Fecal carriage and factors associated with extended-spectrum β-lactamase-producing Enterobacteriaceae among pregnant women at the tertiary referral hospital, Tanzania
Abstract Background Infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are increasing worldwide. Evidence indicates that fecal carriage of ESBL-E in pregnancy predisposes women to potential life-threatening urinary tract infections and subsequently increasing the r...
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ftdoajarticles:oai:doaj.org/article:bd800c3b26ec4b78b4349887cd013769 2023-05-15T15:14:19+02:00 Fecal carriage and factors associated with extended-spectrum β-lactamase-producing Enterobacteriaceae among pregnant women at the tertiary referral hospital, Tanzania Ambele M. Mwandigha Doreen Kamori Upendo O. Kibwana Salim Masoud Joel Manyahi Mtebe Majigo 2020-10-01T00:00:00Z https://doi.org/10.1186/s41182-020-00271-2 https://doaj.org/article/bd800c3b26ec4b78b4349887cd013769 EN eng BMC http://link.springer.com/article/10.1186/s41182-020-00271-2 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-020-00271-2 1349-4147 https://doaj.org/article/bd800c3b26ec4b78b4349887cd013769 Tropical Medicine and Health, Vol 48, Iss 1, Pp 1-8 (2020) Extended-spectrum beta-lactamase Enterobacteriaceae Fecal carriage Antimicrobial resistance Pregnancy Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.1186/s41182-020-00271-2 2022-12-31T09:50:50Z Abstract Background Infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are increasing worldwide. Evidence indicates that fecal carriage of ESBL-E in pregnancy predisposes women to potential life-threatening urinary tract infections and subsequently increasing the risk of neonatal infections. There is limited data regarding fecal carriage of ESBL-E and associated factors among pregnant women in Tanzania. We aimed to address the gap by determining the proportion of pregnant women with ESBL-E fecal carriage and identify the related factors. Methodology A hospital-based cross-sectional study was conducted at Muhimbili National Hospital in Dar es Salaam, Tanzania. A total of 182 pregnant women at the gestational age of 37 weeks and above were enrolled. Participants’ socio-demographic, clinical, and hygienic information were collected by using a well-structured questionnaire. Rectal swabs were collected and processed for isolation of ESBL-E. The extended-spectrum β-lactamase production and antibiotic susceptibility test (AST) were performed using a double-disc synergy test and Kirby-Bauer disc diffusion method, respectively. Results A total of 117 (64.3%) pregnant women were found to carry ESBL-E. Factors such as self-prescription of antibiotic medication during pregnancy, low education level, and toilet sharing were independently associated with ESBL-E fecal carriage. Five ESBL-E species that were isolated include Escherichia coli (84.6%), Klebsiella pneumoniae (8.9%), Klebsiella oxytoca (3.3%), Citrobacter spp. (1.6%), and Enterobacter spp. (1.6%). ESBL-E isolates demonstrated high resistance to aztreonam and sulphamethoxazole-trimethoprim. Conclusion This study has revealed a relatively high fecal carriage of ESBL-E among pregnant women, suggesting that there is a need for routine screening among that population. We recommend further studies to explore comprehensively the factors associated with high fecal carriage of ESBL-E in pregnancy and the potential transmission kinetics to ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Tropical Medicine and Health 48 1 |
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English |
topic |
Extended-spectrum beta-lactamase Enterobacteriaceae Fecal carriage Antimicrobial resistance Pregnancy Arctic medicine. Tropical medicine RC955-962 |
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Extended-spectrum beta-lactamase Enterobacteriaceae Fecal carriage Antimicrobial resistance Pregnancy Arctic medicine. Tropical medicine RC955-962 Ambele M. Mwandigha Doreen Kamori Upendo O. Kibwana Salim Masoud Joel Manyahi Mtebe Majigo Fecal carriage and factors associated with extended-spectrum β-lactamase-producing Enterobacteriaceae among pregnant women at the tertiary referral hospital, Tanzania |
topic_facet |
Extended-spectrum beta-lactamase Enterobacteriaceae Fecal carriage Antimicrobial resistance Pregnancy Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background Infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are increasing worldwide. Evidence indicates that fecal carriage of ESBL-E in pregnancy predisposes women to potential life-threatening urinary tract infections and subsequently increasing the risk of neonatal infections. There is limited data regarding fecal carriage of ESBL-E and associated factors among pregnant women in Tanzania. We aimed to address the gap by determining the proportion of pregnant women with ESBL-E fecal carriage and identify the related factors. Methodology A hospital-based cross-sectional study was conducted at Muhimbili National Hospital in Dar es Salaam, Tanzania. A total of 182 pregnant women at the gestational age of 37 weeks and above were enrolled. Participants’ socio-demographic, clinical, and hygienic information were collected by using a well-structured questionnaire. Rectal swabs were collected and processed for isolation of ESBL-E. The extended-spectrum β-lactamase production and antibiotic susceptibility test (AST) were performed using a double-disc synergy test and Kirby-Bauer disc diffusion method, respectively. Results A total of 117 (64.3%) pregnant women were found to carry ESBL-E. Factors such as self-prescription of antibiotic medication during pregnancy, low education level, and toilet sharing were independently associated with ESBL-E fecal carriage. Five ESBL-E species that were isolated include Escherichia coli (84.6%), Klebsiella pneumoniae (8.9%), Klebsiella oxytoca (3.3%), Citrobacter spp. (1.6%), and Enterobacter spp. (1.6%). ESBL-E isolates demonstrated high resistance to aztreonam and sulphamethoxazole-trimethoprim. Conclusion This study has revealed a relatively high fecal carriage of ESBL-E among pregnant women, suggesting that there is a need for routine screening among that population. We recommend further studies to explore comprehensively the factors associated with high fecal carriage of ESBL-E in pregnancy and the potential transmission kinetics to ... |
format |
Article in Journal/Newspaper |
author |
Ambele M. Mwandigha Doreen Kamori Upendo O. Kibwana Salim Masoud Joel Manyahi Mtebe Majigo |
author_facet |
Ambele M. Mwandigha Doreen Kamori Upendo O. Kibwana Salim Masoud Joel Manyahi Mtebe Majigo |
author_sort |
Ambele M. Mwandigha |
title |
Fecal carriage and factors associated with extended-spectrum β-lactamase-producing Enterobacteriaceae among pregnant women at the tertiary referral hospital, Tanzania |
title_short |
Fecal carriage and factors associated with extended-spectrum β-lactamase-producing Enterobacteriaceae among pregnant women at the tertiary referral hospital, Tanzania |
title_full |
Fecal carriage and factors associated with extended-spectrum β-lactamase-producing Enterobacteriaceae among pregnant women at the tertiary referral hospital, Tanzania |
title_fullStr |
Fecal carriage and factors associated with extended-spectrum β-lactamase-producing Enterobacteriaceae among pregnant women at the tertiary referral hospital, Tanzania |
title_full_unstemmed |
Fecal carriage and factors associated with extended-spectrum β-lactamase-producing Enterobacteriaceae among pregnant women at the tertiary referral hospital, Tanzania |
title_sort |
fecal carriage and factors associated with extended-spectrum β-lactamase-producing enterobacteriaceae among pregnant women at the tertiary referral hospital, tanzania |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s41182-020-00271-2 https://doaj.org/article/bd800c3b26ec4b78b4349887cd013769 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 48, Iss 1, Pp 1-8 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s41182-020-00271-2 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-020-00271-2 1349-4147 https://doaj.org/article/bd800c3b26ec4b78b4349887cd013769 |
op_doi |
https://doi.org/10.1186/s41182-020-00271-2 |
container_title |
Tropical Medicine and Health |
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48 |
container_issue |
1 |
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1766344776543633408 |