Management of post-transplant Epstein-Barr virus-related lymphoproliferative disease in solid organ and hematopoietic stem cell recipients
Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disease (PTLD) is one of the most serious complications associated with solid organ and hematopoietic stem cell transplantation. PTLD is most frequently seen with primary EBV infection post-transplant, a common scenario for pediatr...
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ftdoajarticles:oai:doaj.org/article:bd4f9547bcab44f3bb886a44f594018c 2023-05-15T15:05:16+02:00 Management of post-transplant Epstein-Barr virus-related lymphoproliferative disease in solid organ and hematopoietic stem cell recipients Heloisa Helena de Sousa Marques Maria Aparecida Shikanai-Yasuda Luiz Sérgio Fonseca de Azevedo Hélio Helh Caiaffa-Filho Lígia Camera Pierrotti Maria Zilda de Aquino Marta Heloisa Lopes Natalya Zaidan Maluf Silvia Vidal Campos Silvia Figueiredo Costa 2014-10-01T00:00:00Z https://doi.org/10.1590/0037-8682-0036-2014 https://doaj.org/article/bd4f9547bcab44f3bb886a44f594018c EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000500543&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0036-2014 https://doaj.org/article/bd4f9547bcab44f3bb886a44f594018c Revista da Sociedade Brasileira de Medicina Tropical, Vol 47, Iss 5, Pp 543-546 (2014) Epstein-Barr virus Lymphoproliferative disorders Transplantation Diagnosis Combined modality therapy Arctic medicine. Tropical medicine RC955-962 article 2014 ftdoajarticles https://doi.org/10.1590/0037-8682-0036-2014 2022-12-31T02:41:37Z Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disease (PTLD) is one of the most serious complications associated with solid organ and hematopoietic stem cell transplantation. PTLD is most frequently seen with primary EBV infection post-transplant, a common scenario for pediatric solid organ recipients. Risk factors for infection or reactivation of EBV following solid organ transplant are stronger immunosuppressive therapy regimens, and being seronegative for receptor. For hematopoietic stem cell transplantation, the risk factors relate to the type of transplant, human leukocyte antigen disparity, the use of stronger immunosuppressants, T-cell depletion, and severe graft-versus-host disease. Mortality is high, and most frequent in patients who develop PTLD in the first six months post-transplant. The primary goal of this article is to provide an overview of the clinical manifestations, diagnosis, accepted therapies, and management of EBV infection in transplant recipients, and to suggest that the adoption of monitoring protocols could contribute to a reduction in related complications. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 47 5 543 546 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Epstein-Barr virus Lymphoproliferative disorders Transplantation Diagnosis Combined modality therapy Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Epstein-Barr virus Lymphoproliferative disorders Transplantation Diagnosis Combined modality therapy Arctic medicine. Tropical medicine RC955-962 Heloisa Helena de Sousa Marques Maria Aparecida Shikanai-Yasuda Luiz Sérgio Fonseca de Azevedo Hélio Helh Caiaffa-Filho Lígia Camera Pierrotti Maria Zilda de Aquino Marta Heloisa Lopes Natalya Zaidan Maluf Silvia Vidal Campos Silvia Figueiredo Costa Management of post-transplant Epstein-Barr virus-related lymphoproliferative disease in solid organ and hematopoietic stem cell recipients |
topic_facet |
Epstein-Barr virus Lymphoproliferative disorders Transplantation Diagnosis Combined modality therapy Arctic medicine. Tropical medicine RC955-962 |
description |
Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disease (PTLD) is one of the most serious complications associated with solid organ and hematopoietic stem cell transplantation. PTLD is most frequently seen with primary EBV infection post-transplant, a common scenario for pediatric solid organ recipients. Risk factors for infection or reactivation of EBV following solid organ transplant are stronger immunosuppressive therapy regimens, and being seronegative for receptor. For hematopoietic stem cell transplantation, the risk factors relate to the type of transplant, human leukocyte antigen disparity, the use of stronger immunosuppressants, T-cell depletion, and severe graft-versus-host disease. Mortality is high, and most frequent in patients who develop PTLD in the first six months post-transplant. The primary goal of this article is to provide an overview of the clinical manifestations, diagnosis, accepted therapies, and management of EBV infection in transplant recipients, and to suggest that the adoption of monitoring protocols could contribute to a reduction in related complications. |
format |
Article in Journal/Newspaper |
author |
Heloisa Helena de Sousa Marques Maria Aparecida Shikanai-Yasuda Luiz Sérgio Fonseca de Azevedo Hélio Helh Caiaffa-Filho Lígia Camera Pierrotti Maria Zilda de Aquino Marta Heloisa Lopes Natalya Zaidan Maluf Silvia Vidal Campos Silvia Figueiredo Costa |
author_facet |
Heloisa Helena de Sousa Marques Maria Aparecida Shikanai-Yasuda Luiz Sérgio Fonseca de Azevedo Hélio Helh Caiaffa-Filho Lígia Camera Pierrotti Maria Zilda de Aquino Marta Heloisa Lopes Natalya Zaidan Maluf Silvia Vidal Campos Silvia Figueiredo Costa |
author_sort |
Heloisa Helena de Sousa Marques |
title |
Management of post-transplant Epstein-Barr virus-related lymphoproliferative disease in solid organ and hematopoietic stem cell recipients |
title_short |
Management of post-transplant Epstein-Barr virus-related lymphoproliferative disease in solid organ and hematopoietic stem cell recipients |
title_full |
Management of post-transplant Epstein-Barr virus-related lymphoproliferative disease in solid organ and hematopoietic stem cell recipients |
title_fullStr |
Management of post-transplant Epstein-Barr virus-related lymphoproliferative disease in solid organ and hematopoietic stem cell recipients |
title_full_unstemmed |
Management of post-transplant Epstein-Barr virus-related lymphoproliferative disease in solid organ and hematopoietic stem cell recipients |
title_sort |
management of post-transplant epstein-barr virus-related lymphoproliferative disease in solid organ and hematopoietic stem cell recipients |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2014 |
url |
https://doi.org/10.1590/0037-8682-0036-2014 https://doaj.org/article/bd4f9547bcab44f3bb886a44f594018c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 47, Iss 5, Pp 543-546 (2014) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000500543&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0036-2014 https://doaj.org/article/bd4f9547bcab44f3bb886a44f594018c |
op_doi |
https://doi.org/10.1590/0037-8682-0036-2014 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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47 |
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543 |
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