Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case Febre amarela silvestre: estudo clínico e laboratorial, enfatizando a viremia, de um caso humano

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Elza da S. Nassar, Esther L. B. Chamelet, Terezinha L. M. Coimbra, Luiza T. M. de Souza, Akemi Suzuki, Ivani B. Ferreira, Marcos V. da Silva, Iray M. Rocco, Amélia P. A. Travassos da Rosa
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1995
• Subjects: Arbovirus; Jungle yellow fever; Viremia; Clinical and laboratorial diagnosis; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Sob’
• Online Access: https://doi.org/10.1590/S0036-46651995000400009; https://doaj.org/article/bd8c467931e244c38f44d93655fed582

The authors report the clinical, laboratorial and epidemiological aspects of a human case of jungle yellow fever. The patient suffered from fever, chills, sweating, headaches, backaches, myalgia, epigastric pains, nausea, vomiting, diarrhea and prostration. He was unvaccinated and had been working in areas where cases of jungle yellow fever had been confirmed. Investigations concerning the yellow fever virus were performed. Blood samples were collected on several days in the course of the illness. Three of these samples (those obtained on days 5,7 and 10) were inoculated into suckling mice in attempt to isolate virus and to titrate the viremia level. Serological surveys were carried out by using the IgM Antibodies Capture Enzyme Linked Immunosorbent Assay (MAC-ELISA), Complement Fixation (CF), Hemagglulinalion Inhibition (HI) and Neutralization (N) tests. The yellow fever virus, recovered from the two first samples and the virus titration, showed high level of viremia. After that, specific antibodies appeared in all samples. The interval between the end of the viremia and the appearance of the antibodies was associated with the worsening of clinical symptoms, including bleeding of the mucous membrane. One must be aware of the risk of having a urban epidemics in areas where Aedes aegypti is found in high infestation indexes. Os autores estudaram um caso humano de febre amarela silvestre, sob os aspectos clínico, laboratorial e epidemiológico. O paciente apresentava febre (39ºC), calafrios, sudorese, cefaléia, dor lombar, mialgia, dor abdominal em epigástrio, náuseas, vômitos, diarréia e prostração. Relatava permanência em área onde foram constatados casos de febre amarela silvestre e não havia histórico de vacinação anterior. Frente às suspeitas que levaram à investigação do vírus da febre amarela, foram colhidas várias amostras de sangue no curso da doença. As amostras do 5º, 7º e 10º dias foram submetidas a provas de isolamento e quantificação do vírus, o que possibilitou o estudo da viremia. Empregando-se os ...