramasindrazana Javier Pizarro-Cerda Holger C Scholz Romain Girod B Joseph Hinnebusch Ines Vigan-Womas Arnaud Fontanet David M Wagner Sandra Telfer Yazdan Yazdanpanah Pablo Tortosa Guia Carrara Jane Deuve Steven R Belmain Eric D'Ortenzio Laurence Baril Human plague: An old scourge that needs new answers. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Yersinia pestis, the bacterial causative agent of plague, remains an important threat to human health. Plague is a rodent-borne disease that has historically shown an outstanding ability to colonize and persist across different species, habitats, and environments while provoking sporadic cases, outbreaks, and deadly global epidemics among humans. Between September and November 2017, an outbreak of urban pneumonic plague was declared in Madagascar, which refocused the attention of the scientific community on this ancient human scourge. Given recent trends and plague's resilience to control in the wild, its high fatality rate in humans without early treatment, and its capacity to disrupt social and healthcare systems, human plague should be considered as a neglected threat. A workshop was held in Paris in July 2018 to review current knowledge about plague and to identify the scientific research priorities to eradicate plague as a human threat. It was concluded that an urgent commitment is needed to develop and fund a strong research agenda aiming to fill the current knowledge gaps structured around 4 main axes: (i) an improved understanding of the ecological interactions among the reservoir, vector, pathogen, and environment; (ii) human and societal responses; (iii) improved diagnostic tools and case management; and (iv) vaccine development. These axes should be cross-cutting, translational, and focused on delivering context-specific strategies. Results of this research should feed a global control and prevention strategy within a "One Health" approach. |
format |
Article in Journal/Newspaper |
author |
Xavier Vallès Nils Chr Stenseth Christian Demeure Peter Horby Paul S Mead Oswaldo Cabanillas Mahery Ratsitorahina Minoarisoa Rajerison Voahangy Andrianaivoarimanana Beza Ramasindrazana Javier Pizarro-Cerda Holger C Scholz Romain Girod B Joseph Hinnebusch Ines Vigan-Womas Arnaud Fontanet David M Wagner Sandra Telfer Yazdan Yazdanpanah Pablo Tortosa Guia Carrara Jane Deuve Steven R Belmain Eric D'Ortenzio Laurence Baril |
author_facet |
Xavier Vallès Nils Chr Stenseth Christian Demeure Peter Horby Paul S Mead Oswaldo Cabanillas Mahery Ratsitorahina Minoarisoa Rajerison Voahangy Andrianaivoarimanana Beza Ramasindrazana Javier Pizarro-Cerda Holger C Scholz Romain Girod B Joseph Hinnebusch Ines Vigan-Womas Arnaud Fontanet David M Wagner Sandra Telfer Yazdan Yazdanpanah Pablo Tortosa Guia Carrara Jane Deuve Steven R Belmain Eric D'Ortenzio Laurence Baril |
author_sort |
Xavier Vallès |
title |
Human plague: An old scourge that needs new answers. |
title_short |
Human plague: An old scourge that needs new answers. |
title_full |
Human plague: An old scourge that needs new answers. |
title_fullStr |
Human plague: An old scourge that needs new answers. |
title_full_unstemmed |
Human plague: An old scourge that needs new answers. |
title_sort |
human plague: an old scourge that needs new answers. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008251 https://doaj.org/article/bdbfbe68856044758e6794fdc5a8d128 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Human health |
genre_facet |
Arctic Human health |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008251 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008251 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008251 https://doaj.org/article/bdbfbe68856044758e6794fdc5a8d128 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008251 |
container_title |
PLOS Neglected Tropical Diseases |
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14 |
container_issue |
8 |
container_start_page |
e0008251 |
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1766340886910730240 |