Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Chewaka District, Ethiopia
Abstract Background The efficacy of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum malaria in south-western Ethiopia is poorly documented. Regular monitoring of drug efficacy is an important tool for supporting national treatment policies and practice. This study i...
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ftdoajarticles:oai:doaj.org/article:bdb1e1f83afe4b06817ddc16df18c3b1 2023-05-15T15:18:37+02:00 Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Chewaka District, Ethiopia Abdulhakim Abamecha Daniel Yilma Wondimagegn Addisu Hassan El-Abid Achim Ibenthal Harald Noedl Delenasaw Yewhalaw Mohieddine Moumni Alemseged Abdissa 2020-07-01T00:00:00Z https://doi.org/10.1186/s12936-020-03307-4 https://doaj.org/article/bdb1e1f83afe4b06817ddc16df18c3b1 EN eng BMC http://link.springer.com/article/10.1186/s12936-020-03307-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03307-4 1475-2875 https://doaj.org/article/bdb1e1f83afe4b06817ddc16df18c3b1 Malaria Journal, Vol 19, Iss 1, Pp 1-10 (2020) Therapeutic efficacy Artemether-lumefantrine Uncomplicated malaria Ethiopia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-03307-4 2022-12-31T15:45:39Z Abstract Background The efficacy of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum malaria in south-western Ethiopia is poorly documented. Regular monitoring of drug efficacy is an important tool for supporting national treatment policies and practice. This study investigated the therapeutic efficacy of AL for the treatment of P. falciparum malaria in Ethiopia. Methods The study was a one-arm, prospective, evaluation of the clinical and parasitological, responses to directly observed treatment with AL among participants 6 months and older with uncomplicated P. falciparum malaria. Real-time polymerase chain reaction (PCR) and nested PCR reaction methods were used to quantify and genotype P. falciparum. A modified protocol based on the World Health Organization 2009 recommendations for the surveillance of anti-malarial drug efficacy was used for the study with primary outcomes, clinical and parasitological cure rates at day-28. Secondary outcomes assessed included patterns of fever and parasite clearance. Cure rate on day-28 was assessed by intention to treat (ITT) and per protocol (PP) analysis. Parasite genotyping was also performed at baseline and at the time of recurrence of parasitaemia to differentiate between recrudescence and new infection. Results Of the 80 study participants enrolled, 75 completed the follow-up at day-28 with ACPR. For per protocol (PP) analysis, PCR-uncorrected and-corrected cure rate of AL among the study participants was 94.7% (95% CI 87.1–98.5) and 96% (95% CI 88.8–99.2), respectively. For intention to treat (ITT) analysis, the cure rate was 90% (95% CI 88.8–99.2). Based on Kaplan–Meier survival estimate, the cumulative incidence of failure rate of AL was 3.8% (95% CI 1.3–11.4). Only three participants 3.8% (95% CI 0.8–10.6) of the 80 enrolled participants were found to be positive on day-3. The day three-positive participants were followed up to day 28 and did not correspond to treatment failures observed during follow-up. Only 7.5% (6/80) of the ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Meier ENVELOPE(-45.900,-45.900,-60.633,-60.633) Malaria Journal 19 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Therapeutic efficacy Artemether-lumefantrine Uncomplicated malaria Ethiopia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Therapeutic efficacy Artemether-lumefantrine Uncomplicated malaria Ethiopia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Abdulhakim Abamecha Daniel Yilma Wondimagegn Addisu Hassan El-Abid Achim Ibenthal Harald Noedl Delenasaw Yewhalaw Mohieddine Moumni Alemseged Abdissa Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Chewaka District, Ethiopia |
topic_facet |
Therapeutic efficacy Artemether-lumefantrine Uncomplicated malaria Ethiopia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The efficacy of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum malaria in south-western Ethiopia is poorly documented. Regular monitoring of drug efficacy is an important tool for supporting national treatment policies and practice. This study investigated the therapeutic efficacy of AL for the treatment of P. falciparum malaria in Ethiopia. Methods The study was a one-arm, prospective, evaluation of the clinical and parasitological, responses to directly observed treatment with AL among participants 6 months and older with uncomplicated P. falciparum malaria. Real-time polymerase chain reaction (PCR) and nested PCR reaction methods were used to quantify and genotype P. falciparum. A modified protocol based on the World Health Organization 2009 recommendations for the surveillance of anti-malarial drug efficacy was used for the study with primary outcomes, clinical and parasitological cure rates at day-28. Secondary outcomes assessed included patterns of fever and parasite clearance. Cure rate on day-28 was assessed by intention to treat (ITT) and per protocol (PP) analysis. Parasite genotyping was also performed at baseline and at the time of recurrence of parasitaemia to differentiate between recrudescence and new infection. Results Of the 80 study participants enrolled, 75 completed the follow-up at day-28 with ACPR. For per protocol (PP) analysis, PCR-uncorrected and-corrected cure rate of AL among the study participants was 94.7% (95% CI 87.1–98.5) and 96% (95% CI 88.8–99.2), respectively. For intention to treat (ITT) analysis, the cure rate was 90% (95% CI 88.8–99.2). Based on Kaplan–Meier survival estimate, the cumulative incidence of failure rate of AL was 3.8% (95% CI 1.3–11.4). Only three participants 3.8% (95% CI 0.8–10.6) of the 80 enrolled participants were found to be positive on day-3. The day three-positive participants were followed up to day 28 and did not correspond to treatment failures observed during follow-up. Only 7.5% (6/80) of the ... |
format |
Article in Journal/Newspaper |
author |
Abdulhakim Abamecha Daniel Yilma Wondimagegn Addisu Hassan El-Abid Achim Ibenthal Harald Noedl Delenasaw Yewhalaw Mohieddine Moumni Alemseged Abdissa |
author_facet |
Abdulhakim Abamecha Daniel Yilma Wondimagegn Addisu Hassan El-Abid Achim Ibenthal Harald Noedl Delenasaw Yewhalaw Mohieddine Moumni Alemseged Abdissa |
author_sort |
Abdulhakim Abamecha |
title |
Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Chewaka District, Ethiopia |
title_short |
Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Chewaka District, Ethiopia |
title_full |
Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Chewaka District, Ethiopia |
title_fullStr |
Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Chewaka District, Ethiopia |
title_full_unstemmed |
Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Chewaka District, Ethiopia |
title_sort |
therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated plasmodium falciparum malaria in chewaka district, ethiopia |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-03307-4 https://doaj.org/article/bdb1e1f83afe4b06817ddc16df18c3b1 |
long_lat |
ENVELOPE(-45.900,-45.900,-60.633,-60.633) |
geographic |
Arctic Meier |
geographic_facet |
Arctic Meier |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-10 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s12936-020-03307-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03307-4 1475-2875 https://doaj.org/article/bdb1e1f83afe4b06817ddc16df18c3b1 |
op_doi |
https://doi.org/10.1186/s12936-020-03307-4 |
container_title |
Malaria Journal |
container_volume |
19 |
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1 |
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1766348813454278656 |