Epilepsy surveillance in normocephalic children with and without prenatal Zika virus exposure.
Children with Congenital Zika Syndrome and microcephaly are at high risk for epilepsy; however, the risk is unclear in normocephalic children with prenatal Zika virus (ZIKV) exposure [Exposed Children (EC)]. In this prospective cohort study, we performed epilepsy screening in normocephalic EC alongs...
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Online Access: | https://doi.org/10.1371/journal.pntd.0008874 https://doaj.org/article/bd0a960094df4885b3d35bd3e5d4f1f5 |
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ftdoajarticles:oai:doaj.org/article:bd0a960094df4885b3d35bd3e5d4f1f5 2023-05-15T15:16:25+02:00 Epilepsy surveillance in normocephalic children with and without prenatal Zika virus exposure. Karen Blackmon Randall Waechter Barbara Landon Trevor Noël Calum Macpherson Tyhiesia Donald Nikita Cudjoe Roberta Evans Kemi S Burgen Piumi Jayatilake Vivian Oyegunle Otto Pedraza Samah Abdel Baki Thomas Thesen Dennis Dlugos Geetha Chari Archana A Patel Elysse N Grossi-Soyster Amy R Krystosik A Desiree LaBeaud 2020-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008874 https://doaj.org/article/bd0a960094df4885b3d35bd3e5d4f1f5 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008874 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008874 https://doaj.org/article/bd0a960094df4885b3d35bd3e5d4f1f5 PLoS Neglected Tropical Diseases, Vol 14, Iss 11, p e0008874 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008874 2022-12-31T10:07:26Z Children with Congenital Zika Syndrome and microcephaly are at high risk for epilepsy; however, the risk is unclear in normocephalic children with prenatal Zika virus (ZIKV) exposure [Exposed Children (EC)]. In this prospective cohort study, we performed epilepsy screening in normocephalic EC alongside a parallel group of normocephalic unexposed children [Unexposed Children (UC)]. We compared the incidence rate of epilepsy among EC and UC at one year of life to global incidence rates. Pregnant women were recruited from public health centers during the ZIKV outbreak in Grenada, West Indies and assessed for prior ZIKV infection using a plasmonic-gold platform that measures IgG antibodies in serum. Normocephalic children born to mothers with positive ZIKV results during pregnancy were classified as EC and those born to mothers with negative ZIKV results during and after pregnancy were classified as UC. Epilepsy screening procedures included a pediatric epilepsy screening questionnaire and video electroencephalography (vEEG). vEEG was collected using a multi-channel microEEG® system for a minimum of 20 minutes along with video recording of participant behavior time-locked to the EEG. vEEGs were interpreted independently by two pediatric epileptologists, who were blinded to ZIKV status, via telemedicine platform. Positive screening cases were referred to a local pediatrician for an epilepsy diagnostic evaluation. Epilepsy screens were positive in 2/71 EC (IR: 0.028; 95% CI: 0.003-0.098) and 0/71 UC. In both epilepsy-positive cases, questionnaire responses and interictal vEEGs were consistent with focal, rather than generalized, seizures. Both children met criteria for a clinical diagnosis of epilepsy and good seizure control was achieved with carbamazepine. Our results indicate that epilepsy rates are modestly elevated in EC. Given our small sample size, results should be considered preliminary. They support the use of epilepsy screening procedures in larger epidemiological studies of children with congenital ZIKV ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 11 e0008874 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Karen Blackmon Randall Waechter Barbara Landon Trevor Noël Calum Macpherson Tyhiesia Donald Nikita Cudjoe Roberta Evans Kemi S Burgen Piumi Jayatilake Vivian Oyegunle Otto Pedraza Samah Abdel Baki Thomas Thesen Dennis Dlugos Geetha Chari Archana A Patel Elysse N Grossi-Soyster Amy R Krystosik A Desiree LaBeaud Epilepsy surveillance in normocephalic children with and without prenatal Zika virus exposure. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Children with Congenital Zika Syndrome and microcephaly are at high risk for epilepsy; however, the risk is unclear in normocephalic children with prenatal Zika virus (ZIKV) exposure [Exposed Children (EC)]. In this prospective cohort study, we performed epilepsy screening in normocephalic EC alongside a parallel group of normocephalic unexposed children [Unexposed Children (UC)]. We compared the incidence rate of epilepsy among EC and UC at one year of life to global incidence rates. Pregnant women were recruited from public health centers during the ZIKV outbreak in Grenada, West Indies and assessed for prior ZIKV infection using a plasmonic-gold platform that measures IgG antibodies in serum. Normocephalic children born to mothers with positive ZIKV results during pregnancy were classified as EC and those born to mothers with negative ZIKV results during and after pregnancy were classified as UC. Epilepsy screening procedures included a pediatric epilepsy screening questionnaire and video electroencephalography (vEEG). vEEG was collected using a multi-channel microEEG® system for a minimum of 20 minutes along with video recording of participant behavior time-locked to the EEG. vEEGs were interpreted independently by two pediatric epileptologists, who were blinded to ZIKV status, via telemedicine platform. Positive screening cases were referred to a local pediatrician for an epilepsy diagnostic evaluation. Epilepsy screens were positive in 2/71 EC (IR: 0.028; 95% CI: 0.003-0.098) and 0/71 UC. In both epilepsy-positive cases, questionnaire responses and interictal vEEGs were consistent with focal, rather than generalized, seizures. Both children met criteria for a clinical diagnosis of epilepsy and good seizure control was achieved with carbamazepine. Our results indicate that epilepsy rates are modestly elevated in EC. Given our small sample size, results should be considered preliminary. They support the use of epilepsy screening procedures in larger epidemiological studies of children with congenital ZIKV ... |
format |
Article in Journal/Newspaper |
author |
Karen Blackmon Randall Waechter Barbara Landon Trevor Noël Calum Macpherson Tyhiesia Donald Nikita Cudjoe Roberta Evans Kemi S Burgen Piumi Jayatilake Vivian Oyegunle Otto Pedraza Samah Abdel Baki Thomas Thesen Dennis Dlugos Geetha Chari Archana A Patel Elysse N Grossi-Soyster Amy R Krystosik A Desiree LaBeaud |
author_facet |
Karen Blackmon Randall Waechter Barbara Landon Trevor Noël Calum Macpherson Tyhiesia Donald Nikita Cudjoe Roberta Evans Kemi S Burgen Piumi Jayatilake Vivian Oyegunle Otto Pedraza Samah Abdel Baki Thomas Thesen Dennis Dlugos Geetha Chari Archana A Patel Elysse N Grossi-Soyster Amy R Krystosik A Desiree LaBeaud |
author_sort |
Karen Blackmon |
title |
Epilepsy surveillance in normocephalic children with and without prenatal Zika virus exposure. |
title_short |
Epilepsy surveillance in normocephalic children with and without prenatal Zika virus exposure. |
title_full |
Epilepsy surveillance in normocephalic children with and without prenatal Zika virus exposure. |
title_fullStr |
Epilepsy surveillance in normocephalic children with and without prenatal Zika virus exposure. |
title_full_unstemmed |
Epilepsy surveillance in normocephalic children with and without prenatal Zika virus exposure. |
title_sort |
epilepsy surveillance in normocephalic children with and without prenatal zika virus exposure. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008874 https://doaj.org/article/bd0a960094df4885b3d35bd3e5d4f1f5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 11, p e0008874 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008874 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008874 https://doaj.org/article/bd0a960094df4885b3d35bd3e5d4f1f5 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008874 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
11 |
container_start_page |
e0008874 |
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1766346708713734144 |