Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas.
BACKGROUND:In low elevation arid regions throughout the southern United States, Borrelia turicatae is the principal agent of tick-borne relapsing fever. However, endemic foci and the vertebrate hosts involved in the ecology of B. turicatae remain undefined. Experimental infection studies suggest tha...
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ftdoajarticles:oai:doaj.org/article:bd731df0271e4f64bf26cc544ebc107e 2023-05-15T15:07:28+02:00 Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas. Brittany A Armstrong Alexander Kneubehl Aparna Krishnavajhala Hannah K Wilder William Boyle Edward Wozniak Carson Phillips Kristen Hollywood Kristy O Murray Taylor G Donaldson Pete D Teel Ken Waldrup Job E Lopez 2018-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006877 https://doaj.org/article/bd731df0271e4f64bf26cc544ebc107e EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6224114?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006877 https://doaj.org/article/bd731df0271e4f64bf26cc544ebc107e PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006877 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006877 2022-12-31T09:17:45Z BACKGROUND:In low elevation arid regions throughout the southern United States, Borrelia turicatae is the principal agent of tick-borne relapsing fever. However, endemic foci and the vertebrate hosts involved in the ecology of B. turicatae remain undefined. Experimental infection studies suggest that small and medium sized mammals likely maintain B. turicatae in nature, while the tick vector is a long-lived reservoir. METHODOLOGY/PRINCIPAL FINDINGS:Serum samples from wild caught rodents, raccoons, and wild and domestic canids from 23 counties in Texas were screened for prior exposure to B. turicatae. Serological assays were performed using B. turicatae protein lysates and recombinant Borrelia immunogenic protein A (rBipA), a diagnostic protein that is unique to RF spirochetes and may be a species-specific antigen. CONCLUSIONS/SIGNIFICANCE:Serological responses to B. turicatae were detected from 24 coyotes, one gray fox, two raccoons, and one rodent from six counties in Texas. These studies indicate that wild canids and raccoons were exposed to B. turicatae and are likely involved in the pathogen's ecology. Additionally, more work should focus on evaluating rodent exposure to B. turicatae and the role of these small mammals in the pathogen's maintenance in nature. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 10 e0006877 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Brittany A Armstrong Alexander Kneubehl Aparna Krishnavajhala Hannah K Wilder William Boyle Edward Wozniak Carson Phillips Kristen Hollywood Kristy O Murray Taylor G Donaldson Pete D Teel Ken Waldrup Job E Lopez Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:In low elevation arid regions throughout the southern United States, Borrelia turicatae is the principal agent of tick-borne relapsing fever. However, endemic foci and the vertebrate hosts involved in the ecology of B. turicatae remain undefined. Experimental infection studies suggest that small and medium sized mammals likely maintain B. turicatae in nature, while the tick vector is a long-lived reservoir. METHODOLOGY/PRINCIPAL FINDINGS:Serum samples from wild caught rodents, raccoons, and wild and domestic canids from 23 counties in Texas were screened for prior exposure to B. turicatae. Serological assays were performed using B. turicatae protein lysates and recombinant Borrelia immunogenic protein A (rBipA), a diagnostic protein that is unique to RF spirochetes and may be a species-specific antigen. CONCLUSIONS/SIGNIFICANCE:Serological responses to B. turicatae were detected from 24 coyotes, one gray fox, two raccoons, and one rodent from six counties in Texas. These studies indicate that wild canids and raccoons were exposed to B. turicatae and are likely involved in the pathogen's ecology. Additionally, more work should focus on evaluating rodent exposure to B. turicatae and the role of these small mammals in the pathogen's maintenance in nature. |
format |
Article in Journal/Newspaper |
author |
Brittany A Armstrong Alexander Kneubehl Aparna Krishnavajhala Hannah K Wilder William Boyle Edward Wozniak Carson Phillips Kristen Hollywood Kristy O Murray Taylor G Donaldson Pete D Teel Ken Waldrup Job E Lopez |
author_facet |
Brittany A Armstrong Alexander Kneubehl Aparna Krishnavajhala Hannah K Wilder William Boyle Edward Wozniak Carson Phillips Kristen Hollywood Kristy O Murray Taylor G Donaldson Pete D Teel Ken Waldrup Job E Lopez |
author_sort |
Brittany A Armstrong |
title |
Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas. |
title_short |
Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas. |
title_full |
Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas. |
title_fullStr |
Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas. |
title_full_unstemmed |
Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas. |
title_sort |
seroprevalence for the tick-borne relapsing fever spirochete borrelia turicatae among small and medium sized mammals of texas. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006877 https://doaj.org/article/bd731df0271e4f64bf26cc544ebc107e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006877 (2018) |
op_relation |
http://europepmc.org/articles/PMC6224114?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006877 https://doaj.org/article/bd731df0271e4f64bf26cc544ebc107e |
op_doi |
https://doi.org/10.1371/journal.pntd.0006877 |
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PLOS Neglected Tropical Diseases |
container_volume |
12 |
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10 |
container_start_page |
e0006877 |
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