Pulmonary involvement from animal toxins: the cellular mechanisms
Abstract Venomous animals and their venom have always been of human interest because, despite species differences, coevolution has made them capable of targeting key physiological components of our bodies. Respiratory failure from lung injury is one of the serious consequences of envenomation, and t...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
SciELO
2023
|
Subjects: | |
Online Access: | https://doi.org/10.1590/1678-9199-jvatitd-2023-0026 https://doaj.org/article/bc917c9af3fd4427aeecb060e90d4639 |
id |
ftdoajarticles:oai:doaj.org/article:bc917c9af3fd4427aeecb060e90d4639 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:bc917c9af3fd4427aeecb060e90d4639 2023-10-09T21:49:04+02:00 Pulmonary involvement from animal toxins: the cellular mechanisms Suthimon Thumtecho Suchai Suteparuk Visith Sitprija 2023-09-01T00:00:00Z https://doi.org/10.1590/1678-9199-jvatitd-2023-0026 https://doaj.org/article/bc917c9af3fd4427aeecb060e90d4639 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992023000100206&lng=en&tlng=en http://www.scielo.br/pdf/jvatitd/v29/1678-9199-jvatitd-29-e20230026.pdf https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2023-0026 https://doaj.org/article/bc917c9af3fd4427aeecb060e90d4639 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 29 (2023) lung injury animal toxin cellular mechanism pulmonary edema pulmonary hemorrhage Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2023 ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-2023-0026 2023-09-24T00:39:31Z Abstract Venomous animals and their venom have always been of human interest because, despite species differences, coevolution has made them capable of targeting key physiological components of our bodies. Respiratory failure from lung injury is one of the serious consequences of envenomation, and the underlying mechanisms are rarely discussed. This review aims to demonstrate how toxins affect the pulmonary system through various biological pathways. Herein, we propose the common underlying cellular mechanisms of toxin-induced lung injury: interference with normal cell function and integrity, disruption of normal vascular function, and provocation of excessive inflammation. Viperid snakebites are the leading cause of envenomation-induced lung injury, followed by other terrestrial venomous animals such as scorpions, spiders, and centipedes. Marine species, particularly jellyfish, can also inflict such injury. Common pulmonary manifestations include pulmonary edema, pulmonary hemorrhage, and exudative infiltration. Severe envenomation can result in acute respiratory distress syndrome. Pulmonary involvement suggests severe envenomation, thus recognizing these mechanisms and manifestations can aid physicians in providing appropriate treatment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 29 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
lung injury animal toxin cellular mechanism pulmonary edema pulmonary hemorrhage Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
lung injury animal toxin cellular mechanism pulmonary edema pulmonary hemorrhage Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Suthimon Thumtecho Suchai Suteparuk Visith Sitprija Pulmonary involvement from animal toxins: the cellular mechanisms |
topic_facet |
lung injury animal toxin cellular mechanism pulmonary edema pulmonary hemorrhage Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Venomous animals and their venom have always been of human interest because, despite species differences, coevolution has made them capable of targeting key physiological components of our bodies. Respiratory failure from lung injury is one of the serious consequences of envenomation, and the underlying mechanisms are rarely discussed. This review aims to demonstrate how toxins affect the pulmonary system through various biological pathways. Herein, we propose the common underlying cellular mechanisms of toxin-induced lung injury: interference with normal cell function and integrity, disruption of normal vascular function, and provocation of excessive inflammation. Viperid snakebites are the leading cause of envenomation-induced lung injury, followed by other terrestrial venomous animals such as scorpions, spiders, and centipedes. Marine species, particularly jellyfish, can also inflict such injury. Common pulmonary manifestations include pulmonary edema, pulmonary hemorrhage, and exudative infiltration. Severe envenomation can result in acute respiratory distress syndrome. Pulmonary involvement suggests severe envenomation, thus recognizing these mechanisms and manifestations can aid physicians in providing appropriate treatment. |
format |
Article in Journal/Newspaper |
author |
Suthimon Thumtecho Suchai Suteparuk Visith Sitprija |
author_facet |
Suthimon Thumtecho Suchai Suteparuk Visith Sitprija |
author_sort |
Suthimon Thumtecho |
title |
Pulmonary involvement from animal toxins: the cellular mechanisms |
title_short |
Pulmonary involvement from animal toxins: the cellular mechanisms |
title_full |
Pulmonary involvement from animal toxins: the cellular mechanisms |
title_fullStr |
Pulmonary involvement from animal toxins: the cellular mechanisms |
title_full_unstemmed |
Pulmonary involvement from animal toxins: the cellular mechanisms |
title_sort |
pulmonary involvement from animal toxins: the cellular mechanisms |
publisher |
SciELO |
publishDate |
2023 |
url |
https://doi.org/10.1590/1678-9199-jvatitd-2023-0026 https://doaj.org/article/bc917c9af3fd4427aeecb060e90d4639 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 29 (2023) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992023000100206&lng=en&tlng=en http://www.scielo.br/pdf/jvatitd/v29/1678-9199-jvatitd-29-e20230026.pdf https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2023-0026 https://doaj.org/article/bc917c9af3fd4427aeecb060e90d4639 |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-2023-0026 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
29 |
_version_ |
1779312097046298624 |